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田丹妹

发布时间:2022-05-08 发布单位:药学院

1、个人简介:

田丹妹,理学博士,副研究员,硕士生导师。20126月毕业于沈阳药科大学中药学院中药学专业,获学士学位;20176月获沈阳药科大学中药学院天然药物化学专业博士学位;20179月,在暨南大学药学院中药学科研博士后流动站从事博士后研究。20213月入职暨南大学药学院。长期从事活性天然产物的发现及机制研究相关工作,主持国家自然科学基金青年基金1项,广州市科技计划项目1项;发表学术论文19篇,其中包括以(共)第一/(共)通讯作者在Cancer LettersJournal of Natural ProductsMarine Drugs 等杂志发表的文章 9篇;申请发明专利3项。


2、研究方向:

(1)从中药及微生物中寻找活性化合物

(2)活性化合物作用机制研究



3、主持及参与的科研项目:

(1)国家自然科学基金委员会,青年科学基金项目,81903482,强心苷探针的设计、合成及其增强KRAS突变型肺癌对化疗药敏感性的靶标研究,2020-01-01 2022-12-3121万元,在研,主持

(2)国家自然科学基金委员会,青年科学基金项目,81803347,靶向抗乙型肝炎病毒相关性肝细胞癌NTCP抑制剂的设计、合成与构效关系研究,2019-01-01 2021-12-3120.5万元,结题,参与

(3)中华人民共和国科学技术部,国家重点研发计划,2018YFC0311003,海洋微生物候选药物的高效发现与创制(课题3 高通量新靶点抗细菌、癌症耐药先导物的筛选与评价),2018-08 2021-12341.00万元,结题,参与


4、代表性文章:

(1)Tian, Danmei#; Gou, Xiaoshuang#; Jia, Jia; Wei, Jihua; Zheng, Mingxin; Ding, Wenjuan; Bi, Hongkai*; Wu, Bin*; Tang, Jinshan*.New diketopiperazine alkaloid and polyketides from marine-derived fungus Penicillium sp. TW58-16 with antibacterial activity against Helicobacter pylori. Fitoterapia (2022), 156, 105095.

(2)Gou, Xiaoshuang#; Tian, Danmei#; Wei, Jihua#; Ma, Yihan; Zhang, Yixue; Chen, Mei; Ding, Wenjuan; Wu, Bin*; Tang, Jinshan*. New drimane sesquiterpenes and polyketides from marine-derived fungus Penicillium sp. TW58-16 and their anti-inflammatory and α-glucosidase inhibitory effects. Marine Drugs (2021), 19(8), 416.

(3)Tian, Danmei#; Cao, Lingyun#; Li, Qingwen; Huang, Huiyun; Xu, Wei; Chen, Guodong*; Song, Zhaohui; He, Yi; Yao, Xinsheng; Tang, Jinshan*. Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens. Bioorganic Chemistry (2021), 107, 104604.

(4)Tian, Danmei#; Tang, Jinshan#*; Geng, Xinran#; Li, Qingwen; Wang, Fangfang; Zhao, Huadong; Narla, Goutham; Yao, Xinsheng*; Zhang, Youwei*. Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy. Cancer Letters (New York, NY, United States) (2020), 493, 80-90.

(5)Tian, Dan-mei; Qiao, Jia; Bao, Yu-zhou; Liu, Jie; Zhang, Xiao-kun; Sun, Xue-long; Zhang, You-wei; Yao, Xin-sheng*; Tang, Jin-shan*. Design and synthesis of biotinylated cardiac glycosides for probing Nur77 protein inducting pathway. Bioorganic & Medicinal Chemistry Letters (2019), 29(5), 707-712.

(6)Li, Jingwen#; Duan, Menglong#; Yao, Xinsheng; Tian, Danmei*; Tang, Jinshan*. Prenylated benzenepropanoic acid analogues from the Citrus grandis (L.) Osbeck and their anti-neuroinflammatory activity. Fitoterapia (2019), 139, 104410.

(7)Tian, Danmei#; Wang, Fangfang#; Duan, Menglong; Cao, Lingyun; Zhang, Youwei; Yao, Xinsheng*; Tang, Jinshan*. Coumarin analogues from the Citrus grandis (L.) Osbeck and their hepatoprotective activity. Journal of Agricultural and Food Chemistry (2019), 67(7), 1937-1947.

(8)Tian, Dan-Mei; Cheng, Huo-Yun; Jiang, Miao-Miao; Shen, Wei-Zai; Tang, Jin-Shan*; Yao, Xin-Sheng*. Cardiac Glycosides from the Seeds of Thevetia peruviana. Journal of Natural Products (2016), 79(1), 38-50.

(9)Cheng, Huo-Yun#; Tian, Dan-Mei#; Tang, Jin-Shan; Shen, Wei-Zai*; Yao, Xin-Sheng*.Cardiac glycosides from the seeds of Thevetia peruviana and their pro-apoptotic activity toward cancer cells. Journal of Asian Natural Products Research (2016), 18(9), 837-847.


5、联系方式:

邮箱:danmeitian@jnu.edu.cn