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朱建华
发布时间:2014-07-18

 

朱建华,女,博士,副教授,博士研究生导师,广东省自然科学杰出青年基金获得者,广东省特支计划科技创新青年拔尖人才和广州市珠江科技新星计划入选者。承担国家重大科技专项、国家自然科学基金、广东省杰出青年科学基金、广东省特支计划科技创新拔尖人才等课题20余项;发表论文40余篇(含SCI论文25篇);参编著作3部;申请专利7项。中国中药协会人参属药用植物研究发展专业委员会委员, 教育部学位与研究生教育发展中心通讯评议专家,担任Scientific Reports等杂志审稿人。

 

主要研究方向:1)天然药物活性成分的生物合成和生物转化;

2)多肽蛋白/多糖活性成分研究;

3)创新药物的研究和开发。

3年主持的科研项目:

(1)   国家自然科学基金:81673571,基于长春花干细胞培养体系的萜类吲哚生物碱生物合成及ORCA3的调控机制研究,2017/01-2020/1258万元, 在研。

(2)   广东省杰出青年科学基金:2016A030306009,基于长春花干细胞培养体系的萜类吲哚生物碱生物合成及ORCA3的调控机制研究,2016/06/01-2020/06/01

(3)   广东省特支计划科技创新青年拔尖人才项目:2016TQ03R60630万元。

(4)   广东省自然科学基金自由申报项目:2014A030313385,青蒿素生物合成终端反应分子机理及高产青蒿素黄花蒿细胞培养体系的研究, 2015-201810万元,在研。

(5)广州市科技计划项目广州市珠江科技新星专项:2014J2200004,基于银杏干细胞培养体系的海松二烯生物合成银杏内酯及其代谢调控研究,2014-201730万元,在研。

近三年内发表的代表性论文(或论著)

已发表研究论文43篇,其中SCI收录论文28篇。近3年代表性论著如下:

1.Purification and structural characterization of a novel anti-tumor protein from Arca inflate. International Journal of Biological Macromolecules, 2017, DOI: http://dx.doi.org/doi:10.1016/j.ijbiomac.2017.07.001.

2.Antibacterial Activity of AI-Hemocidin 2, a Novel N-Terminal Peptide of Hemoglobin Purified from Arca inflate. Marine Drugs. 2017, doi:10.3390/md15070205.

3.Structural characterization and biological activities of a novel polysaccharide from cultured Cordyceps militaris and its sulfated derivative. Journal of Agricultural and Food Chemistry, 2015, 633464-3471.

4.Isolation, characterization and bioactivities of a new polysaccharide from Annona squamosa and its sulfated derivative. Carbohydrate Polymers, 2016, 152: 287-296.

5.Effects of β-cyclodextrin and methyl jasmonate on the production of vindoline,  catharanthine, and ajmalicine in Catharanthus roseus cambial meristematic cell cultures. Applied Microbiology and Biotechnology, 2015, 99: 7035-7045.

6.Purification and partial characterization of a new antitumor protein from Tegillarca granosa. Marine Drugs. 2015, 13: 1466-1480.

7.Purification and characterization of an antibacterial and anti-inflammatory polypeptide from Arca subcrenata. International Journal of Biological Macromolecules. 2017, 96:177-184.

8.A novel terpenoid indole alkaloid derived from catharanthine via biotransformation by suspension- cultured cells of Catharanthus roseus. Biotechnology Letters. 2015, 37: 2481-2487.

9.Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation. World Journal of Microbiology & Biotechnology. 2014, 30:175-180.

10.Stereo and region-selective biosynthesis of two new dihydroartemisinic acid glycosides by suspension-cultured cells of Artemisia annua. Pharmacognosy Magazine. 2014, 10: S110-S114.

11.Region-selective biosynthesis of artemisinic acid glycosides by crown galls of Panax quinquefolium and their in vitro antitumor activities. Pharmacognosy Magazine, 2015, 1143: 518-523.

12.Effect of enzyme inhibitors on terpene trilactones biosynthesisand gene expression profiling in Ginkgo biloba cultured cells. Natural Product Communications. 2015, 1012):2033-2035.

13.Artemisinic acid serves as a novel ORCA3 inducer to enhance biosynthesis of terpenoid Indole alkaloids in Catharanthus roseus cambial meristematic cells. Natural product communications, 2016, 116:715-717.

14.Inducing effect of dihydroartemisinic acid in the biosynthesis of artemisinins in cultured cells of Artemisia annua by enhancing the expression of genes. Scientific World Journal. 2014, doi: 0.1155/2014/ 293190.