唐维，博士、硕士生导师。2015年6月毕业于暨南大学药物化学专业，获硕士学位。2017年3月-2019年3月获国家留学基金委公派资助，赴加州大学伯克利分校进行博士联合培养学习。2019年6月毕业于暨南大学中药化学专业，获医学博士学位，同年进入暨南大学中西医结合博士后科研流动站完成博士后研究工作。2022年入职暨南大学药学院，主要从事抗病毒药物及宿主与病毒互作机制研究，主持国家自然科学基金青年基金、广东省自然科学基金面上项目、中国博士后基金、广州市基础研究计划项目各1项，入选暨南大学青年科技人才托举工程项目，作为项目核心成员或骨干参与国家自然科学基金重大项目、广东省自然科学基金-卓越青年团队项目、广东省重点领域研发计划等项目7项。目前已发表研究论文38篇，其中SCI论文34篇，包括以第一作者(含共一)或通讯作者(含共通讯)在mBio、Acta Pharmaceutica Sinica B、Journal of Virology、Antiviral Research、Organic Chemistry Frontiers等本研究领域专业期刊发表论文13篇；申请中国发明专利11项，获授权8项，申请PCT国际专利2项。

近五年发表的论文：

1. Song Q Y#, Zhu H Y#, Qiu M L#, Cai J L#, Hu Y, Yang H X, Rao S W, Li Y L, Li M M, Hu L J, Wang S Q, Hong J, Ye W C*, Chen H R*, Wang Y*, Tang W*. A new mechanism of respiratory syncytial virus entry inhibition by small-molecule to overcome K394R-associated resistance. mBio, 2024: e01385─24.

2. Song J G#, Huang R L#, Cai J L, Wu Z L, Hu L J, Sun W Y, Huang X J, He R R, Tang W*, Ye W C*, Wang Y*. Targeted isolation of antiviral cinnamoylphloroglucinol-terpene adducts from Cleistocalyx operculatus by building blocks-based molecular networking approach. Acta Pharmaceutica Sinica B, 2024, 14(10): 4443─4460.

3. Zhang X L#, Xia Y P#, Li P B, Wu Z N, Li R L, Cai J L, Zhang Y B, Wang G C, Li Y L, Tang W*, Su W W*. Discovery of cyperenoic acid as a potent and novel entry inhibitor of influenza A virus. Antiviral Research. 2024, 223: 105822.

4. Tang W#, Li Y Y#, Song Q Y, Wang Z Q, Li M M, Zhang Q W, Wang Y*, Ye W C*, Li Y L*. Mechanism of cross-resistance to fusion inhibitors conferred by the K394R mutation in respiratory syncytial virus fusion protein. Journal of Virology, 2021, 95(20): 01205─21.

5. Liu F#, Gu J H#, Zhang Z Y, Zhan Q, Yang H X, Hu Y, Zhang J Y, Tang W*, Ye W C*, Wang L*. Xanthrysols A− D, Novel Meroterpenoids with Antiviral Activities from Xanthostemon chrysanthus. Organic Chemistry Frontiers, 2024, 11, 3814─3820

6. He J#, Huang H#, Li B, Li H, Zhao Y, Li Y, Ye W, Qi W, Tang W*, Wang L*. Identification of cytochrome c oxidase subunit 4 isoform 1 as a positive regulator of influenza virus replication. Frontiers in Microbiology, 2022, 13: 862205.

7. Tang W#, Li M M#, Liu Y J, Liang N, Yang Z, Zhao Y X, Wu S, Lu S W, Li Y L*, Liu F Y*. Small molecule inhibits respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane. FASEB Journal, 2019, 33(3): 4287─4299.

8. Huang, R L^#; Tang, W^#; Wang, C Q; Yan, C; Hu, Y; Yang, H X; Huang, X J; Hu, L J; Ye, W C*; Song, J G*; Wang, Y*. Antiviral C-geranylated flavonoids from Artocarpus communis. Phytochemistry, 2024, 225: 114165.

9. Wang J#, Song J G#, Zhong D L, Duan Z J, Peng Z J, Tang W, Song Q Y, Huang X J, Hu L J#, Wang Y*, Ye W C*. Biomimetic Synthesis of an Antiviral Cinnamoylphloroglucinol Collection from Cleistocalyx operculatus: A Synthesis Strategy Based on Biogenetic Building Blocks. Angewandte Chemie International Edition, 2023: e202312568.

