张有为，教授，博士生导师、硕士生导师，国家级领军人才。本科毕业于沈阳药科大学，获沈阳药科大学“药物化学”和原日本东京医科齿科大学“理学”双博士学位。曾于美国The Burnham Institute和The Salk Institute从事博士后研究；回国前任美国凯斯西储大学医学院药理系长聘正教授。2026年6月全职加入暨南大学药学院。

       研究方向聚焦于基因组稳定性维持机制及其在肿瘤发生发展与治疗中的应用，重点解析DNA损伤应答与修复、异染色质相分离调控及微环境应激调控等机制，揭示其在肿瘤演进中的作用。结合遗传学、结构生物学、人工智能与药理学，探索基因组稳定性网络中的新型治疗靶点及抗肿瘤干预策略。已发表SCI论文60余篇，其中中科院一区论文21篇，以第一作者或通讯作者身份发表于Molecular Cell、Nature Communications、Science Advances、PNAS、Cancer Research、Cell Reports、Journal of Medicinal Chemistry、Journal of Biological Chemistry、Oncogene等国际权威期刊。累计主持科研项目12项，总经费约5,250万元人民币。

       联系邮箱:  ywzhang1359@jnu.edu.cn或

       代表性文章(*通讯作者; #共一作者):

       1.Bei Zhang^#, Zhipeng Xu^#, Danmei Tian^#, Fangfang Wang^#, Min Zhao, Ping Hu, Youwei Zhang*, Zhang Zhang* and Jinshan Tang*.Design, synthesis, and antitumor evaluation of novel Shikonin derivatives: Discovery of 3k as a dual activator of the integrated stress response and ROS in gastric cancer. Journal of Medicinal Chemistry, 6c0009, 2026.

       2.Meng Yuan^#, Zhipeng Xu^#, Danmei Tian^#, Fangfang Wang^#, Zixuan Xia, Bei Zhang, Youwei Zhang*, Jinshan Tang*.Chemical proteomics identifies an autophagy receptor as a functional target of Shikonin in enhancing chemotherapy. Phytomedicine, 158310, 2026.

       3.Fangfang Wang, Bei Zhang, Fengge Yang, Bin Zhang, Jinshan Tangand Youwei Zhang*. Wild type HRAS mediates the DNA replication checkpoint. Genes & Diseases, 102155, 2026.

       4.Franklin Mayca Pozo, Xinran Geng, Masaru Miyagi, Amanda Amin, Alex Huang and Youwei Zhang*. MYO10 regulates genome stability and cancer inflammation through mediating mitosis.Cell Reports, 42, 112531, 2023.

       5.Fangfang Wang, Meng Zhang, Meng Yuan, Zixuan Xia, Fengge Yang, Sihao Zhang, Tengyu Lin, Lianxiang Luo, Jinshan Tangand Youwei Zhang*. A novel sorbicillinoid compound as a potent anti-inflammation agent through inducing NLRP3 protein degradation. British Journal of Pharmacology, 180, 1930-1948, 2023.

       6.Fangfang Wang, Sora Jin, Franklin Mayca Pozo, Danmei Tian, Xiyang Tang, Yi Dai, Xinsheng Yao, Jinshan Tangand Youwei Zhang*. Chemical screen identifies Shikonin as a broad DNA damage response inhibitor that sensitizes chemotherapy through inhibiting ATM and ATR. Acta Pharmaceutica Sinica B, 12, 1339-1350, 2022.

       7.Lei Zhang^#, Xinran Geng^#, Fangfang Wang^#, Jinshan Tang, Yu Ichida, Sharma Arishya, Sora Jin, Minyue Chen, Mingliang Tang, Franklin Mayca Pozo, Wenxiu Wang, Janet Wang, Michal Wozniak, Xiaoxia Guo, Masaru Miyagi, Fulai Jin, Yongjie Xu, Xinsheng Yao and Youwei Zhang*. 53BP1 regulates heterochromatin through liquid phase separation.Nature Communications, 13, 360, 2022.

