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任小梅
发布时间:2017-06-02

任小梅博士,暨南大学药学院副研究员

研究方向

药物研发领域中生物学活性筛选,药效学评价和作用机制的研究。重点围绕肝癌、胰腺癌和肺癌等重大临床需求,针对潜在的分子靶标(受体酪氨酸激酶Bcr-Abl, EGFR, DDR, FGFR,转录因子STAT3和ERR等),进行创新药物候选分子的发现研究。

学习经历

2013/7  中山大学医院院病理生理学博士学位。

1998/7  中国药科大学药理学专业硕士学位

1995/7  中国药科大学,药理学专业,学士学位;

工作经历

2016-     暨南大学药学院副研究员

2007-2016 广州生物医药与健康研究院助理研究员到副研究员;

2002-2007 密歇根大学医学院分子与行为神经科学研究Research Associate

1998-2001 中科院上海生理所助理研究员;

奖励

2016年,广州市科技进步一等奖和广东省科技进步二等奖。

代表性成果

近年来通过团队协作,成功研发了:1)可克服慢粒白血病人(CML)临床耐药的新一代Bcr-AblT315I突变体抑制剂(专利权转让至广州顺健,2016年已开始I期临床)2)全新的可克服非小细胞肺癌(NSCLC)对Gefitinib等临床获得性耐药的特异性EGFRT790M突变抑制剂(专利权转让至南京奥赛康药业,已申报国家CFDA临床研究);3)世界首个选择性DDR1抑制剂作为新型治疗胰腺癌药物候选物;4)可有效治疗急性髓型白血病(AML)耐药的新型Axl-Flt3双重抑制剂;5)首次发现了传统氯硝柳胺作为全新的STAT3抑制剂等。已与美国德州大学西南医学中心Rolf Brekken教授(胰腺癌药物DDR1抑制剂)和新西兰奥克兰大学(肝癌和肺癌药物等)建立紧密合作关系。近年来,发表SCI论文近30余篇,申请专利10余项。

代表性论文

1. Li Tan, Zhang Zhang, Donglin Gao, Jinfeng Luo, Zhengchao Tu, Zhengqiu Li, Lijie Peng, Xiaomei Ren*, Ke Ding*.  4-Oxo-1, 4-Dihydroquinoline-3-Carboxamide Derivatives as New Axl Kinase Inhibitors. J Med Chem. 2016 Jul 5. [共同通讯作者]

2. Zhen Wang, Huan BianSergio G. Bartual, Wenting Du, Jinfeng Luo, Hu ZhaoShasha Zhang, Cheng Mo, Yang Zhou, Yong Xu, Zhengchao Tu, Xiaomei Ren, Xiaoyun Lu, Rolf A. Brekken, Libo YaoAlex N. Bullock, Jin Su, Ke Ding. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. J Med Chem. 2016; 59(12):5911-6.

3. Zhang Zhang*, Xiaomei Ren* , Xiaoyun Lu, Deping Wang, Xianjing Hua, Yi Zheng, Liyan Song, Hongwen Pang, Rongmin Yu, Ke Ding.  GZD856, a novel potent PDGFRα/β inhibitor, suppresses the growth and migration of lung cancer cells in vitro and in vivo. Cancer Lett. 2016 ;375(1):172-8. [Impact Factor: 5.992共同第一作者]

4. Chiara Ambrogio, Gonzalo Gómez-López, Mattia Falcone, August Vidal, Ernest Nadal,Nicola Crosetto, Rafael B Blasco, Pablo J Fernández-Marcos, Montserrat Sánchez-Céspedes, Xiaomei Ren, Zhen Wang, Ke Ding, Manuel Hidalgo, Manuel Serrano, Alberto Villanueva, David Santamaría, Mariano Barbacid. Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. Nat Med. 2016; 22(3):270-7. [Impact Factor:27.363]

5. Shilin Xu, Liufeng Mao, Ping Ding, Xiaoxi Zhuang, Yang Zhou, Lei Yu, Yingxue Liu, Tao Nie,Tingting Xu, Yong Xu, Jinsong Liu, Jeff Smaill, Xiaomei Ren, Donghai Wu, Ke Ding. 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor c and promote the browning of white adipose. J. Med. Chem. 2015, 233751–3760. (IF:5.614)

6. Yingjun Li, Huimin Cheng, Zhang Zhang, Xiaoxi Zhuang, Jinfeng Luo, Huoyou Long, Yang Zhou, Yong Xu, Rana Taghipouran, Dan Li, Adam Patterson, Jeff Smaill, Zhengchao Tu, Donghai Wu, Xiaomei Ren,* and Ke Ding*. N (3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors. ACS Med. Chem. Lett. 2015, 6, 543−547 (共同通讯作者,IF3.073)

