张兴旺，副教授，硕士生导师。复旦大学博士，上海市研究生优秀学位论文（博士）成果奖获得者，暨南大学优秀青年教师。现任Chinese Chemical Letters编委、中国纳米生物技术专业委员会委员、中国医药教育协会皮肤药学专业委员会委员、世中联中药制剂专业委员会理事，Acta Pharm Sin B、Chinese Chem Lett、Int J Pharm、药学学报、药学前沿等数十种国内外期刊同行评议人。近五年主讲各层次《药剂学》(英文)、《生物药剂学与药动学》(英文)、《中药药剂学》、《新制剂研发全流程设计与应用》等课程。学术成果入选2025年度全球前2%顶尖科学家“年度科学影响力排行榜”。

主要研究方向为纳米递药系统、药物传递新技术、中西药物制剂研究与开发。先后主持国家自然科学基金、广东省自然科学基金等项目多项。在Acta Pharm Sin B、Chin Chem Lett、Biomater Res、Drug Discov Today、Mol Pharmceut、Eur J Pharm Biopharm、Int J Nanomedicine等学术期刊发表SCI论文70余篇，在中药活性成分递送及纳米制剂体内外评价方面开展了系列前瞻性研究。参编《中药药剂学》《分子生物药剂学》《新型药物制剂学》（化学工业出版社）教材3部。

主要研究方向

       1.   纳米递药系统

       2.  中药活性成分递送与评价

       3.  中西药物制剂开发与评价

代表性论文

       1. Liang Yan, Qi Feng, Yong Sun, Boning Zeng, Chuanchuan Sun, Qingbing Zha*, Xingwang Zhang*, and Shiping Zhu*. Selenized Tripterine Phytosomes Alleviate Ferroptosis-Mediated Acute Kidney Injury by Suppressing GPX4 Degradation via the DUSP1/Autophagy Pathway. Biomater Res. 2025; 29: 0236.

    2. Huijie Xing, Guichan Li, Chunli Qi, Ming Zhang, Ning Ding, Xingwang Zhang*. Emerging Role of Plant-Derived Nanostructures in Nanomedicine. Int J Nanomedicine. 2025; 20:12715-12731.

      3. Fengjie Liu, Fansu Meng, Zhenjiang Yang, Huan Wang, Yuehong Ren, Yu Ca*, Xingwang Zhang*. Exosome-biomimetic nanocarriers for oral drug delivery. Chin Chem Lett. 2024; 35(9):109335.

      4. Yuehong Ren, Wei Wu, Xingwang Zhang*. The feasibility of oral targeted drug delivery: Gut immune to particulates? Acta Pharm Sin B. 2023; 13(6): 2544-2558.

       5. Mujuan Zhu, Shiping Zhu, Qiubo Liu, Yuehong Ren, Zhiguo Ma*, Xingwang Zhang*. Selenized liposomes with ameliorative stability that achieve sustained release of emodin but fail in bioavailability. Chin Chem Lett. 2023; 34(1):107482.

    6. Shiping Zhu, Chunhua Luo, Weifeng Feng, Yan Li, Mujuan Zhu, Shengyun Sun*, Xingwang Zhang*. Selenium-deposited tripterine phytosomes ameliorate the antiarthritic efficacy of the phytomedicine via a synergistic sensitization. Int J Pharm. 2020; 578: 119104.

       7. Qian Xie, Wenji Deng, Xue Yuan, Huan Wang, Zhiguo Ma, Baojian Wu, Xingwang Zhang*. Selenium-functionalized liposomes for systemic delivery of doxorubicin with enhanced pharmacokinetics and anticancer effect. Eur J Pharm Biopharm. 2018; 122: 87-95.

       8. Wenji Deng, Qian Xie, Huan Wang, Zhiguo Ma, Boajian Wu*, Xingwang Zhang*. Selenium nanoparticles as versatile carriers for oral delivery of insulin: insight into the synergic antidiabetic effect and mechanism. Nanomedicine. 2017; 13: 1965-1974.

       9. Xingwang Zhang, Dong Dong, Huailing Wang, Zhiguo Ma, Baojian Wu*. Stable knockdown of efflux transporters leads to reduced glucuronidation in UGT1A1-overexpressing HeLa cells: the evidence for glucuronidation-transport interplay. Mol Pharm. 2015; 12(4): 1268-78.

       10. Xingwang Zhang, Tianpeng Zhang, Yanghuan Ye, Huaqing Chen, Hua Sun, Xiaotong Zhou, Zhiguo Ma, Baojian Wu*. Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect. Eur J Pharm Biopharma. 2015; 94:30-41.

联系方式

       地址：广州市番禺区兴业大道东855号暨南大学药学院741

       E-mail：zhangxw@jnu.edu.cn