       8.Franklin Mayca Pozo, Xinran Geng, Ilaria Tamagno, Mark Jackson, Ernest G. Heimsath, John Hammer, Richard Cheney and Youwei Zhang*. MYO10 drives genomic instability and inflammation in cancer.Science Advances, 7, eabg6908, 2021.

       9.Danmei Tian^#,Jinshan Tang^#, Xinran Geng^#, Qingwen Li, Fangfang Wang, Huadong Zhao, Goutham Narla, Xinsheng Yao and Youwei Zhang*. Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy.Cancer Letters, 493, 80-90, 2020.

       10.Yifang Li, Shuhua Ouyang, Longfang Tu, Xi Wang, Weilin Yuan, Guoen Wang, Yanping Wu, Wenjun Duan, Hongmin Yu, Zhongze Fang, Hiroshi Kurihara, Youwei Zhang* and Rongrong He*. Caffeine protects skin from oxidative stress-induced senescence through the activation of autophagy. Theranostics, 8, 5713-5730, 2018.

       11.Xiangzi Han, Jinshan Tang, Jingna Wang, Jinhua Zheng, Feng Ren, Megan Gragg, Philip Kiser, Paul Park, Krzysztof Palczewski, Xinsheng Yao and Youwei Zhang*. Conformational change of human checkpoint kinase 1 (Chk1) induced by DNA damage. Journal of Biological Chemistry,291, 12951-12959, 2016.

       12.Xiangzi Han^#, Lei Zhang^#, Jin Sil Chung^#, Franklin Mayca Pozo, Amada Tran, Darcie Searchist, James Jacobberger, Ruth Keri, Hannah Gilmore and Youwei Zhang*. UbcH7 regulates 53BP1 stability and DSB repair. Proceedings of the National Academy of Sciences, 111, 17456-61, 2014.

       13.Jingna Wang^#, Xiangzi Han^#, Xiujin Feng, Zhenghe Wang and Youwei Zhang*. Coupling cellular localization and function of Chk1 in checkpoints and cell viability. Journal of Biological Chemistry, 287, 25501-25509, 2012.

       14.Jingna Wang^#, Xiangzi Han^#, and Youwei Zhang*. Autoregulatory mechanisms of phosphorylation of checkpoint kinase 1. Cancer Research, 72, 3786-3794, 2012.

       15.Youwei Zhang*, John Brognard, Chris Coughlin, Zhongshen You, Marisa Dolled-Filhard, Aaron Aslanian, Gerard Manning, Robert T.  Abraham, and Tony Hunter. The F-box protein Fbx6 regulate Chk1 stability and cellular sensitivity to replication stress.  Molecular Cell, 35, 442-453, 2009.

       16.Youwei Zhang, Dianne M. Otterness, Gary G. Chiang, Yuncai Liu, Weilin Xie, Frank Mercurio, and Robert T. Abraham. Genotoxic Stress Targets Human Chk1 for Degradation by the Ubiquitin-Proteasome Pathway.  Molecular Cell, 19, 607-618, 2005.

       17.Youwei Zhang*, Makoto Kaneda, and Ikuo Morita. The gap junction-independent tumor suppressing effect of connexin 43.  Journal of Biological Chemistry, 278, 44852-44856, 2003.

       18.Youwei Zhang*, Keiko Nakayama, Kei-Ichi Nakayama, and Ikuo Morita. A Novel Route for Connexin 43 to Inhibit Cell Proliferation: Negative Regulation of S-phase kinase-associated protein (Skp2).  Cancer Research, 63, 1623-1630, 2003.

       19.Youwei Zhang, Ikuo Morita, Masa-aki Ikeda, Kai-Wen Ma, and Sei-itsu Murota. Connexin 43 suppresses proliferation of osteosarcoma U2OS cells through posttranscriptional regulation of p27.  Oncogene, 20: 4138-4149, 2001.