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何蓉蓉
发布时间:2016-04-06

何蓉蓉,药学专业博士,教授,博士研究生导师,暨南大学中药及天然药物研究所副所长,广东省疾病易感性及中医药研发工程技术研究中心主任。相关研究获得国家重大新药创制、国家自然科学基金、广东省自然科学基金等十余个项目的资助,获得 “国家优青”、“广东省杰青”、教育部“新世纪杰出人才”、广东省“拔尖人才”、“珠江科技新星”等人才项目。发表论文120余篇,第一/通讯作者SCI论文50余篇,包括Free Radical Bio MedMol NeurobiolDis Mod MechSci RepMol Nutr Food Res等。研究成果获得中国专利奖、广东省科技进步二等奖、教育部科技进步二等奖、中华医学会三等奖。

 

主要研究方向:

1.药理学(神经-免疫药理学、抗应激药理学)

2.中医药学(情志致病理论研究、中药药理)

 

 

教育研究经历:

2000/10-2004/07:沈阳药科大学,中药学院,中药学/学士

2004/09-2009/06:沈阳药科大学,中药学院,药学/博士

2009/07 -2011/01:暨南大学,药学院,讲师

2011/10-2015/09:暨南大学,药学院,副教授

2013/01-2014/01:匹兹堡大学,自由基与抗氧化研究中心,访问学者

2015/10-今:暨南大学,药学院,教授/博士生导师

 

主要学术奖励:

1.        何蓉蓉、曹会娟、李怡芳、栗原博等. 九节茶提取物在降低流感病毒易感性上的应用,中国专利专利奖 2015年)。

2.        姚新生(导师), 何蓉蓉, 宝丽, . 广东凉茶“泻火”作用机理研究与应用推广,广东省科学技术进步二等奖,2010

3.        姚新生(导师), 何蓉蓉, 宝丽, . 广东凉茶“泻火”作用科学内涵与质量标准研究,教育部科学技术进步二等奖,2011

4.        姚新生(导师), 何蓉蓉, 宝丽, .广东凉茶“泻火”作用机理与质量标准的研究及应用推广,中华医学科技奖三等奖,2011

5.        何蓉蓉,中国药学会--赛诺菲青年生物药物奖,2012

 

获人才项目:

国家级人才项目:国家自然科学基金优秀青年基金

教育部人才项目:教育部新世纪优秀人才支持计划

省级人才项目:广东省自然科学杰出青年

省级人才项目:广东省特支计划”-科技创新拔尖人才

市级人才项目:广州市江科技新星计划。

 

承担的其他科研项目:

1.  国家自然科学基金面上项目

2.  国家自然科学基金青年基金

3.  国家科技重大专项-“重大新药创制专项

4.  广东省自然科学基金

5.  国家重点实验室开放基金

6.  省部产学研引导项目

7.  广东省中医药局科研课题

8.  暨南大学科研培育与创新基金面上项目

9.  白兰氏健康研究中心国际合作项目

 

近三年发表的主要英文论文(按照出版时间排序,*为通讯作者)

【1】        Chen H, Jie C, Tang LP, Meng H, Li XB, Li YB, Chen LX, Yan C, Kurihara H, Li YF, He RR*. New insights into the effects and mechanism of a classic traditional Chinese medicinal formula on influenza prevention. Phytomedicine. 2017 Apr 15;27:52-62.

【2】        Li YF, Chang YQ, Deng J, Li WX, Jian J, Gao JS, Wan X, Gao H, Kurihara H, Sun PH, He RR*. Prediction and evaluation of the lipase inhibitory activities of tea polyphenols with 3D-QSAR models. Sci Rep. 2016 Oct 3;6:34387

【3】        Yang J, Wu Y, Shen Y, Zhou C, Li YF, He RR*, Liu M. Enhanced Therapeutic Efficacy of Doxorubicin for Breast Cancer Using Chitosan Oligosaccharide-Modified Halloysite Nanotubes. ACS Appl Mater Interfaces. 2016 Oct 12;8(40):26578-26590.

