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陈卫民，男，教授，博士，博士生导师。现任暨南大学药学院副院长。 学习经历： 1979.9-1983.7 华中工学院（现华中科技大学），理学学士 1987.9-1990.6 同济医科大学，医学硕士 1995.9-1998.12 中山大学，理学博士 2001.6-2003.6 香港中文大学，Research Associate 2015.7-2015.8 澳大利亚国立大学，高级访问学者 工作经历： 1983.8-1990.5 石家庄陆军学院，教师 1990.6-2004. 6 第一军医大学， 讲师、副教授、教授 2004.7- 暨南大学， 教授 陈卫民教授主要从事药物化学和新药研究工作，迄今为止作为课题负责人已承担7项国家自然科学基金和多项省市基金等科研项目；承担和参与了多个新药品种的研制，获国家新药证书5个(包括原料药与制剂)；曾获军队科技进步奖4项、广东省科技进步奖2项。在国内外学术期刊上发表学术论100余篇,其中SCI收录70余篇。科研兴趣包括细菌抗生素耐药与新型抗耐药菌感染药物的设计与合成；天然活性化合物的结构修饰与构效关系研究；以及计算机辅助药物设计等。目前从事药物化学的教学与科研工作，讲授本科生《药物化学》、研究生《高等有机化学》等课程。 现为暨南大学药物化学专业硕士研究生指导教师，中药化学专业博士生指导教师。已毕业硕士和博士研究生57人，在读博士生2人，硕士生7人。在已毕业的研究生中，大部分在国内医药企业或高等学校工作并成长为业务骨干。
1. 新型抗感染药物的设计与合成: 针对细菌抗生素耐药问题，研究新型细菌生物膜抑制剂；新型抗持留菌药物；慢性伤口感染药物；抗菌药物新靶标研究等；
2. 天然活性化合物的结构修饰与活性先导物发现：已开展天然活性化合物如：一叶萩碱、白桦酸、木豆素、沙蟾毒精、小檗碱、川芎嗪等结构修饰，发现了一批具有更优活性的新化合物。
近五年承担的主要科研项目：
1. 国家自然科学基金（81872776）：基于羟基吡啶酮类铁螯合剂以PqsR为靶标的铜绿假单胞菌生物膜抑制剂研究，55万，2019/01-2022/12，项目负责人；
2. 国家自然科学基金（81673336）：基于木豆素为抗菌先导物的抗耐药菌感染药物设计与合成，60万，2017/01-2020/12，项目负责人；
3. 广东省自然科学基金重点项目(2014A030311021), 以木豆素为先导化合物的新型抗菌药物的设计与合成，30万元，2014/10-2016/09，在研，项目负责人；
4. 国家自然科学基金（81273362）：一叶萩型生物碱二聚体的仿生合成及其抗肿瘤作用研究，70万，2013/01-2016/12，项目负责人；
5. 国家自然科学基金（81072554）：基于铜绿假单胞菌生物膜耐药及感染机制的新药设计与合成，35万，2011/01-2013/12，项目负责人；
6. 广东省自然科学基金（S2012010008130）：基于沙蟾毒精结构优化的新型抗肿瘤药物设计与合成，5万，2012/10-2014/10，项目负责人；
7. 教育部高等学校博士学科点专项科研基金（20124401110008）：基于沙蟾毒精结构优化的新型抗肿瘤药物设计与合成，12万元，2013/01-2015/12，，项目负责人。
近五年代表性论文：
1. Liao, Yumei; Zhuang, Xiaoji; Huang, Xiaojie; Peng, Yinghui; Ma, Xuanyue; Huang, Zhi-Xing; Liu, Feng; Xu, Junyu; Wang, Ying; Chen, Wei-Min; Ye, Wen-Cai; Shi, Lei. A Bivalent Securinine Compound SN3-L6 Induces Neuronal Differentiation via Translational Upregulation of Neurogenic Transcription Factors, FRONTIERS IN PHARMACOLOGY, 2018, 9, 290, 10.3389/fphar.2018.00290.
