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周洋

发布时间:2023-04-10 发布单位:药学院


  

    1. 个人简介:

周洋,理学博士,硕士研究生导师。主要研究方向为药物设计中计算方法及应用,包括激酶相关药物设计、生物活性分子结合/解离过程的分子机制、靶标蛋白构象变化、基于靶标动态变化的药物设计,以及人工智能在药物研发领域的应用。已在国际知名期刊发表论文50余篇,其中第一作者和共同通讯作者在Nat. Commun.J. Med. Chem.Chem CommunJ. Chem. Inf. ModelEur J. Med. Chem等国际主流杂志发表计算及药物设计论文20余篇。


    2. 教育与工作经历:

2021-至今 暨南大学药学院,副研究员

2020-2021 瑞典乌普萨拉大学,博士后

2016-2020瑞典皇家理工学院,计算化学与生物学,博士

2012-2016中国科学院大学,药物化学,硕士

2007-2011天津大学,化学工程与工艺,学士,法学双学位


    3. 讲授课程:

1研究生课程《新药研究与计算机辅助药物设计》

2研究生课程《药学前沿进展》

3研究生课程《科研论文写作》

4研究生课程《药物化学专论》


    4. 近期科研项目:

(1)国家自然科学基金青年科学基金项目(82103968),结核菌呼吸链细胞色素bd氧化酶(Cyt-bd)抑制剂的设计、合成与生物活性研究(项目负责人,2022.01-2024.12

(2)暨南大学中央高校基本科研业务青年培育项目(21621013),新型抗结核药物的设计合成及活性研究(项目负责人,2021.01-2023.12

(3)广州市基础与应用基础研究项目(2023年度),基于计算设计的ZAK激酶不可逆抑制剂发现研究(项目负责人,2023.4-2025.3


    5. 近期获奖情况:

(1)2022年粤港澳大湾区大学生创业大赛优胜奖

(2)2022年珠澳大学生创业大赛铜奖

(3)2022年互联网+大学生创新创业大赛银奖

(4)2021年互联网+大学生创新创业大赛铜奖


    6. 近5年代表性论文:

(1)Chen, Y.; Wang, Y.; Xu, Y.; Sun, J.; Yang, L.; Feng, C.; Wang, J.; Zhou, Y.*; Zhang, Z. M. *; Wang, Y*. Molecular Insights into the Catalytic Mechanism of Plasticizer Degradation by a Monoalkyl Phthalate Hydrolase. Commun. Chem. 2023 61 2023, 6 (1), 1–7.  

(2)Lin, Y.; Shi, Q.; Yang, G.; Shi, F.; Zhou, Y.; Wang, T.; Xu, P.; Li, P.; Liu, Z.; Sun, H.; Zhao, Z.; Ding, K.; Wang, Z.; Feng, H.; Yu, B.; Fang, P.; Wang, J. A Small-Molecule Drug Inhibits Autophagy Gene Expression through the Central Regulator TFEB. Proc. Natl. Acad. Sci. U. S. A. 2023, 120 (7), e2213670120.  

(3)Zhou, Y.; Shao, M.; Wang, W.; Cheung, C. Y.; Wu, Y.; Yu, H.; Hu, X.; Cook, G. M.; Gong, H.; Lu, X. Discovery of 1-Hydroxy-2-Methylquinolin-4(1H)-One Derivatives as New Cytochrome Bd Oxidase Inhibitors for Tuberculosis Therapy. Eur. J. Med. Chem. 2023, 245, 114896.  

(4)Zhang, Z.; Li, J.; Chen, H.; Huang, J.; Song, X.; Tu, Z. C.; Zhang, Z.; Peng, L.*; Zhou, Y.*; Ding, K. * Design, Synthesis, and Biological Evaluation of 2-Formyl Tetrahydronaphthyridine Urea Derivatives as New Selective Covalently Reversible FGFR4 Inhibitors. J. Med. Chem. 2022, 65 (4), 3249–3265.  

