唐维,博士。2015年6月毕业于暨南大学药物化学专业,获硕士学位。2017年3月-2019年3月获国家留学基金委公派资助,赴加州大学伯克利分校进行博士联合培养学习。2019年6月毕业于暨南大学中药化学专业,获医学博士学位,同年进入暨南大学中西医结合博士后科研流动站完成博士后研究工作。2022年入职暨南大学药学院,主要从事抗病毒活性成分发现及其作用机制研究,主持国家自然科学基金青年基金1项、广东省自然科学基金面上项目1项、中国博士后基金面上项目1项,作为项目骨干参与国家自然科学基金重大项目1项。已在Journal of Virology、FASEB Journal、Journal of Organic Chemistry、Frontiers in Microbiology等本领域专业期刊发表与抗病毒活性成分研究有关的SCI论文20余篇,包括(共)第一作者或共通讯作者论文8篇。申请PCT专利2项、中国发明专利7项(获授权5项)。
主要研究方向:
1. 抗病毒活性成分发现及其作用机制研究
2. 呼吸道病毒融合蛋白相关研究
近五年发表的论文:
1. Tang W#, Li Y Y#, Song Q Y, Wang Z Q, Li M M, Zhang Q W, Wang Y*, Ye W C*, Li Y L*. Mechanism of cross-resistance to fusion inhibitors conferred by the K394R mutation in respiratory syncytial virus fusion protein. Journal of Virology, 2021,95(20): e01205─01221.
2. He J#, Huang H#, Li B, Li H, Zhao Y, Li Y, Ye W, Qi W, Tang W*, Wang L*. Identification of cytochrome c oxidase subunit 4 isoform 1 as a positive regulator of influenza virus replication. Frontiers in Microbiology, 2022, 13: 862205.
3. Tang W#, Li M M#, Liu Y J, Liang N, Yang Z, Zhao Y X, Wu S, Lu S W, Li Y L*, Liu F Y*. Small molecule inhibits respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane. FASEB Journal, 2019, 33(3): 4287─4299.
4. Deng L M#, Hu L J#, Tang W#, Liu J, Huang X J, Li Y L, Li Y Y, Ye W C*, Wang Y*. A Biomimetic synthesis-enabled stereochemical assignment of rhodotomentones A and B, two unusual caryophyllene-derived meroterpenoids from Rhodomyrtus tomentosa. Organic Chemistry Frontiers, 2021, 8(20): 5728─5735.
5. Deng L M#, Tang W#, Wang S Q, Song J G, Huang X J, Zhu H Y, Li Y L, Ye W C*, Hu L J*, Wang Y*. Discovery and Biomimetic Synthesis of a Polycyclic Polymethylated Phloroglucinol Collection from Rhodomytus tomentosa. The Journal of Organic Chemistry. 2022. 87(7): 4788─4800.
6. Chen L F, Xu W B, Li Y Y, Chen N H, Luo D, Song Q Y, Tang W, Huang Z G, Li Y L*, Liu Z*, Li M M*. Inhibitory effect of PIK-24 on respiratory syncytial virus entry by blocking phosphatidylinositol-3 kinase signaling. Antimicrobial Agents and Chemotherapy, 2020, 64(10).
7. Yang W Q#, Tang W#, Huang X J, Song J G, Li Y Y, Xiong Y, Fan C L, Wu Z L*, Wang Y*, Ye W C. Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities. Molecules.2021, 26(19): 5939.
8. Song J G#, Tang W#, Wang X, Su J C, Huang X J, Shi L, Ye W C* , Wang Y*. Phloroglucinol-derived lipids from the leaves of syzygium cumini and their neuroprotective activities. Fitoterapia, 2021, 153: 104968.
9. Deng L M, Hu L J, Bai Y T, Wang J, Qin G Q, Song Q Y, Su J C, Huang X J, Jiang R W, Tang W, Li C C*, Ye W C*, Wang Y*. Rhodomentosones a and b: Two pairs of enantiomeric phloroglucinol trimers from rhodomyrtus tomentosa and their asymmetric biomimetic synthesis. Organic Letters, 2021, 23(11): 4499─4504.
10. Song J G, Su J C, Song Q Y, Huang R L, Tang W, Hu L J, Huang X J, Jiang R W, Li Y L, Ye W C*, Wang Y*. Cleistocaltones a and b, antiviral phloroglucinol-terpenoid adducts from cleistocalyx operculatus. Organic Letters, 2019, 21(23): 9579─9583.
11. Deng Q, Liu Y, Li X, Yan B, Sun X, Tang W, Trang P, Yang Z, Gong H, Wang Y, Lu J, Chen J, Xia C, Xing X W*, Lu S W*, Liu F*. Inhibition of human cytomegalovirus major capsid protein expression and replication by ribonuclease p-associated external guide sequences. RNA, 2019, 25(5): 645─655.
12. Chen L F, Zhong Y L, Luo D, Liu Z, Tang W, Cheng W, Xiong S, Li Y L*, Li M M*. Antiviral activity of ethanol extract of lophatherum gracile against respiratory syncytial virus infection. Journal of Ethnopharmacology, 2019, 242: 111575.
13. Li W, Liu Y, Wang Y, Li R, Trang P, Tang W, Yang Z, Wang Y, Sun X, Xing X W*, Lu S W*, Liu F Y*. Engineered rnase p ribozymes effectively inhibit the infection of murine cytomegalovirus in animals. Theranostics, 2018, 8(20): 5634─5644.
14. Zhuang L, Chen L F, Zhang Y B, Liu Z, Xiao X H, Tang W, Wang G C, Song W J, Li Y L*, Li M M*. Watsonianone a from rhodomyrtus tomentosa fruit attenuates respiratory-syncytial-virus- induced inflammation in vitro. Journal of Agricultural and Food Chemistry, 2017, 65(17): 3481─3489.
主持及参与的科研项目:
1. 国家自然科学基金(项目编号:82003610,主持)
2. 中国博士后科学基金(项目编号:2020M683208,主持)
3. 广东省自然科学基金面上项目(项目编号:2023A1515011113,主持)
4. 国家自然科学基金重大项目(项目编号:82293681,项目骨干)
5. 广东省重点领域研发计划项目(项目编号:2021B1111110004,项目骨干)
6. 广东省基础与应用基础研究基金(项目编号:ZX20230013,项目骨干)
7. 国家自然科学基金(项目编号:82173695,项目骨干)
8. 国家自然科学基金(项目编号:82074133,项目骨干)
9. 国家自然科学基金(项目编号:82073895,项目骨干)
10. 国家自然科学基金(项目编号:81973190,参与)
11. 国家自然科学基金(项目编号:81673670,参与)
专利:
已授权的中国发明专利,专利编号:(1) ZL201910468338.2、(2) ZL202011093853.6、(3) ZL202010799867.3、(4) ZL201910532392.9、(5) ZL201910533233.0