2. Li, Yi-Bin; Hou, Wen; Lin, Hui; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min. Design, synthesis and biological evaluation of novel 5-hydroxy-2-methyl-4H-pyran-4-one derivatives as antiglioma agents, MEDCHEMCOMM, 2018,9(3):471-476.
3. Xu, Xing-Jun; Wang, Fang; Zeng, Ting; Lin, Jing; Liu, Jun; Chang, Yi-Qun; Sun, Ping-Hua; Chen, Wei-Min. 4-arylamidobenzyl substituted 5-bromomethylene-2(5H)-furanones for chronic bacterial infection, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY , 2018，144，164-178.
4. Zheng, Jun-Xia; Han, Yu-Shui; Wang, Jin-Cai; Yang, Hui; Kong, Hao; Liu, Kang-Jia; Chen, Si-Yu; Chen, Yi-Rui; Chang, Yi-Qun; Chen, Wei-Min; Guo, Jia-Liang; Sun, Ping-Hua. Strigolactones: a plant phytohormone as novel anti-inflammatory agents, MEDCHEMCOMM , 2018, 9(1):181-188.
5. Xu, Xingjun; Kim, Hye-Sun; Chen, Wei-Min; Ma, Xiang; Correy, Galen J.; Banwell, Martin G.; Jackson, Colin J.; Willis, Anthony C.; Carr, Paul D. Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 27,4044-4053.
6. Deng, Li-Juan; Wang, Long-Hai; Peng, Cheng-Kang; Li, Yi-Bin; Huang, Mao-Hua; Chen, Min-Feng; Lei, Xue-Ping; Qi, Ming; Cen, Yun; Ye, Wen-Cai; Zhang, Dong-Mei; Chen, Wei-Min. Fibroblast Activation Protein alpha Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity, JOURNAL OF MEDICINAL CHEMISTRY,2017, 60(13):5320-5333.
7. Peng, Cheng-Kang; Zeng, Ting; Xu, Xing-Jun; Chang, Yi-Qun; Hou, Wen; Lu, Kuo; Lin, Hui; Sun, Ping-Hua; Lin, Jing; Chen, Wei –Min. Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017,127,187-199.
8. Hou, Wen; Lin, Hui; Wang, Zhen-Ya; Banwell, Martin G.; Zeng, Ting; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min. Novel bivalent securinine mimetics as topoisomerase I inhibitors, MEDCHEMCOMM, 2017,8(2):320-328.
9. Yao, Nan; Li, Ying-jie; Lei, Yu-he; Hu, Nan; Chen, Wei-Min; Yao, Zhe; Yu, Miao; Liu, Jun-shan; Ye, Wen-cai; Zhang, Dong-mei. A piperazidine derivative of 23-hydroxy betulinic acid induces a mitochondria-derived ROS burst to trigger apoptotic cell death in hepatocellular carcinoma cells, JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2016, 35,192, 10.1186/s13046-016-0457-1.
10. Hou, Wen; Wang, Zhen-Ya; Peng, Cheng-Kang; Lin, Jing; Liu, Xin; Chang, Yi-Qun; Xu, Jun; Jiang, Ren-Wang; Lin, Hui; Sun, Ping-Hua; Chen, Wei-Min. Novel securinine derivatives as topoisomerase I based antitumor agents, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2016, 122, 149-163.
11. Tang, Genyun; Liu, Xin; Ma, Nan; Huang, Xiaojie; Wu, Zhen-Long; Zhang, Wen; Wang, Ying; Zhao, Bing-Xin; Wang, Zhen-Ya; Ip, Fanny C. F.; Ip, Nancy Y.; Ye, Wen-Cai; Shi, Lei; Chen, Wei-Min. Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities, ACS CHEMICAL NEUROSCIENCE, 2016,7(10):1442-1451.
12. Huang, Mei-Yan; Lin, Jing; Lu, Kuo; Xu, Hong-Gui; Geng, Zhi-Zhong; Sun, Ping-Hua; Chen, Wei-Min. Anti-Inflammatory Effects of Cajaninstilbene Acid and Its Derivatives, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2016,64(14):2893-2900.