(5)Wang, Y.; Zhou, Y.*; Shi, C.; Liu, J.; Lv, G.; Huang, H.; Li, S.; Duan, L.; Zheng, X.; Liu, Y.; Zhou, H.; Wang, Y.; Li, Z.; Ding, K.; Sun, P.; Huang, Y.; Lu, X.; Zhang, Z. M. A Toxin-Deformation Dependent Inhibition Mechanism in the T7SS Toxin-Antitoxin System of Gram-Positive Bacteria. Nat. Commun. 2022, 13 (1), 1–13. (*co-first author)

(6)Zhou, Y.; Li, J.; Baryshnikov, G.; Tu, Y. Unraveling the Abnormal Molecular Mechanism of Suicide Inhibition of Cytochrome P450 3A4. J. Chem. Inf. Model. 2022, 62 (23), 6172–6181.  

(7)Zhou, Y.; Xiang, S.; Yang, F.; Lu, X. Targeting Gatekeeper Mutations for Kinase Drug Discovery. J. Med. Chem. 2022, 65 (23), 15540–15558.  

(8)Wang, Z.; Ran, T.; Xu, F.; Wen, C.; Song, S.; Zhou, Y.*; Chen, H. *; Lu, X. * Deep Learning-Driven Scaffold Hopping in the Discovery of Akt Kinase Inhibitors. Chem. Commun. 2021, 57 (81), 10588–10591.  

(9)Zhou, Y.; Li, J.; Nordberg, A.; Ågren, H. Dissecting the Binding Profile of PET Tracers to Corticobasal Degeneration Tau Fibrils. ACS Chem. Neurosci. 2021, 12 (18), 3487–3496.  

(10)Zhou, Y.; Zou, R.; Kuang, G.; Långström, B.; Halldin, C.; Ågren, H.; Tu, Y. Enhanced Sampling Simulations of Ligand Unbinding Kinetics Controlled by Protein Conformational Changes. J. Chem. Inf. Model. 2019, 59 (9), 3910–3918.  

(11)Zhou, H.; Zhou, Y.*; Xu, J.; Liu, L.; Ma, J.; Zhang, W.; Li, K.; Zhang, H.; Li, K. Tannic Acid-A Universal Immobilization and Fixation Agent for Nanocarbon Materials: A Novel Strategy for Aqueous Fabrication of Functional Nanocarbon Coating onto Silicon-Based Substances. ACS Sustain. Chem. Eng. 2019, 7 (22), 18534–18541. (*co-first author)

(12)Ti, H.; Zhou, Y.*; Liang, X.; Li, R.; Ding, K.; Zhao, X. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). J. Med. Chem. 2019, 62 (13), 5944–5978. (*co-first author)

(13)Zhou, Y.; Hussain, M.; Kuang, G.; Zhang, J.; Tu, Y. Mechanistic Insights into Peptide and Ligand Binding of the ATAD2-Bromodomain via Atomistic Simulations Disclosing a Role of Induced Fit and Conformational Selection. Phys. Chem. Chem. Phys. 2018, 20 (36), 23222–23232.

(14)Zhao, X.; Li, R.; Zhou, Y.*; Xiao, M.; Ma, C.; Yang, Z.; Zeng, S.; Du, Q.; Yang, C.; Jiang, H.; et al. Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses. J. Med. Chem. 2018, 61 (12), 5187–5198. (*co-first author)

(15)Hussain, M.; Zhou, Y.*; Song, Y.; Hameed, H. M. A.; Jiang, H.; Tu, Y.; Zhang, J. ATAD2 in Cancer: A Pharmacologically Challenging but Tractable Target. Expert Opinion on Therapeutic Targets. 2018, pp 85–96. (*co-first author)


    7. 联系方式:

暨南大学药学院514

电子邮箱:zhouyang@jnu.edu.cn