您当前位置: 首页  师资队伍  教师名单  教授

李怡芳

发布时间:2021-10-12 发布单位:药学院



李怡芳,暨南大学药学院教授、博士生导师,暨南大学广东省疾病易感性及中医药研发工程技术研究中心副主任,兼任Acta Pharm Sin BChin J Nat MedTrad Med Res期刊青年编委等社会职务。

入选国家教育部重大人才项目青年学者、广东省自然科学基金杰出青年、广东省特支计划青年拔尖人才、广州市珠江科技新星等人才项目。主要从事免疫分子机制研究、免疫药理学、中药抗感染药理研究。相关研究获得国家自然科学基金、广东省自然科学基金等6项省部级以上课题资助,申请专利10余项,研究成果获得广东省科技进步一等奖(排名第2)、教育部高等学校科技进步二等奖(排名第2)及中国专利优秀奖(排名第3),在Nat CommunCell Death &DiffSignal Transduct Target TherRedox BiolActa Pharm Sin BTheranostics等期刊上发表论文60多篇。



主要研究方向:

1.药理学(免疫药理学、抗病毒药理学、中药抗感染药理学)

  

教育和工作经历:

 2003/09–2007/07:江西中医药大学,药学院,药学/学士

 2007/09–2010/06:暨南大学,药学院,药理学/硕士

 2010/09–2013/06:暨南大学,药学院,生物医药工程/博士

 2013/07–2015/09:暨南大学,药学院,讲师

 2015/10–2020/09:暨南大学,药学院,副教授

 2020/10–至今:暨南大学,药学院,教授


主要学术奖励:

  1. 广东省科技进步一等奖,2018年,排名第二

  2. 教育部科学技术进步二等奖,2018年,排名第二

  3. 中国专利优秀奖,2015年,排名第三


  获人才项目:

  1. 国家级人才项目(2020年):教育部重大人才项目青年学者

  2. 省级人才项目(2017年):广东省特支计划青年拔尖人才

  3. 省级人才项目(2017年):广东省自然科学杰出青年

  4. 市级人才项目(2016年):广州市珠江科技新星计划


近年发表的主要英文论文

  1. Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS. Signal Transduct Target Ther. 2020, 5(1):202. (IF=13.493)

  2. Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. Cell Death Differ. 2021, 28(6):1971-1989 (IF=15.828)

  3. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea. Nat Commun. 2020 11(1):1473. (IF=14.919)

  4. Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage. Redox Biol. 2018, 14:1-6. (IF=11.799)

  5. Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone. Theranostics. 2020 Jul 11;10(20):9032-9049.  (IF=11.556)

  6. Caffeine protects skin from oxidative stress-induced senescence through the activation of autophagy. Theranostics. 2018; 8(20):5713-5730. (IF=11.556)

  7. Inhibitory effects of baicalein against herpes simplex virus type 1. Acta Pharm Sin B. 2020,Dec 10(12):2323-2338. (IF=11.413)

  8. Disturbed Yin-Yang balance: stress increases the susceptibility to primary and recurrent infections of herpes simplex virus type 1. Acta Pharm Sin B. 2020 Mar 10(3):383-398. (IF=11.413)

  9. Celastrol ameliorates Propionibacterium acnes/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3. Phytomedicine, 2021, 80:153398.

  10. New insights into the effects and mechanism of a classic traditional Chinese medicinal formula on influenza prevention. Phytomedicine. 2017, 27:52-62.

  11. Fostering efficacy and toxicity evaluation of traditional Chinese medicine and natural products: Chick embryo as a high throughput model bridging in vitro and in vivo studies. Pharmacol Res.2018,133:21-34. (IF=7.658)

  12. A comparative analysis of chemical compositions in Camellia sinensis var. puanensis Kurihara, a novel Chinese tea, by HPLC and UFLC-Q-TOF-MS/MS. Food Chem.2017. 216:282-8.(IF= 7.514)

  13. Shanghuo” increases disease susceptibility: Modern significance of an old TCM theory. Journal of Ethnopharmacology.2020, 250:112491.

  14. Traditional Chinese Medicine as a Potential Source for HSV-1 Therapy by Acting on Virus or the Susceptibility of Host. INT J MOL SCI . 2018, 19: 3266-3288.

  15. Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro. Front Pharmacol. 2019 Feb 7;10:78.

  16. Sirt3-dependent deacetylation of COX-1 counteracts oxidative stress–induced cell apoptosis. The FEBS Journal 2019, 33(22): 14118-14128.

  17. Shanghuo” increases disease susceptibility: Modern significance of an old TCM theory. Journal of Ethnopharmacology.2020, 250: 112491.

  18. Clinical Prescription-Protein-Small Molecule-Disease Strategy (CPSD), A New Strategy for Chinese Medicine Development: A Case Study in Cardiovascular Diseases. Front. Pharmacol.2020, 10: 1564.

  19. Immune regulation effect of lienal polypeptides extract in Lewis lung carcinoma-bearing mice treated with cyclophosphamide. Exp Biol Med.2018, 243(1):66-77.

  20. Theacrine protects against nonalcoholic fatty liver disease by regulating acylcarnitine metabolism. Metabolism.2018,85:227-39.



联系方式:

地址:广州黄埔大道西 601号 暨南大学 药学院七楼  

Emailliyifang706@jnu.edu.cn