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王磊
发布时间:2017-03-27

王磊,男,理学博士,研究员,博士生导师,获得广东省杰出青年基金,入选广东特支计划百千万青年拔尖人才、广州市珠江科技新星人才计划。

先后承担了国家重点研发计划(课题负责人)、国家自然科学基金面上项目、广东省自然科学杰出青年基金、国家自然科学基金青年项目、中国博士后科学基金特别资助、中国博士后科学基金、广东省自然科学基金等科研项目10余项;已发表研究论文100余篇,其中SCI收录论文71篇(第一作者或通讯作者40篇),包括Chemical Science, Organic Letters, Journal of Natural Products, Tetrahedron等国际权威期刊;申请发明专利8项。

 

代表性论文:

1.        Cheng Min-Jing, Cao Jia-Qing, Yang Xin-Yi, Zhong Li-Ping, Hu Li-Jun, Lu Xi, Hou Bao-Long, Hu Ya-Jian, Wang Ying, You Xue-Fu, Wang Lei*, Ye Wen-Cai* and Li Chuang-Chuang*. Catalytic Asymmetric Total Syntheses of Myrtucommuacetalone, Myrtucommuacetalone B and Callistrilones A, C, D, E. Chemical Science, 2018, DOI: 10.1039/C7SC04672C. (IF:8.668)

2.        Zhang Wei, Xu Wei, Wang Gui-Yang, Gong Xue-Ying, Li Ni-Ping, Wang Lei* and Ye Wen-Cai*. Gelsekoumidines A and B: Two Pairs of Atropisomeric Bisindole Alkaloids from the Roots of Gelsemium elegans. Organic letters, 2017, 19(19): 5194-5197.(IF 6.579)

3.        Liu Chao, Ang Song, Huang Xiao-Jun, TianHai-Yan, Deng Yuan-Yuan, Zhang Dong-Mei, Wang Ying*, Ye Wen-Cai*, Wang Lei*. Meroterpenoids with New Skeletons from Myrtuscommunis and Structure Revision of Myrtucommulone K. Organic Letters, 2016, 18(16): 4004-4007.(IF 6.732)

4.        Cao Jia-Qing, Huang Xiao-Jun, Li Yu-Ting, Wang Ying, Wang Lei*, Jiang Ren-Wang*, Ye Wen-Cai*. Callistrilones A and B, Triketone−Phloroglucinol− MonoterpeneHybrids with a New Skeleton from Callistemon rigidus. Organic Letters, 2016, 18(1): 120-123.(IF 6.732)

5.        Wang Cun-Qin, Wang Lei*, Fan Chun-Lin, Zhang Dong-Mei, Huang Xiao-Jun, Jiang Ren-Wang, Bai Liang-Liang, Shi Jun-Min, Wang Ying*, Ye Wen-Cai*. Ilelicacids A and B, two unusual triterpenes with a seven-membered ring from Ilex latifolia. Organic Letters, 2012, 14(16): 4102-4105.(IF 6.732)

6.        Hu Bin, Wang Lei(co-first author), Yao Zhong-Ping*, Ye Wen-Cai*. In vivo and real-time monitoring of secondary metabolites of living organisms by Mass spectrometry. Scientific Reports, 2013, 3: 2104. (IF 5.078)

7.        Tang Ben-Qin, Wang Wen-Jing, Huang Xiao-Jun, Li Guo-Qiang, Wang Lei,* Jiang Ren-Wang, Yang Ting-Ting, Shi Lei, Zhang Xiao-Qi,* Ye Wen-Cai*. Iboga-type alkaloids from Ervatamiaofficinalis. Journal of Natural Products, 2014, 77 (8): 1839-1846 (IF 3.947)

8.        Zhang Wei, Huang Xiao-Jun, Zhang Sheng-Yuan, Zhang Dong-Mei, Jiang Ren-Wang, Hu Jian-Yang, Zhang Xiao-Qi, Wang Lei*, Ye Wen-Cai*. Geleganidines A−C, Unusual Monoterpenoid Indole Alkaloids fromGelsemiumelegans.Journal of Natural Products, 2015, 78, 2036-2044 (IF 3.798).