10. Deng L M#, Hu L J#, Tang W#, Liu J, Huang X J, Li Y L, Li Y Y, Ye W C*, Wang Y*. A Biomimetic synthesis-enabled stereochemical assignment of rhodotomentones A and B, two unusual caryophyllene-derived meroterpenoids from Rhodomyrtus tomentosa. Organic Chemistry Frontiers, 2021, 8(20): 5728─5735.

11. Deng L M#, Tang W#, Wang S Q, Song J G, Huang X J, Zhu H Y, Li Y L, Ye W C*, Hu L J*, Wang Y*. Discovery and Biomimetic Synthesis of a Polycyclic Polymethylated Phloroglucinol Collection from Rhodomytus tomentosa. Journal of Organic Chemistry. 2022. 87(7): 4788─4800.

12. Li X Y#, Jiang J#, Shu B Y, Huang R L, Yang H X, Chen Y L, Tang W, Ye W C, Wang Y*, Huang X J*, Song J G*. Anti-inflammatory naphthoquinone-monoterpene adducts and neolignans from Eugenia caryophyllata. Fitoterapia, 2024: 105982.

13. Lin F L, Gao J L, Xu Q, Wang G Q*, Xiao L Y, Dong L, Tang W, Lv J M, Chen G D, Wang Y, Yin Z N, Lu L G, Hu D*, Gao H*. Absolute Configuration of Oxabornyl Polyenes Prugosenes A1-A3 and Structural Revision of Prugosene A2. Journal of Natural Products, 2024, 87(5): 1338–1346

14. Song J G#, Liu J X#, Huang R L, Tang W, Huang X J, Wang Y*, Ye W C*. Tautomeric cinnamoylphloroglucinol-monoterpene adducts from Cleistocalyx operculatus and their antiviral activities. Journal of Asian Natural Products Research. 2024, 26: 38–51.

15. Chen L F, Xu W B, Li Y Y, Chen N H, Luo D, Song Q Y, Tang W, Huang Z G, Li Y L*, Liu Z*, Li M M*. Inhibitory effect of PIK-24 on respiratory syncytial virus entry by blocking phosphatidylinositol-3 kinase signaling. Antimicrobial Agents and Chemotherapy, 2020, 64(10): 00608-20

16. Yang W Q#, Tang W#, Huang X J, Song J G, Li Y Y, Xiong Y, Fan C L, Wu Z L*, Wang Y*, Ye W C. Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities. Molecules.2021, 26(19): 5939.

17. Tan L X#, Xia T Q#, He Q F, Tang W, Huang X J, Song Q Y, Li Y L, Ye W C, Wang Y*, Wu Z L*. Stilbenes from the leaves of Cajanus cajan and their in vitro anti-inflammatory activities. Fitoterapia, 2022, 160: 105229.

18. Peng Y S#, Liu J X#, Jiao J, Qiu M L, Tang W, Song J G, Ye W C, Wang Y*, Huang X J*. Secoiridoid glycosides from the fruits of Ligustrum lucidum and their in vitro anti-inflammatory activity. Fitoterapia, 2023, 171: 105705.

19. Sheng B B#, Zeng C C#, Chen J, Ye W C, Tang W, Lan P*, Banwell M G*. Total Syntheses of the Imidazo [1, 2‐f] phenanthridine‐Containing Alkaloid Zephycandidine A. European Journal of Organic Chemistry, 2022, 2022(9): e202101511.

20. Ding X M, Ye W X, Tan B, Song Q Y, Chen Y C, Liu W, Sun LL, Tang W, Qiao Y L, Zhang Q B, Zhang H B, Wang Y, Zhang W M, Zhang C S*, Zhang W J*. Talachalasins A—C, Undescribed Cytochalasans with a 16 β‐Methyl or 2‐Oxabicyclo [3.3. 1] nonan‐3‐one unit from the Deep‐Sea‐Derived Fungus Talaromyces muroii sp. SCSIO 40439. Chinese Journal of Chemistry, 2023, 41(8): 915-923.

