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许芳
发布时间:2017-06-05

许芳,女,理学博士,副教授。

2008年获中山大学理学博士学位,20154月进入暨南大学药学院,从事教学科研工作。主要从事抗肿瘤药理学研究工作。先后承担中国博士后基金,省自然科学基金,参与多项国家科研基金项目的研究,发表多篇SCI论文,获得授权专利一项。

主要研究方向

1. 肿瘤靶向小分子研究

2. 靶向肿瘤干细胞药物药力学研究

 

代表性论文:

1. Fang Xu, Yingjie Zhu, Yuhong Lu, Zhi Yu, Jun Zhong, Yangqiu Li, and Jingxuan Pan. The Anthelmintic Pyrvinium Pamoate Blocks Wnt/β-catenin and Induces Apoptosis in Multiple Myeloma Cells. Oncology Letters. 2017, 6, Accepted.

2. Yanli Jin, Jingfeng Zhou, Fang Xu, Bei Jin, Lijing Cui, Yun Wang, Xin Du, Juan Li, Peng Li, Ruibao Ren, and Jingxuan Pan. Targeting methyltransferase PRMT5 eliminates leukemia stem cells in chronic myelogenous leukemia. J Clin Invest. 2016; 126(10):3961-3980. PMID: 27643437.

3. Fang Xu, Hong Chen, Xuelan He, Jingyi Xu, Bingbing Xu, Biyun Huang, Xue Liang, Mu Yuan. Identification of two novel agonists as α1-AR sub-selective agonists using a high-throughput screening model. Molecules. 2014, 19, 12699-12709.

4. Fang Xu, Xianping Shi, Shichang Li, Jieshun Cui, Zhongzheng Lu, Yongcheng Lin, Jiyan Pang, Jingxuan Pan, Design, Synthesis, and Biological Evaluation of Novel Water-Soluble Triptolide Derivatives: Antineoplastic Activity against Imatinib-resistant CML Cells Bearing T315I Mutant Bcr-Abl. Bioorganic & Medicinal Chemistry, 2010; 18:1806–1815. PMID: 20149665.

5. Fang Xu, Jiyan Pang, Bingtai Lu, Jiajun Wang, Yi Zhang, Zhigang She, L. L. P. Vrijmoed and E. B. Gareth Jones, Yongcheng Lin, Two metabolites with DNA-binding affinity from the Mangrove Fungus Xylaria sp. (#2508) from the South China Sea Coast. Chinese Journal of Chemistry, 2009, 27(2), 365-368.

6. Fang Xu, Yi Zhang, Jiajun WangCaihuan HuangZhigang She, L. L. P. Vrijmoed and E. B. Gareth Jones, Yongcheng Lin, Benzofuran Derivatives from the mangrove fungus xylaria sp. 2508. Journal of Natural Products, 2008, 71, 1251-1253.  

7. Hong Chen, Fang Xu, Bingbing Xu, Zhuo Zhu, Mu Yuan*. Design, Synthesis and Biological Evaluation of Novel Arylpiperazine Derivatives on Human Prostate Cancer Cell Lines. Bioorganic & Medicinal Chemistry Letter. 2015, 25(2), 285-287.