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个人简介：
肖樟平，博士，研究员，博士生导师，国家级青年人才和欧盟玛丽·居里学者等项目获得者。本科和硕士分别毕业于南昌大学和北京大学，2021年获得荷兰格罗宁根大学博士学位，并先后在英国伦敦帝国理工学院从事博士后研究和担任香港合成化学暨分子生物学实验室资深研究员，现为暨南大学生物活性分子与成药性优化全国重点实验室研究员。课题组主要致力于新型小分子药物研发及其在肿瘤、慢性呼吸性疾病等领域的应用研究。
主要研究方向：
1. 邻近诱导药物（如蛋白降解剂）的药物化学和化学生物学；
2. 基于化学蛋白质组学和DEL技术的共价药物研究；
3. 蛋白翻译后修饰（PTM）的调控；
4. 蛋白-蛋白相互作用抑制剂。
代表性论文：
(*第一作者，#通讯作者)
1. Gray, J.*, Xiao, Z.*, Rogga, V. V., Zhang, X., Tate, E. W.# From serendipity to strategy: rationalizing molecular gluediscovery and proximity-induced pharmacology through chemicalbiology. J. Am. Chem. Soc.2026, 148, 4791. (Perspective)
2. Xiao, Z.#, Gavriil, E. S., Cao, F., Zhang, X., Li, S. X., Kotelnikov, S., Michalska, P., Marte, F., Huang, C., Lu, Y. and Zhang, Y.,Bernardini, E., Kozakov, D., Tate, E. W.# Identification of actionable targeted protein degradation effector sites through Site-specific Ligand Incorporation-induced Proximity (SLIP). J. Am. Chem. Soc.2025,147, 21549.
3. Xiao, Z., Gray, J. L., Tate, E. W.# Weaponizing the proteasome to overcome antimalarial drug resistance. Cell Chem. Biol., 2023, 30, 415. (Preview)
4. Xiao, Z., Osipyan, A., Song, S., Chen, D., Schut R. A., van Merkerk, R, van der Wouden, P.E., Cool, R.H., Quax, W.J., Melgert, B.N. and Poelarends, G.J., Dekker, F. J.# A thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione derivative inhibits D-dopachrome tautomerase activity and suppresses proliferation of non-small cell lung cancer cells. J. Med. Chem.2022, 65, 2059.
5. Chen D.*, Xiao Z.*, Guo H., Gogishvili D., Setroikromo R., van der Wouden P. E., Dekker F. J.# Identification of a bromodomain-like region in 15-lipoxygenase-1 explains its nuclear localization. Angew. Chem. Int. Ed.2021. 60,21875.
6. Xiao, Z.*, Song, S.*, Chen, D., van Merkerk, R., van Der Wouden, P.E., Cool, R.H., Quax, W.J., Poelarends, G.J., Melgert, B.N., Dekker, F. J.# Proteolysis targeting chimera (PROTAC) for macrophage migration inhibitory factor (MIF) has anti-proliferative activity in lung cancer cells. Angew. Chem. Int. Ed.2021, 60, 17514.
7. Xiao, Z., Chen, D., Song, S., van der Vlag, R., van der Wouden, P. E., van Merkerk, R., Cool, R.H., Hirsch, A.K., Melgert, B.N., Quax, W.J. and Poelarends, G.J., Dekker, F. J.# 7-Hydroxycoumarins are affinity-based fluorescent probes for competitive binding studies of macrophage migration inhibitory factor. J. Med. Chem.2020, 63, 11920.
8. Xiao, Z., Fokkens, M., Chen, D., Kok, T., Proietti, G., van Merkerk, R., Poelarends, G.J. and Dekker, F.J. # Structure-activity relationships for binding of 4-substituted triazole-phenols to macrophage migration inhibitory factor (MIF). Eur. J. Med. Chem.2020, 186, 111849.
联系方式：
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