7. Yingying Shen*, Xiaomei Ren*, Ke Ding, Zhang Zhang, Deping Wang and Jingxuan Pan.Antitumor activity of S116836, a novel tyrosine kinase inhibitor, against imatinib-resistant FIP1L1-PDGFRα-expressing cells. Oncotarget, 2014;5(21):10407-20.(共同第一作者,IF6.627

8. Xiaomei Ren, Xiaofen Pan, Zhang Zhang, Deping Wang, Xiaoyun Lu, Yupeng Li, Donghai Wen, Huoyou Long, Jinfeng Luo, Yubing Feng, Xiaoxi Zhuang, Fengxiang Zhang, Jianqi Liu, Fang Leng, Xingfen Lang, Yang Bai, Miaoqin She, Zhengchao Tu, Jingxuan PanKe Ding. Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib. J Med Chem. (2013), 56(3):879-94.

9. Shilin Xu, Xiaoxi Zhuang, Xiaofen Pan, Zhang Zhang, Lei Duan, Yingxue Liu, Lianwen Zhang, Xiaomei Ren*, and Ke Ding*. 1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor α. J Med Chem (2013), 56(11):4631-40. IF: 5.614, 共同通讯作者)

10. Tianfeng Xu, Lianwen Zhang, Shilin Xu, Chao-Yie Yang, Jinfeng Luo, Fang Ding, Xiaoyun Lu, Yingxue Liu, Zhengchao Tu, Shiliang Li, Duanqing Pei, Qian Cai, Honglin Li, Xiaomei Ren, Shaomeng Wang, Ke Ding.  Pyrimido[4,5-d]pyrimidin-4(1H)-one derivatives as selective inhibitors of EGFR threonine790 to methionine790 (T790M) mutants. Angew Chem Int Ed Eng (2013) , 52(32):8387-90. IF: 11.261

11. Mingshan Gao, Lei Duan, Jinfeng Luo, Lianwen Zhang, Xiaoyun Lu, Yan Zhang, Zhang Zhang, Zhengchao Tu, Yong Xu, Xiaomei Ren, Ke Ding. Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem ( 2013), 56(8):3281-95.

12. Yupeng Li, Mengjie Shen, Zhang Zhang, Jinfeng Luo, Xiaofen Pan, Xiaoyun Lu, Huoyou Long, Donghai Wen, Fengxiang Zhang, Fang Leng, Yingjun Li, Zhengchao Tu, Xiaomei Ren, Ke Ding. Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)isoleucine(315) mutant. J Med Chem (2012), 55(22):10033-46.

13. Jin Zhang, Jing Zhou, Xiaomei Ren, Yanyan Diao, Honglin Li, Hualiang Jiang, Ke Ding, Duanqing Pei A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton. Invest New Drugs.(2012), 30(2):490-507. (IF:3.281)

14. Lijie Peng, Xuefei Gao, Lei Duan, Xiaomei Ren, Donghai Wu, and Ke Ding. Identification of pyrido[1,2-α]pyrimidine-4-ones as new molecules improving the transcriptional functions of estrogen-related receptor α. J Med Chem (2011), 54(21):7729-33.

15. Xiaomei Ren, Lei Duan, Qiang He, Zhang Zhang, Yi Zhou, Donghai Wu, Jingxuan Pan, Duanqing Pei, Ke Ding. Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway. ACS Medicinal Chemistry Letters (2010), 1(9), 454-459. (IF:3.355)

16. Xiaomei Ren, Michael D. Uhler. Microarray transfection analysis of conserved genomic sequences from three immediate early genes. Genomics (2009), 93(2):159-68. IF:2.896

17. Tanya M. Redmond, Xiaomei Ren, Ginger Kubish, Stephen Atkins, Sean Low and Michael D. Uhler. Microarray transfection analysis of transcriptional regulation by cAMP-dependent protein kinase. Mol Cell Proteomics (2004) Aug;3(8):770-9. IF:5.912

18. Jianying Zhou, Zhongfeng Wang, Xiaomei Ren, Mianzhi Tang, Yuliang Shi. Antagonism of botulinum toxin type A-induced cleavage of SNAP-25 in rat cerebral synaptosome by toosendanin. FEBS Lett (2003), 555(2), 375-9. IF:3.37

19. Zhenjia Zhu, Zhiyu Qian ,Lihua Lu, Xiaomei Ren.  Studies of geniposide and crocins from Cape Jasmine (Gardenia jasminoides) on the biliary secretion in rat. Zhongcaoyao (1999), 30(11), 841-843.