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李怡芳，暨南大学药学院教授、博士生导师，广东省疾病易感性及中医药研发工程技术研究中心副主任。
入选国家教育部重大人才计划特聘教授、广东省自然科学基金杰出青年、广州市珠江科技新星等人才项目。主要从事脂质氧化代谢调节疾病易感机制研究、免疫炎症药理学、中药抗感染研究。获科技部重点研发计划课题、国家自然科学基金、广东省自然科学基金等课题资助，获得广东省科技进步一等奖、教育部高等学校科技进步二等奖、中国专利优秀奖、中华中医药学会科学技术奖二等奖、树兰医学青年奖、中华中医药学会中青年创新人才奖。
主要研究方向：
1．药理学（免疫炎症调控机制、病毒易感机制、中药抗感染）
教育和工作经历：
2003/09–2007/07：江西中医药大学，药学院，药学/学士
2007/09–2010/06：暨南大学，药学院，药理学/硕士
2010/09–2013/06：暨南大学，药学院，生物医药工程/博士
2015/10–2020/09：暨南大学，药学院，副教授
2020/10– 至今：暨南大学，药学院，教授
主要学术奖励：
1) 树兰医学青年奖
2) 中华中医药学会中青年创新人才奖
3) 中华中医药学会科学技术奖二等奖（第1完成人）
4) 广东省科技进步一等奖（2018，第2完成人）
5) 广东省科技进步一等奖（2019，第2完成人）
6) 教育部科学技术进步二等奖（第2完成人）
7) 中国专利优秀奖（第3完成人）
人才计划：
1）教育部重大人才计划特聘教授
2）教育部重大人才计划青年学者
3）广东省自然科学卓越青年团队
4）广东省特支计划青年拔尖人才
5）广东省自然科学杰出青年
1. Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis. Nat Commun. 2025, 17, 16(1): 758.
2. Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis. Cell Rep. 2024, 27, 43(8): 114636.
3. Phospholipid peroxidation in macrophage confers tumor resistance by suppressing phagocytic capability towards ferroptotic cells. Cell Death Differ .2024, 31(9): 1184-1201.
4. Lipid peroxidation inhibition by icaritin and its glycosides as a strategy to combat iron overload-induced osteoporosis in zebrafish. Food Res Int .2025, 203:115900.
5. Prenatal hormone stress triggers embryonic cardiac hypertrophy outcome by ubiquitin-dependent degradation of mitochondrial mitofusin 2. iScience .2023, 27(1): 108690.
6. ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis. Pharmacol Res. 2023, 93: 106779.
7. An endogenous neuropeptide hormone assistscancer cells in escaping from immune surveillance. Sci China Life Sci .2023, 66(6): 1451-1453.
8. Tripeptide Leu-Pro-Phe from Corn Protein Hydrolysates Attenuates Hyperglycemia-Induced Neural Tube Defect in Chicken Embryos. Oxid Med Cell Longev. 2022, 29: 4932304.
9. ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage. Signal Transdu Target Ther. 2022, 7: 288.
10. An endogenous neuropeptide hormone assists cancer cells in escaping from immune surveillance. Life Sciences.2023,66(6):1451-1453.
11. Reducing lipid peroxidation attenuates stress-induced susceptibility to herpes simplex virus type 1. Acta Pharmacol Sin. 2023, 44(9):1856-1866.
12. Phospholipid peroxidation-dri ven modification of chondrogenic transcription factor mediates alkoxyl radicals-induced impairment of embryonic bone development. Redox Biol. 2022, 5 6:102437.
13. GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS. J Adv Res. 2022.
14. Theacrine, a Potent Antidepressant Purine Alkaloid from a Special Chinese Tea, Promotes Adult Hippocampal Neurogenesis in Stressed Mice. J Agric Food Chem. 2021, 69, 7016-7027.
15. Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS. Signal Transdu Target Ther. 2020, 5, Article number: 202.
16. Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. Cell Death Differ. 2021, 28: 1971-1989.
17. Identification and characterization of N9- methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nat Commun. 2020, 11:1473.
18. Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage. Redox Biol. 2018.14:1-6.
19. Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone. Theranostics.2020, 10(20): 9032-9049.
20. Caffeine protects skin from oxidative stress-induced senescence through the activation of autophagy. Theranostics .2018, 8(20):5713-5730.
21. Inhibitory effects of baicalein against herpes simplex virus type 1. Acta Pharm Sina B. 2020, 10(12): 2323-2338.
22. The disbalance of LRP1 and SIRPa by psychological stress dampens the clearance of tumor cells by macrophages. Acta Pharm Sin B .2022,12(1):197-209.
23. (+)-Clausenamide protects against drug-induced liver injury by inhibiting hepatocyte ferroptosis. Cell Death Dis. 2020: 11:781.
24. Disturbed YineYang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1. Acta Pharm Sina B. 2019, 10(3):383-398.
25. Celastrol ameliorates Propionibacterium acnes/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3. Phytomedicine. 2021, 80:153398.
26. Theacrine, a purine alkaloid from kucha, protects against Parkinson's disease through SIRT3 activation. Phytomedicine .2020, 77: 153281.
27. New insights into the effects and mechanism of a classic traditional Chinese medicinal formula on influenza prevention. Phytomedicine. 2017, 27:52-62.
28. Fostering efficacy and toxicity evaluation of traditional Chinese medicine and natural products: Chick embryo as a high throughput model bridging in vitro and in vivo studies. Pharmacol Res.2018 133:21-34.
29. Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson’s disease. Acta Pharmacol Sin. 2020, 0:1-11.
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