您当前位置: 首页  师资队伍  教师名单  副教授

张世卿

发布时间:2022-05-08 发布单位:药学院

1、个人简介:

张世卿,博士,副研究员。2009年毕业于南方医科大学中药学专业,获学士学位;2012年获南方医科大学中药药理学硕士学位;2016年获香港浸会大学神经生物学博士学位,同年在香港浸会大学理学院进行博士后研究;2019年获聘为香港浸会大学理学院研究助理教授;2021年进入暨南大学药学院工作。主要研究神经退行性疾病病理机制及药物干预策略,善于利用中药及天然药物有效成分治疗神经退行性疾病。以第一作者/通讯作者在Advanced ScienceActa Pharmacologica SinicaJ Ginseng ResPhytomedicineFront Pharmacol等期刊发表论文多篇。主持国家自然科学基金青年科学基金项目1项及广东省自然科学基金面上项目1项。荣获日本癌症协会青年科学家奖,代表香港参加第70届林道诺贝尔奖得主大会。

2、讲授课程:

1)《Pharmacology

 3、研究方向:

1)神经药理学

2)神经系统疾病发病机制

3)天然药物活性成分发现

 4、代表性科研项目:

1)国家自然科学基金青年科学基金项目(81703728),基于GSK-3β途径探索人参及其有效成分促进神经干细胞增殖和分化治疗老年痴呆症的机制(20181-202012月,20

2)广东省自然科学基金面上项目(2019A151501197),基于Wnt/β-catenin通路探讨远志皂苷元的促神经发生作用及其治疗阿尔兹海默病的研究(201910-20229月,10

5、代表性论文

[1] Jiang XL#, Deng B#, Deng SH#, Cai M, Tian ZB, Chen RX, Xu YC, Ding WJ, Xu HL, Zhang SW, Zhang SQ*, Liu B*, Zhang JZ*. Dihydrotanshinone I inhibits the growth of hepatoma cells by direct inhibition of Src. Phytomedicine. 2022, 95:153705.

[2] Wu X Y#, Lv J Y#, Zhang SQ#, Yi X, Xu ZW, Zhi YX, Zhao BX, Pang JX, Yung K*, Liu SW*, Zhou PZ*. ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome. Acta pharmacologica Sinica. 2021, 10.1038/s41401-021-00739-9.

[3] Zhang SQ#, Jiang XL#, Wang Y, Lin KL, Zhang Z, Zhang Z, Ng ML, Qu SG, Sze SCW*, Yung KKL*. Protective Effect of An-Gong-Niu-Huang Wan Pre-treatment against Experimental Cerebral Ischemia Injury via Regulating GSK-3β/HO-1 Pathway. Frontiers in Pharmacology. 2021, 16, 640297.

[4] Lin KL#, Sze SCW#, Liu B, Zhang Z, Zhang Z, Zhu PL, Wong Y, Deng QD, Yung KKL*, Zhang SQ*. 20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis. Journal of Ginseng Research. 2021, 45: 325-333.

[5] Zhang SQ#, Sun P#, Lin K#, Chan FHL, Gao Q, Lau WF, Roy VAL, Zhang HQ, Lai KWC*, Huang ZF*, Yung KKL*. Extracellular nanomatrix-induced self-organization of neural stem cells into miniature substantia nigra-like structures with therapeutic effects on Parkinsonian rats. Advanced Science. 2019, 6(24): 1901822.

[6] Lin KL#, Liu B#, Lim SL, Fu XQ, Sze SCW, Yung KKL*, Zhang SQ*. 20(S)-protopanaxadiol promotes the migration, proliferation and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin pathway. Journal of Ginseng Research. 2020, 44: 475-482.

[7] Zhang Z#, Zhang SQ#, Lui CNP, Zhu PL, Zhang Z, Lin KL, Dai YW*, Yung KKL*. Traditional Chinese medicine-based neurorestorative therapy for Alzheimer’s and Parkinson’s disease. Journal of Neurorestoratology. 2019, 07: 207-222.

[8] Zhang Zhu#, Zhang SQ#, Fu PF, Zhang Z, Lin KL, Ko JKS*, Yung KKL*. Roles of Glutamate Receptors in Parkinson’s Disease. International Journal of Molecular Sciences. 2019, 20(18), 4391.

[9] Lv JY#, Liang YM#, Zhang SQ#, Lan QS, Xu ZW, Wu XY, Kang LJ, Ren J, Cao Y, Wu T, Lin KL, Yung KKL, Cao X*, Pang JX*, Zhou PZ*. DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels. ACS Chemical Neuroscience. 2019, 10:2786-2793.

[10] Zhang SQ#, Yung KK#, Chung SK, Chung SS*. Aldo-keto reductases mediated cytotoxicity of 2-deoxy-d-glucose: a novel anticancer mechanism. Cancer Science. 2018, 109(6): 1970-1980.

6、代表性专利:

1Yung K.K.L., Huang Z.F., Zhang S.Q. Biocompatible sculptured extracellular nanomatrix enables self assembly of neural stem cells into miniature brain organoids of substantia nigra, 2018.04.12, 美国专利, 16/209,934.

7、联系方式:

联系邮箱:sqzhang@jnu.edu.cn