9.        Tian Hai-Yan, Ruan Li-Jun, Yu Tong, Zheng Qing-Fei, Chen Nan-Hao, Wu Rui-Bo, Zhang Xiao-Qi, Wang Lei*, Jiang Ren-Wang* and Ye Wen-Cai*. Bufospirostenin A and Bufogargarizin C, Steroids with Rearranged Skeletons from the Toad Bufo bufo gargarizans. Journal of Natural Products, 2017, 80(4): 1182-1186. (IF 3.281)

10.    Cao Jia-Qing, Tian Hai-Yan , Li Man-Mei, Zhang Wei, Wang Ying , Wang Lei*, Ye Wen-Cai*. Rearranged Phloroglucinol-Monoterpenoid Adducts from Callistemon rigidus. Journal of Natural Products, 2017, 10.1021/acs.jnatprod.7b00606. (IF 3.281)

11.    Zhou Shi-Wen, Zheng Qing-Fei, Huang Xiu-Yong, Wang Yong, Luo Si-Fan, Jiang Ren-Wang, Wang Lei*, Ye Wen-Cai* and Tian Hai-Yan*. Isolation and identification of L/D-lactate-conjugated bufadienolides from toad eggs revealing lactate racemization in amphibians. Organic & Biomolecular Chemistry, 2017, 15: 5609-5615. (IF 3.564)

12.    Huang Xiao-Jun, Wang Lei(co-first author), Shao Meng, Jiang Ren-Wang, Yao Xin-Sheng, Li Yao-Lan, Yin Zhi-Qi, Wang Ying*, Ye Wen-Cai*. Oleonin, the first secoiridoid with 1α-configuration from Ligustrumlucidum. RSC Advances, 2013, 3: 16300-16303. (IF 3.708)

13.    Wang Wen-Jing , Wang Lei(co-first author), Liu Zhong, Jiang Ren-Wang, Liu Zhi-Wen, Li Man-Mei, Zhang Qing-Wen, Dai Yi, Li Yao-Lan, Zhang Xiao-Qi*, Ye Wen-Cai*. Antiviral benzofurans from Eupatorium chinense. Phytochemistry, 2016,122: 238-245. (IF 3.205)

14.    Chen Ming, Chen Li- Feng, Li Man-Mei, Li Ni-Ping, Cao Jia-Qing ,Wang Ying, Li Yao-Lan, Wang Lei* and Ye Wen-Cai*. Myrtucomvalones A–C, three unusual triketone–sesquiterpene adducts from the leaves of Myrtus communis ‘Variegata’. RSC Advances, 2017, 7(37): 22735-22740. (IF 3.289)

15.    Ouyang Sheng, Wang Lei(co-first author), Zhang Qing-Wen, Wang Guo-Cai, Wang Ying, Huang Xiao-Jun, Zhang Xiao-Qi, Jiang Ren-Wang, Yao Xin-Sheng, Che Chun-Tao, Ye Wen-Cai*. Six new monoterpenoid indole alkaloids from the aerial part of Gelsemiumelegans. Tetrahedron, 2011, 67(26): 4807-4813.(IF 3.030)

 

代表性科研课题:

(1)   国家自然科学基金面上项目:石蒜碱类化合物抑制流感病毒RNP 出核转运的作用机制和构效关系研究(项目编号:8127339120131~201612月),主持。

(2)   国家自然科学基金面上项目钩吻生物碱抑制呼吸中枢的结构-毒性关系和毒理机制研究(项目编号:8157330720161~201912月),主持。

(3)   广东省自然科学杰出青年基金基于蛋白激酶B研究钩吻生物碱抗肝癌的构效关系和作用机制(项目编号:2015A03030602220156~20196月),主持。

(4)   国家自然科学基金青年科学基金项目:石蒜碱类化合物抗流感病毒的作用机制和构效关系研究(项目编号:8100137520111~201112月),主持。

(5)   中国博士后科学基金特别资助项目:钩吻生物碱抗肿瘤活性成分研究(项目编号:20110436920119~20123月),主持。

(6)   中国博士后科学基金项目:以TrkB为靶标研究天然去氧糖抗癫痫活性的作用机制和构效关系(项目编号:2010047094320117~20129月),主持。

(7)   广东省自然科学基金博士科研启动项目:基于靶标TrkB研究天然去氧糖抗癫痫活性的构效关系和作用机制(项目编号:10451063201005465201010~20129月),主持。

(8)   广州市珠江科技新星人才计划Lycorine抑制流感病毒的作用机制和构效关系(项目编号:201301520131~201512月),主持。

 

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