【4】        Li YF, Ouyang SH, Chang YQ, Wang TM, Li WX, Tian HY, Cao H, Kurihara H, He RR*. A comparative analysis of chemical compositions in Camellia sinensis var. puanensis Kurihara, a novel Chinese tea, by HPLC and UFLC-Q-TOF-MS/MS. Food Chem. 2017 Feb 1;216:282-8.

【5】        Tan RR, Li YF, Zhang SJ, Huang WS, Tsoi B, Hu D, Wan X, Yang X, Wang Q, Kurihara H, He RR*.  2016. Abnormal O-GlcNAcylation of Pax3 Occurring from Hyperglycemia-Induced Neural Tube Defects Is Ameliorated by Carnosine But Not Folic Acid in Chicken Embryos. Mol Neurobiol Mol Neurobiol. 2017 Jan;54(1):281-294.

【6】        Duan WJ, Li YF, Liu FL, Deng J, Wu YP, Tsoi B, Chen JL, Wang Q, Cai SH, Kuirahara H, He RR*. 2016. A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages. Free Radical Bio Med. 95:230-242

【7】        Zhang SJ, Li YF, Tan RR, Tsoi B, Huang WS, Huang YH, Tang XL, Hu D, Yao N, Yang X, Kurihara H, Wang Q, He RR*. 2016. A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo. Dis Model Mech 9(2):177-86.

【8】        Wu YH, Chen GD, He RR*, Wang CX, Hu D, Wang GQ, Guo LD, Yao XS, Gao H. 2015. Pericolactines A-C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton. Sci Rep. 5:17082.

【9】        Tsoi B, Yi RN, Cao LF, Li SB, Tan RR, Chen M, Li XX, Wang C, Li YF, Kurihara H, He RR*. 2015. Comparing antioxidant capacity of purine alkaloids: a new, efficient trio for screening and discovering potential antioxidants in vitro and in vivo. Food Chem 176: 411-9

【10】    Zhang SJ, Li YF, Wang GE, Tan RR, Tsoi B, Mao GW, Zhai YJ, Cao LF, Chen M, Kurihara H, Wang Q, He RR*. 2015. Caffeine ameliorates high energy diet-induced hepatic steatosis: sirtuin 3 acts as a bridge in the lipid metabolism pathway. Food Funct 6(8):2578-87

【11】    Tan RR, Zhang SJ, Tsoi B, Huang WS, Zhuang XJ, Chen XY, Yao N, Mao ZF, Tang LP, Wang Q, Kurihara H, Li YF, He RR*. 2015. A natural product, resveratrol, protects against high-glucose-induced developmental damage in chicken embryo. J Asian Nat Prod Res 17(5):586-94.

【12】    Li XX, Tsoi B, Li YF, Kurihara H, He RR*. 2015. Cardiolipin and Its Different Properties in Mitophagy and Apoptosis. J Histochem Cytochem63(5):301-311

【13】    Cai Y, Li YF, Tang LP, Tsoi B, Chen M, Chen H, Chen XM, Tan RR, Kurihara H, He RR*. 2015. A new mechanism of vitamin C effects on A/FM/1/47(H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int 2015: 675149

【14】    Zhao Q, Chen GD, Feng XL, Yu Y, He RR, Li XX, Huang Y, Zhou WX, Guo LD, Zheng YZ, Yao XS, Gao H. 2015. Nodulisporiviridins A-H, Bioactive Viridins from Nodulisporium sp. J Nat Prod 78(6):1221-30.

【15】    Zhou ZQ, Fan HX, He RR, Xiao J, Tsoi B, Lan KH, Kurihara H, So KF, Yao XS, Gao H. Lycibarbarspermidines A-O, New Dicaffeoylspermidine Derivatives from Wolfberry, with Activities against Alzheimer's Disease and Oxidation. J Agric Food Chem. 2016 Mar 23;64(11):2223-37.

