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张兴旺
发布时间:2017-05-31

张兴旺,男, 博士,副教授。皖亳州市人,20057月毕业于安徽中医药大学,药物制剂专业;20087月毕业于河南中医药大学,药剂学专业;20137月毕业于复旦大学,药剂学专业,获理学博士学位,毕业论文获得上海市研究生优秀论文成果奖(优博)。20088– 20109月,先后任职于上海医药(集团)中央研究院和和记黄埔(上海)医药有限公司,从事制剂的研究与开发工作。20138– 20158月在暨南大学中药学博士后流动站工作。20159月至今就职于暨南大学药学院,任副教授。

主要从事纳米给药系统、药物制剂新技术和中西药物制剂开发方面的工作。先后主持了中国博士后科学基金、国家自然科学基金青年项目和面上项目。在药学和纳米医学领域发表SCI论文30余篇。担任ACS Appl Mater Interfaces, Int J Pharm, J Drug Targeting, Drug Deliv, AAPS PharmaSciTech等多个SCI期刊的同行评议人。申请发明专利4项,授权1项。参编教材1部。

 

主要研究方向

1. 纳米药物传递系统

2. 口服给药

3. 中西药物制剂开发与评价

代表性论文

1. Wenji Deng, Qian Xie, Huan Wang, Zhiguo Ma, Boajian Wu*, Xingwang Zhang*. Selenium nanoparticles as versatile carriers for oral delivery of insulin: insight into the synergic antidiabetic effect and mechanism. Nanomedicine: Nanotechnology, Biology and Medicine. 2017, doi: 10.1016/j.nano.2017.05.002.

2. Zhongjian Chen, Tianpeng Zhang, Baojian Wu, Xingwang Zhang*. Insights into the therapeutic potential of hypoxia-inducible factor-1α; small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes. International Journal of Nanomedicine. 2016, 11:991-1002.

3. Yanghuan Ye, Tianpeng Zhang, Wan Li, Hua Sun, Danyi Lu, Baojian Wu*, Xingwang Zhang*. Glucose-based mesoporous carbon nanospheres as functional carriers for oral delivery of amphiphobic raloxifene: insights into the bioavailability enhancement and lymphatic transport. Pharmaceutical Research. 2016, 33(3): 792-803.

4. Xingwang Zhang, Tianpeng Zhang, Yali Lan, Baojina Wu* and Zhihai Shi*. Nanosuspensions containing oridonin/HP-β-cyclodextrin inclusion complexes for oral bioavailability enhancement via improved dissolution and permeability. AAPS PharmSciTech. 2016, 17(2):400-408.

5. Xingwang Zhang, Dong Dong, Huailing Wang, Zhiguo Ma, Baojian Wu*. Stable knockdown of efflux transporters leads to reduced glucuronidation in UGT1A1-overexpressing HeLa cells: the evidence for glucuronidation-transport interplay. Molecular Pharmaceutics. 2015, 12(4): 1268-78.

6. Wan Li, Tianpeng Zhang, Yanghuan Ye, Xingwang Zhang*, Baojian Wu*. Enhanced bioavailability of tripterine through lipid nanoparticles using broccoli-derived lipids as a new carrier material. International Journal of Pharmaceutics. 2015, 495(2): 948-955.

7. Xingwang Zhang, Tianpeng Zhang, Yanghuan Ye, Huaqing Chen, Hua Sun, Xiaotong Zhou, Zhiguo Ma, Baojian Wu*. Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect. European Journal of Pharmaceutics and Biopharmaceutics. 2015, 94:30-41.

8. Xiaotong Zhou, Xingwang Zhang*, Yanghuan Ye, Tianpeng Zhang, Huan Wang, Zhiguo Ma, and Baojian Wu*. Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption. International Journal of Pharmaceutics. 2015, 479(2): 391-398.

9. Yanghuan Ye, Xingwang Zhang*, Tianpeng Zhang, Huan Wang, and Baojian Wu*. Design and evaluation of injectable niclosamide nanocrystals prepared by wet media milling technique. Drug Development and Industrial Pharmacy. 2015, 41(9):1416-1424.

10. Xingwang Zhang, Yong Zhang, Tianpeng Zhang, Jianping Zhang*, and Baojian Wu*. Significantly enhanced bioavailability of niclosamide through submicron lipid emulsions with or without PEG-lipid: a comparative study. Journal of Microencapsulation. 2015, 32(5):496-502.

11. Xingwang Zhang and Baojian Wu*. Submicron lipid emulsions-a versatile platform for drug delivery. Current Drug Metabolism. 2015, 16(3):211-220.

12. Xingwang Zhang, Jianping Qi, Yi Lu, Xiaoyang Li, Wei He, Wei Wu*. Biotinylated liposomes as potential carriers for oral delivery of insulin. Nanomedicine: Nanotechnology, Biology and medicine. 2014, 10(1): 167-176.

13. Xingwang Zhang and Wei Wu*. Ligand-mediated active targeting for enhanced oral absorption. Drug Discovery Today. 2014, 19(7): 898-904.

14. Xingwang Zhang, Tianpeng Zhang, Xiaotong Zhou, Hongming Liu, Hua Sun, Zhiguo Ma, Baojian Wu*. Enhancement of oral bioavailability of tripterine through lipid nanospheres: preparation, characterization, and absorption evaluation. Journal of Pharmaceutical Sciences. 2014, 103(6): 1711-1719.

15. Xingwang Zhang, Jianping Qi*, Yi Lu, Xiongwei Hu, Wei He, and Wei Wu. Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking, and cytotoxicity. Nanoscale Research Letters. 2014, 9(1): 185-194.

16. Xingwang Zhang, Huan Wang, Tianpeng Zhang, Xiaotong Zhou, Baojian Wu*. Exploring the potential of self-assembled mixed micelles in enhancing the stability and oral bioavailability of an acid-labile drug. European Journal of Pharmaceutical Sciences. 2014, 62: 301-308.

17. Xingwang Zhang, Huan Wang, Zhiguo Ma, and Baojian Wu*. Effects of pharmaceutical PEGylation on drug metabolism and its clinical concerns. Expert Opinion on Drug Metabolism & Toxicology. 2014, 10(12):1691-1702.

18. Xingwang Zhang, Guijiang Chen, Tianpeng Zhang, Zhiguo Ma, and Baojian Wu*. Effects of PEGylated lipid nanoparticles on the oral absorption of one BCS II drug: a mechanistic investigation. International Journal of Nanomedicine. 2014, 26(9):5503-5514.