1、个人简介:
钟海静,博士,副教授,硕士生导师。目前已发表SCI论文58篇,其中第一作者(共同一作)18篇,通讯作者2篇。单篇最高影响因子为54.56,累计影响因子逾300,H-index=31 (Scopus),单篇最高他引次数逾250次,累计被引逾2900次,外文专著章节2篇,美国授权专利1项,美国临时专利1项。
教育经历
2012 - 2016 博士(生物医药),澳门大学中华医药研究院
2011 - 2012 硕士(中药学),澳门大学中华医药研究院
2007 - 2011 学士(药学),暨南大学国际学院
工作经历
2019 - 至今 暨南大学药学院新药研究所,副教授
2017 - 2019 访问学者/客座研究员(生物医药),耶鲁大学药理学,师从郑永齐讲席教授
2016 - 2018 博士后,澳门大学中华医药研究院
2、讲授课程:
(1)《药理学》
(2)《药学实践》
3、研究方向:
(1)Discovery of potent natural products, or synthesized compounds with anti-tumor/anti-inflammatory activities
(2)Targeted Drug Delivery System for Cancer Therapy
(3)Theragnostic platforms development
4、主要学术兼职:
(1)广东省自然科学基金杰出青年项目评审专家
(2)广东省基础与应用基础研究基金项目评审专家
(3)国际中医药学会会员
(4)中华中医药学会会员
(5)广东省药学会生物医药分析专业委员会委员
(6)广东省药品食品智能制造工程学会委员
(7)Frontiers in Immunology (IF=7.561)主题专刊客座主编
(8)Journal of Exploratory Research in Pharmacology编委
(9)Traditional Medicine Research 青年编委
(10)The Innovation 青年编委
5、主要获奖情况:
(1)2021年,第三届中华医药创新创业大赛三等奖。
(2)2017年,“中国分析测试协会科学技术奖三等奖”,《基于G-四链体的无标记磷光检测平台在环境及生物分析中的应用》,马迪龙、梁重恒、何鸿章、梁嘉豪、鲁莉华、钟海静、王茉荻、林晟、王万河
(3)2016年,澳门特别行政区研究生科技研发奖,
(4)2016年,The Postdoc-NeT Fellows 2016, 德国学术交流总署(German Academic Exchange Service, DAAD, Germany)
(5)2014年,中药全球化联盟,Travel grant,《Identification of natural product-like protein inhibitors by structure-based virtual screening》
6、代表性科研项目:
(1)广东省基础与应用基础研究基金自然科学基金面上项目(2021A1515012520),创新化合物靶向Ubc12-NEDD8信号通路双功效抗炎症性肠病的机制研究(2021-01-01 至 2023-12-31)
(2)广州市基础与应用基础研究项目(博士青年科技人员类)(33121073),“靶点+活性”发现中药艾叶中靶向Keap1/Nrf2修复肠道屏障的有效成分及作用机制的研究(2021-01-01 至 2023-12-31)
(3)中央高校基本科研业务费(理工医) 青年基金项目(11620355),靶向NRF2高通量筛选天然产物治疗炎症性肠病的研究(2020-01-01至2022-12-31)
7、代表性论文和专著:
(1)Leung C H, Zhong H J, Chan D S H, et al. Bioactive iridium and rhodium complexes as therapeutic agents[J]. Coordination Chemistry Reviews, 2013, 257(11-12): 1764-1776.
(2)Leung C H, Zhong H J, Yang H, et al. A Metal‐Based Inhibitor of Tumor Necrosis Factor‐α[J]. Angewandte Chemie International Edition, 2012, 51(36): 9010-9014.
(3)Zhong H J, Lu L, Leung K H, et al. An iridium (III)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent[J]. Chemical Science, 2015, 6(10): 5400-5408.
(4)Zhong H J, Wang W, Kang T S, et al. A rhodium (III) complex as an inhibitor of neural precursor cell expressed, developmentally down-regulated 8-activating enzyme with in vivo activity against inflammatory bowel disease[J]. Journal of Medicinal Chemistry, 2017, 60(1): 497-503.
(5)Yang G J, Zhong H J(共同一作), Ko C N, et al. Identification of a rhodium (iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells[J]. Chemical Communications, 2018, 54(20): 2463-2466.
(6)Wu K J, Zhong H J(共同一作), Li G, et al. Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing[J]. European journal of medicinal chemistry, 2018, 143: 1021-1027.
(7)Zhong H J, Lee B R, Boyle J W, et al. Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction[J]. Chemical Communications, 2016, 52(34): 5788-5791.
(8)Leung C H, Zhong H J, He H Z, et al. Luminescent oligonucleotide-based detection of enzymes involved with DNA repair[J]. Chemical Science, 2013, 4(10): 3781-3795.
(9)Wang H, Zhong H J(共同一作), Xu X, et al. Catalytic enantioselective bromoaminocyclization and bromocycloetherification[J]. Advanced Synthesis & Catalysis, 2020, 362(23): 5358-5362.
(10)Zhong H J, Leung K H, Liu L J, et al. Antagonism of mTOR activity by a kinetically inert rhodium (III) complex[J]. ChemPlusChem, 2014, 79(4): 508-511.
8、代表性专利:
(1)Leung C H, Zhong H J, Ma D, et al. Iridium (III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent: U.S. Patent 9,840,526[P]. 2017-12-12.
(2)Ma D, Leung C H, Zhong H J, et al. Method of detecting helicase activity: U.S. Patent Application 14/950,538[P]. 2017-5-25.
9、联系方式:
联系邮箱:hjzhong@jnu.edu.cn