【16】    Yao S-w, Wen X-x, Huang R-q, He RR, Ou S-y, Shen W-z, Huang C-h, Peng X-c. 2014. Protection of Feruloylated Oligosaccharides from Corn Bran against Oxidative Stress in PC 12 Cells. Journal of Agricultural and Food Chemistry 62: 668-74

【17】    Yao N, He RR, Zeng X-h, Huang XJ, Du TL, Cui JC, Hiroshi K. 2014. Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice. Chinese Journal ofIntegrative Medicine 20: 31-5

【18】    Xu M, He RR, Zhai Y-J, Abe K, Kurihara H. 2014. Effects of Carnosine on Cyclophosphamide-Induced Hematopoietic Suppression in Mice. American Journal of Chinese Medicine 42: 131-42

【19】    Wang GE, Li YF, Wu YP, Tsoi B, Zhang SJ, Cao LF, Kurihara H, He RR*. 2014. Phloridzin improves lipoprotein lipase activity in stress-loaded mice via AMPK phosphorylation. Int J Food Sci Nutr: 1-7

【20】    Tyurin VA, Balasubramanian K, Winnica D, Tyurina YY, Vikulina AS, He RR, Kapralov AA, Macphee CH, Kagan VE. 2014. Oxidatively modified phosphatidylserines on the surface of apoptotic cells are essential phagocytic 'eat-me' signals: cleavage and inhibition of phagocytosis by Lp-PLA2. Cell Death Differ 21: 825-35

【21】    Tang L-p, Xiao W, Li Y-f, Li H-b, Wang Z-z, Yao X-s, Kurihara H, He RR*. 2014. Anti-inflammatory effects of Reduning Injection on lipopolysaccharide-induced acute lung injury of rats. Chinese Journal of Integrative Medicine 20: 591-9

【22】    Tang L-P, Mao Z-F, Li X-X, Chen M, Li S-B, Tsoi B, Cao L-F, Li L, Zeng J-M, Wang Z-W, Yu G-Y, Xiao W, Li Y-F, Kurihara H, He RR*. 2014. ReDuNing, a patented Chinese medicine, reduces the susceptibility to H1N1 influenza of mice loaded with restraint stress. European Journal of Integrative Medicine6 (6): 637–645

【23】    Stoyanovsky DA, Sparvero LJ, Amoscato AA, He RR, Watkins S, Pitt BR, Bayir H, Kagan VE. 2014. Improved spatial resolution of matrix-assisted laser desorption/ionization imaging of lipids in the brain by alkylated derivatives of 2,5-dihydroxybenzoic acid. Rapid Commun Mass Spectrom 28: 403-12

【24】    Luo H, Lv X-D, Wang G-E, Li Y-F, Kurihara H, He RR*. 2014. Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillus L.) on croton oil-induced ear edema and Propionibacterium acnes plus LPS-induced liver damage in mice. International Journal of Food Sciences and Nutrition 65: 594-601

【25】    Li X, Zhao Y, Huang R, Zhu W, Zeng X, Zhao J, Feng Y, He RR*. 2014. Simultaneous quantification of 17 bioactive constituents in Sarcandra glabra by liquid chromatography-electrospray ionisation-mass spectrometry. Anal. Methods 6: 7989-95

【26】    Li SB, Li YF, Mao ZF, Hu HH, Ouyang SH, Wu YP, Tsoi B, Gong P, Kurihara H, He RR*. 2014. Differing chemical compositions of three teas may explain their different effects on acute blood pressure in spontaneously hypertensive rats. J Sci Food Agric

【27】    Li M, Wang Y, Tsoi B, Jin XJ, He RR, Yao XJ, Dai Y, Kurihara H, Yao XS. 2014. Indoleacetic acid derivatives from the seeds of Ziziphus jujuba var. spinosa. Fitoterapia 99: 48-55

【28】    Amoscato AA, Sparvero LJ, He RR, Watkins S, Bayir H, Kagan VE. 2014. Imaging mass spectrometry of diversified cardiolipin molecular species in the brain. Anal Chem 86: 6587-95

 

联系方式:

地址:广州黄埔大道西 601 暨南大学 药学院706

电话:020-85227791

E-mailrongronghe@jnu.edu.cn