13. Huang, Mei-Yan; Lin, Jing; Huang, Zhi-Jian; Xu, Hong-Gui; Hong, Juan; Sun, Ping-Hua; Guo, Jia-Liang; Chen, Wei-Min. Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives, MEDCHEMCOMM, 2016 ,7(4):658-666.
14. Zhang, Dong-Mei; Xu, Hong-Gui; Wang, Lei; Li, Ying-Jie; Sun, Ping-Hua; Wu, Xiao-Ming; Wang, Guang-Ji; Chen, Wei-Min; Ye, Wen-Cai. Betulinic Acid and its Derivatives as Potential Antitumor Agents, MEDICINAL RESEARCH REVIEWS, 2015, 35(6):1127-1155.
15. Chen, Yan; Ruan, Zhi-Xiong; Wang, Fang; Huangfu, De-Sheng; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min. Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C-ring Unit, CHEMICAL BIOLOGY & DRUG DESIGN, 2015,86(4):682-690.
16. Geng, Zhi-Zhong; Zhang, Jian-Jun; Lin, Jing; Huang, Mei-Yan; An, Lin-Kun; Zhang, Hong-Bin; Sun, Ping-Hua; Ye, Wen-Cai; Chen, Wei-Min. Novel cajaninstilbene acid derivatives as antibacterial agents, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015,100, 235-245 .
17. Wang, Fang; Lin, Jing; Hou, Wen; Huang, Mei-Yan; Sun, Ping-Hua; Chen, Wei-Min. 5-Benzylidene-3,4-dihalo-furan-2-one Derivatives Inhibit Human Leukemia Cancer Cells Through Suppression of NF-kappa B and GSK-3 beta, ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2015, 15(6):744-754.
18. Hu, Yu-Quan; Li, Chen; Zhao, Bing-Xin; Li, Jun-Yong; Huang, Xiao-Jun; Lin, Jing; Wang, Ying; Ye, Wen-Cai; Chen, Wei-Min . Regioselective and stereoselective photodimerization of securinine-type and norsecurinine-type alkaloids , TETRAHEDRON, 2014, 70(33):4903-4909.
19. Wang, Fang; Sun, Jun-Rong; Huang, Mei-Yan; Wang, Hui-Ying; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min. Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivatives , EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014,72,35-45.
20. Shan, Ling-Xing; Sun, Ping-Hua; Guo, Bao-Qin; Xu, Xing-Jun; Li, Zhi-Qiang; Sun, Jia-Zhi; Zhou, Shu-Feng; Chen, Wei-Min. Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chain, DRUG DESIGN DEVELOPMENT AND THERAPY, 2014,8, 1515-1525.
21. Jia, Fei; Hong, Juan; Sun, Ping-Hua; Chen, Jian-Xin; Chen, Wei-Min. Facile Synthesis of the Neuraminidase Inhibitor Peramivir , SYNTHETIC COMMUNICATIONS, 2013,43(19):2641-2647.
荣誉称号与奖励： 1. 叶文才，吴晓明，王广基，张冬梅，汪 豪，范春林，陈卫民，周芳，徐进宜，张晓琦，毕 毅，张经纬，孙建国，王英，赵守训。中药白头翁活性分成的系统研究与应用，广东省科技进步一等奖，2014。 2. 陈卫民，余传林，徐继红，徐伟，刘叔文，金大地，吴曙光。新药依替膦酸二钠的研究，军队科技进步三等奖，1998。 3. 吴曙光，余传林，陈卫民，徐继红，刘叔文，徐伟，苗惠珠，付湘龙，陈望忠。抗高血压新药卡维地洛的研制及临床应用，军队科技进步二等奖，1999。 4. 吴曙光，陈卫民，余传林，徐继红，刘叔文。新型降血压药物的基础与临床研究，广东省科技进步三等奖，1999。 主要社会兼职： 1. 广东省药学会药物化学专业委员会委员 2. Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Chemical Biology & Drug Design，有机化学等国际国内学术期刊稿件评阅人。2015年被European Journal of Medicinal Chemistry授予Outstanding Reviewer; 2016年Bioorganic & Medicinal Chemistry Letters授予Recognized Reviewer。
联系方式：
Tel: 020-85224497
Email: twmchen@jnu.edu.cn
