1、个人简介

  张冬梅，女，博士，研究员，博士生导师。暨南大学药学院院长、基因工程药物国家工程中心副主任。国家高层次人才计划领军人才和青年拔尖人才、教育部新世纪优秀人才、广东省青年ZJ学者、广东省自然科学基金杰出青年科学基金获得者。担任广东省药理学会副理事长、中国药理学会理事、广东省女科技工作者联合会常务理事等。

   从事肿瘤药理学研究和新药研发。先后主持国家重大新药创制专项课题（2项）、国家自然科学基金联合基金重点项目、广东省自然科学基金重点项目等国家和省部级项目17项。以通讯作者在Gut、Nat Metabolism、J Clin Invest、Drug Res Updat、Nat Commun、Adv Sci等权威杂志发表SCI论文60余篇。获授权国际发明专利13项，中国发明专利12项，其中7项专利已转化。获国家科学技术进步奖二等奖1项、广东省科学技术奖一等奖3项、广东省丁颖科技奖、广东省三八红旗手标兵、广东省南粤优秀教育工作者等称号。

2、研究方向：

  （1）肿瘤转移和耐药的新机制和新靶标发现

  （2）抗肿瘤新药发现和转化研究

3、代表性论文：

1. Wang S, Ye GN, Xu XL, Lin YN, Li XB, Zhang Z, Qi M, Tan L, Cheng MJ, Zhang HS, Pan JH, Lin CW, Huang DD, Deng R, Li XM, Wang GS, Qiu SH, Chu XD, Chen YH, Zeng HH, Zhang JQ, Wang CR, Shuai HL, Shi CZ, Yuan X, Cao YH*, Chen MF*, Huang MH*, Ye WC*, Zhang DM*. Pericyte drives the formation of circulating tumor cell-neutrophil clusters to promote colorectal cancer metastasis. Gut, 2025, 75(1): 81-93.

2. Li XB, Pan JH, Liu TZ, Yin WQ, Miao Q, Zhao Z, Gao YF, Zheng W, Li H, Deng R, Huang DD, Qiu SH, Zhang YR, Qi Q, Deng LJ, Huang MH, Tang PMK, Cao YH, Chen MF*, Ye WC*, Zhang DM*. Novel TCF21highpericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix. Gut, 2023, 72(4): 710–721.

3. Wang CR, Huang MH, Lin YN, Zhang YM, Pan JH, Jiang C, Cheng MJ, Li SR, He WZ, Li ZQ, Tu ZC, Fan J, Zeng HH, Lin JH, Wang YJ, Yao N, Liu TZ, Qi Q, Liu XN, Zhang ZM, Chen MF*, Xia LP*, Zhang DM*, Ye WC*. ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy. Nature Metabolism, 2023, 5(10): 1765–1786.

4. Qi M, Fan SR, Huang MH, Pan JH, Li Y, Miao Q, Lyu WY, Li XB, Deng LJ, Qiu SH, Liu TZ, Deng WQ, Chu XD, Jiang C, He WZ, Xia LP, Yang YL, Hong J, Qi Q, Yin WQ, Liu XN, Shi CZ, Chen MF*, Ye WC*, Zhang DM*. Targeting FAPα-expressing hepatic stellate cells overcomes resistance to anti-angiogenics in colorectal cancer liver metastasis models. The Journal of Clinical Investigation, 2022, 132(19): e157399.

5. Li XB, Qi Q, Li Y, Miao Q, Yin WQ, Pan JH, Zhao Z, Chen XY, Yang F, Zhou XF, Huang MH, Wang CR, Deng LJ, Huang DD, Qi M, Fan SR, Zhang YR, Qiu SH, Deng WQ, Liu TZ, Chen MF*, Ye WC*, Zhang DM*. TCAF2 in pericytes promotes colorectal cancer liver metastasis via inhibiting cold-sensing TRPM8 channel. Advanced Science, 2023, 10(30):e2302717.

6. Li XB, Yan SS, Xiaoyu Wu, Miao Q, Zhang D, Mai WF, Han S, Tang ZS, Ye MF, Zhang S, Wei JA, Pan JH, Huang DD, Qiu SH, Zhao Z, Zhong XT, Huang MH, Qi M, Zhang JQ, Wang CR, Xie JW, Wang S, Oscar Luo JH*, Zhang DM*, Ye WC*, Chen MF*. Pericytes promote metastasis by regulating tumor local vascular tone and hemodynamics. Nat Commun, 2025,16:7115.

7. Wang S, Ye GN, Zhang CY, Tan L, Zhang Z, Xu X, Chen XH, Zhang YM, Xu XL, Pan JH, Lan T, Zhang JQ, Lin CW, Huang DD, Li XB, Yuan X, Chen MF, Wang CR*, Ye WC*, Zhang DM*, Huang MH*. Pericyte NNMT drives an immune-hostile vascular niche and restricts cancer immunotherapy. Science bulletin, 2026,71(8):1912-1916.

8. Wen Q, Huang MH, Xie JW, Liu RY, Miao Q, Huang JJ, Zhang JQ, lyu WY, Qi M, Wu CY, Qi Q, Zhang ZJ, Deng R, Wang CR, Chen ZS, Zhang DM*, Ye WC*, Chen MF*. lncRNA SYTL5-OT4 promotes vessel co-option by inhibiting the autophagic degradation of ASCT2. Drug Resistance Updates, 2023, 69: 100975.

9. Huang MH, Lin YN, Wang CR, Deng LJ, Chen MF, Assaraf YG, Chen ZS*, Ye WC*, Zhang DM*. New insights into antiangiogenic therapy resistance in cancer: mechanisms and therapeutic aspects. Drug Resistance Updates, 2022, 64: 100849.

10. Yin WQ, Yao HQ, Li XB, Pan WX, Zhang YK, Wang CR, Deng LJ, Lin CW, Zhang ZM, Pan JH, Han SH, Tang ZH, Zhao Z, Zhu CJ, Li ST, Huang MH, Chen MF, Xue Y, Zhang JQ*, Ye WC*, Zhang DM*. Targeting TCF21-TCF3 heterodimer in tumor-associated pericytes attenuates hematogenous metastasis by restoring pericyte gatekeeper function. Cell Reports Medicine, 2026, 7(1):102569.

4、联系方式：

联系邮箱：dmzhang701@jnu.edu.cn