21. Song J G#, Tang W#, Wang X, Su J C, Huang X J, Shi L, Ye W C*, Wang Y*. Phloroglucinol-derived lipids from the leaves of syzygium cumini and their neuroprotective activities. Fitoterapia, 2021, 153: 104968.

22. Deng L M, Hu L J, Bai Y T, Wang J, Qin G Q, Song Q Y, Su J C, Huang X J, Jiang R W, Tang W, Li C C*, Ye W C*, Wang Y*. Rhodomentosones a and b: Two pairs of enantiomeric phloroglucinol trimers from rhodomyrtus tomentosa and their asymmetric biomimetic synthesis. Organic Letters, 2021, 23(11): 4499─4504.

23. Song J G, Su J C, Song Q Y, Huang R L, Tang W, Hu L J, Huang X J, Jiang R W, Li Y L, Ye W C*, Wang Y*. Cleistocaltones a and b, antiviral phloroglucinol-terpenoid adducts from cleistocalyx operculatus. Organic Letters, 2019, 21(23): 9579─9583.

24. Deng Q, Liu Y, Li X, Yan B, Sun X, Tang W, Trang P, Yang Z, Gong H, Wang Y, Lu J, Chen J, Xia C, Xing X W*, Lu S W*, Liu F*. Inhibition of human cytomegalovirus major capsid protein expression and replication by ribonuclease p-associated external guide sequences. RNA, 2019, 25(5): 645─655.

25. Chen L F, Zhong Y L, Luo D, Liu Z, Tang W, Cheng W, Xiong S, Li Y L*, Li M M*. Antiviral activity of ethanol extract of lophatherum gracile against respiratory syncytial virus infection. Journal of Ethnopharmacology, 2019, 242: 111575.

主持及参与的科研项目：

1. 国家自然科学基金(项目编号：82003610，主持)

2. 广东省自然科学基金(项目编号：2023A1515011113，主持)

3. 中国博士后科学基金(项目编号：2020M683208，主持)

4.  暨南大学青年科技人才托举工程项目(项目编号21624224，主持)

5. 广州市基础研究计划项目“青年博士启航项目”(项目编号：SL2024A04J01337，主持)

6. 国家自然科学基金重大项目(项目编号：82293681，项目骨干)

7. 广东省自然科学基金-卓越青年团队项目(项目编号：2024B1515040014，项目骨干)

8. 广东省基础与应用基础研究基金(项目编号：2022B1515120015，项目骨干)

9. 广东省重点领域研发计划项目(项目编号：2021B1111110004，项目骨干)

10. 国家自然科学基金(项目编号：82173695，项目骨干)

11. 国家自然科学基金(项目编号：82074133，项目骨干)

12. 国家自然科学基金(项目编号：82073895，项目骨干)

13. 国家自然科学基金(项目编号：81973190，参与)

14. 国家自然科学基金(项目编号：81673670，参与)

专利：

1.  酰基烷聚酮化合物及其制备方法和应用.中国发明专利, ZL202311322240.9. 已授权

2.  呼吸道合胞病毒融合前F蛋白突变体及其应用.中国发明专利, ZL202310868784.9. 已授权

3. 一类多环苯并双呋喃化合物及其作为抗RSV药物中的应用.中国发明专利, ZL202011093853.6.(PCT号: PCT号: PCT/CN2021/121948). 已授权

4. 一类多环聚酮化合物在制备抗新型冠状病毒药物中的应用.中国发明专利, ZL202010799867.3 (PCT号：PCT/CN2021/105596).已授权

5.  一类多环聚酮化合物在制备抗疱疹病毒药物中的应用.中国发明专利, ZL201910468338.2. 已授权

6. Rhodomyrtone干粉及其干粉吸入剂及其制备方法.中国发明专利, CN202211287781.8

7. Rhodomyrtone吸入混悬液及其制备方法.中国发明专利, CN202311664867.2

8.  一种环三醇衍生物及其制备方法与应用,中国发明专利, ZL201910533233.0. 已授权

9.  一种奎宁酸衍生物及其制备方法与应用,中国发明专利, ZL201910532392.9. 已授权

10.  一种羟基环己二酰胺类化合物及其制备方法与应用, 中国发明专利, ZL202111384289.8. 已授权

11. 环聚酮-萜类加合物、制备方法及其应用, 中国发明专利, CN202410321304.1

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