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訾佳辰
发布时间:2015-11-12

訾佳辰博士  教授   博导/硕导

 

【教育经历】

2012-2014     Iowa State University              博士后

2011- 2012  Utah State University              博士后

2009-2011  University of Illinois at Chicago       博士后

20059-20087  中国医学科学院&北京协和医学院 药物研究所      药物化学 博士

20018-20047  沈阳药科大学                    生药学  硕士 

19979-20017  沈阳药科大学                    中药学  学士

 

【工作经历】

2015-至今       暨南大学                       教授  博师生导师

2008-2009  中国医学科学院&北京协和医学院 药物研究所      助理研究员

20047-20055  北京世佳九生源药业科技有限公司  药学研究员

【研究方向】

中药/天然药物、合成生物学、化学生物学、生物信息学、基因工程、酶工程、组学以及植物细胞培养。

在国际上首次阐明了鼠尾草酸、檀香醇、蓖麻烯型二萜等重要中药药效物质的生源途径中的关键步骤,并建立基于合成生物学技术的生产体系。相关研究结果被天然产物领域顶级杂志Nat. Prod. Rep.遴选为热点报道,并且获得生物技术领域顶级杂志Trends Biotechnol.的重点评述。在JACS.Annu. Rev. Plant Biol.Angew. Chem. Int. Ed.PNAS.Plant CellSCI期刊发表论文40余篇。申请美国专利、欧洲专利等数项,授权2项。

【所获荣誉】

2016     国家“千人计划”青年人才

2017     “暨南双百英才计划”杰出人才

2017     “彭磷基青年讲席教授”

【学术兼职】

Chinese Chemical Letters》青年编委

Frontiers in Chemistry   编委

中西医结合学会分子生药学专业委员会委员

中国民族医药学会信息与大数据分会常务理事

【代表论文】

1.  Jiachen Zi, Yuki Matsuba, Young J. Hong, Alana J. Jackson, Dean J. Tantillo, Eran Pichersky and Reuben J. Peters. Biosynthesis of lycosantalonol, a cis-prenyl derived diterpenoid. J. Am. Chem. Soc., 2014, 136: 16951-16953.

2.  Jiachen Zi, Sibongile Mafu, and Reuben J. Peters. To Gibberellins and Beyond! Surveying the Evolution of (Di)terpenoid Metabolism. Annu. Rev. Plant Biol., 2014, 65, 259-286.

3.  Kevin C. Potter, Jiachen Zi, Young J. Hong, Samuel Schulte, Brandi Malchow, Dean J. Tantillo, Reuben J. Peters. Blocking deprotonation with retention of aromaticity in a plant ent-copalyl diphosphate synthase leads to product rearrangement. Angew. Chem. Int. Ed. 201655 (2): 634-638.

4.  Sibongile Mafu, Meirong Jia, Jiachen Zi, Dana Morrone, Yisheng Wu, Meimei Xu, Matthew L. Hillwig, Reuben J. Peters. Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis. Proc. Natl. Acad. Sci., 2016, 113: 2526-2531.

5.  Alexander Boutanaev, Tessa Moses, Jiachen Zi, David Nelson, Sam Mugford, Reuben J. Peters and Anne Osbourn. Investigation of terpene diversification across multiple sequenced plant genomes. Proc. Natl. Acad. Sci., 2015, 112: E81-88.

6.  Kevin Potter, Jared Criswell, Jiachen Zi and Reuben J. Peters. Novel product chemistry from mechanistic analysis of ent-copalyl diphosphate synthases from plant hormone biosynthesis. Angew. Chem. Int. Ed., 2014, 53, 7198-7202.

7.  Dayu Yu, Fuchao Xu, Jiachen Zi, Siyuan Wang, David Gage, Jia Zeng, Jixun Zhan. Engineered production of fungal anticancer cyclooligomer depsipeptides in Saccharomyces cerevisiae. Metab. Eng., 2013, 18, 60-68.

8.  Jiachen Zi and Reuben J. Peters. Characterization of CYP76AH4 clarifies plant phenolic diterpenoid biosynthesis. Org. Biomol. Chem., 2013, 11, 7650-7652.

9.   Jiachen Zi, Daniel Lantvit, Steven M. Swanson, Jimmy Orjala. Lyngbyaureidamides A and B, Two Anabaenopeptins from the Cultured Freshwater Cyanobacterium Lyngbya sp. Phytochemistry. 2012, 74, 173-177.

10.  Jiachen Zi, Shuai Li, Mingtao Liu, Maoluo Gan, Sheng Lin, Weixia Song, Yanling Zhang, Xiaona, Fan, Yongchun Yang, Jianjun Zhang, Jiangong Shi, Duolong Di. Glycosidic Constituents of the tubers of Gymnadenia conopsea., J. Nat. Prod. , 2008, 71, 799-805.

11. Santosh  Kumar, Chase  Kempinski, Xun  Zhuang, Ayla  Norris, Sibongile  Mafu, Jiachen Zi, Stephen  A.  Bell, Stephen  Eric  Nybo, Scott  E.  Kinison, Zuodong  Jiang, Sheba Goklany, Kristin B. Linscott, Xinlu Chen, Qidong Jia Shoshana D. Brown, John L. Bowman, Patricia C. Babbitt, Reuben J. Peters, Feng Chen, Joe Chappell. Molecular Diversity of Terpene Synthases in the Liverwort Marchantia polymorpha. Plant Cell, 2016, doi:10.1105/tpc.16.00062.