刘畅，副研究员，博士生导师，暨南大学药学院院长助理。2019年博士毕业于暨南大学，同年进入暨南大学中西医结合博士后流动站，2021年进入暨南大学药学院工作。从事肿瘤药理学研究，围绕“肿瘤干细胞干性调控机制和药物干预”这一关键科学问题开展研究，以第一/通讯作者身份发表SCI论文十余篇，包括Cell Metab (2022), Cancer Res 2 篇 (2025，2018）, Adv Sci (2025)，Angew Chem Int Ed Engl (2025), Oncogene 2篇 (2025, 2021)等专业期刊。主持国家自然科学基金面上项目、青年科学基金项目、中国博士后科学基金面上项目以及省部级以上项目6项。

学术兼职

        1、担任中国抗癌协会抗癌药物专业委员会委员、中国老年学和老年医学学会老年病学分会肿瘤基础与转化研究专委会委员；

        2、担任APSB、Molecular Cancer、Experimental Hematology & Oncology及Star Protocols等SCI期刊杂志审稿人；

        3、The innovation oncology杂志青年编委。

代表性SCI论文

   1. Chang Liu, Danian Nie, Shuyi Li, Chen Duan, Min Zhou, Peilong Lai, Shengyong Yang, Sen Ji, Waiyi Zou, Yangqiu Li, Mei Mei, Shilai Bao, Yanli Jin*, Jingxuan Pan*. Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML [J]. Cell Metabolism. 2022; S1550-4131(22).

   2. Zhou M, Wu Z, Wei F, Duan C, Lin X, Zou W*, Liu C*, Pan J*, Jin Y*. SMYD3 Activates Fatty Acid β-Oxidation to Promote Self-Renewal of Leukemia Stem Cells. Cancer Res. 2025 Jun 2;85(11): 2027-2045.

   3. Zhou M, Huang Y, Xu P, Li S, Duan C, Lin X, Bao S*, Zou W*, Pan J*, Liu C*, Jin Y*. PRMT1 Promotes the Self-renewal of Leukemia Stem Cells by Regulating Protein Synthesis. Adv Sci (Weinh). 2025 Feb;12(5): e2308586.

   4. Lin SL, Zhao F, Wei F, Shi YT, Wen JK, Yang C, Zhang HS, Li CC, Liu C*, Ye WC*, Cheng MJ*, Wang L*. Visible-Light Photocatalyzed Skeletal Rearrangement Enables the Synthesis of Highly Functionalized Xanthenes with Antitumor Activity. Angew Chem Int Ed Engl. 2025 Feb 24;64(9): e202420671.

   5. Chen Duan, Xiaoying Lin, Waiyi Zou, Qi He, Fen Wei, Jingxuan Pan*, Chang Liu*and Yanli Jin*. Targeting DDX3X eliminates leukemia stem cells in chronicmyeloid leukemia by blocking NT5DC2 mRNA translation [J].Oncogene. 2024.

   6. Chang Liu; Xiaoying Lin; Yanli Jin; Jingxuan Pan; Protocol for isolation and analysis of the leukemia stem cells in BCR-ABL-driven chronic myelogenous leukemia mice, STAR Protocols, 2023, 4(1): 102123

   7. Chang Liu, Danian Nie, Juan Li, Xin Du, Yuhong Lu, Yangqiu Li, Jingfeng Zhou, Yanli Jin*, Jingxuan Pan*. Antitumor effects of blocking protein neddylation in T315I-BCR-ABL leukemia cells and leukemia stem cells [J]. Cancer Research, 2018;78(6),1522-1536.

   8. Min Zhou*, Xiuli Zhang *, Chang Liu*(共同第一), Danian Nie*, Shuyi Li, Peilong Lai, Yanli Jin. Targeting protein lysine methyltransferase G9A impairs self-renewal of chronic myelogenous leukemia stem cells via upregulation of SOX6 [J]. Oncogene. 2021;40(20):3564-3577.

   9. Zhou, Jingfeng; Nie, Danian; Li, Juan; Du, Xin; Lu, Yuhong; Li, Yangqiu; Liu, Chang; Dai, Wei; Wang, Yun; Jin, Yanli; Pan, Jingxuan; PTEN Is Fundamental for Elimination of Leukemia Stem Cells Mediated by GSK126 Targeting EZH2 in Chronic Myelogenous Leukemia, Clinical Cancer Research, 2018, 24(1): 145-157

   10. Jin Y, Nie D, Li J, Du X, Lu Y, Li Y, Liu C, Zhou J, Pan J*. Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing β-Catenin. Clin Cancer Res. 2017 Jun 1;23(11):2842-2855.

主持的科研项目

   1. 国家自然科学基金面上项目，2025-01至2028-12，主持；

   2. 国家自然科学基金青年基金， 2021-01至2022-12，主持；

   3. 中国博士后科学基金面上资助，2021-01至2022-12，主持；

   4. 广州市市校联合资助项目，2024-04至2026-03，主持；

   5. 广州市科技计划项目-青年博士启航项目，2024-04至2026-03，主持。

联系方式

        地址：广州市番禺区兴业大道东855号暨南大学药学院F2栋319