首页 > 师资队伍 > 副教授副教授
张在军
发布时间:2015-09-21

张在军,神经药理学博士,副研究员,硕士生导师。主要从事神经药理学教学、科研工作,研究方向为治疗神经退行性疾病 (帕金森病、脑中风、阿尔茨海默病等) 的多功能神经保护活性化合物的研究与开发。主持包括国家自然科学基金,广东省自然科学基金和广州市科技计划等各类项目10余项。 已发表论文100余篇,被SCI收录论文70余篇,其中在Free Radical Biology and Medicine, British Journal of Pharmacy, Journal of Neurochemisty, CNS Neuroscience & Therapy等国际SCI期刊发表第一或通讯作者论文30余篇,最高单篇论文他引达100多次。参与申请发明专利20余项,获授权10余项。

 

主要研究方向

神经药理学

 

主要学术奖励:

中国博士后基金-香港学者学会香江学者奖(2013年)

 

主持的科研项目

1. 2015广东省自然科学基金自由申请项目 (2015A030313317)

2. 2013国家自然科学基金青年基金项目 (81303251)

3. 2013年度广州市科技计划科学研究专项  (2014J4100097)

4. 2013广东省医学科研基金 (A2013353)

5. 2012澳门大学横向合作研究项目 (40113010)

 

近两年发表的代表性论文 (第一或通讯作者, 10)

1.       Tetramethylpyrazine nitrone activates AKT/CREB through increasing BDNF expression to promote post-ischemic neuroregeneration and recovery of neurological functions in rats. Br J Pharmacol. 2017 Nov 21. doi: 10.1111/bph.14102. [Epub ahead of print]

2.         Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B. Neuropharmacology. 2017 Nov;126:12-24. doi: 10.1016/j.neuropharm.2017.08.014. 

3.       A novel Danshensu/tetramethylpyrazine derivative induces vasorelaxation on rat aorta and exerts cardioprotection in dogs. Eur J Pharmacol. 2017 Oct 21;818:158-166. doi: 10.1016/j.ejphar.2017.10.034. [Epub ahead of print]

4.       Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. 2017 May 15;118:137-147.

5.       Tetramethylpyrazine nitrone protects retinal ganglion cells against N-methyl-D-aspartate-induced excitotoxicity. Journal of Neurochemistry. 2017 May;141(3):373-386.

6.       Tetramethylpyrazine nitrone, a multifunctional neuroprotective agent for ischemic stroke therapy. Sci Rep. 2016 Nov 14;6:37148. doi: 10.1038/srep37148.

7.       Tetramethylpyrazine nitrone improves neurobehavioral functions and confers neuroprotection on rats with traumatic brain injury. Neurochemical Research 2016 Nov;41(11):2948-2957.

8.       Discovery, Synthesis, and Functional Characterization of a Novel Neuroprotective Natural Product from the Fruit of Alpinia oxyphylla for use in Parkinson’s Disease Through LC/MS–Based Multivariate Data Analysis–Guided Fractionation. Journal of Proteome Research 2016, 5;15(8):2595-606.

9.       Multifunction of Chrysin in Parkinson’s Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. Journal of Agricultural and Food Chemistry 2016, 6;64(26):5324-33.

10.   No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson’s disease mice. Neural Regen Res 2016, 11(8):1339-1346. 

 

 

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