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陈河如
发布时间:2014-07-18

陈河如,男,博士,教授,博士/硕士生导师。19896月毕业于中山大学化学系,获理学学士学位及优秀毕业生称号;19956月毕业于中国科学院上海有机化学研究所并获理学硕士学位;19995月赴香港大学化学系进行合作研究,任助理研究员;200211月毕业于香港科技大学化学系并获哲学(化学)博士学位,同年赴加拿大蒙特利尔临床研究院(Clinical Research Institute of MontrealCanada)进行合作研究,任博士后研究员。20072月赴德国Wuppertal大学进行学术访问,20082月回国。1989.7-2008.2期间,曾断续在汕头大学工作,历任助教、讲师、副教授、汕头大学多学科研究中心顾问等职。2008.3至今,任暨南大学药学院药物化学教授, 博士生导师。多年来从事天然产物的结构修饰、药物合成、有机合成、多肽科学及生物有机化学等领域的研究工作。已经主持和参加多项项国家自然科学基金项目、广东省自然科学基金重点项目、广东省科技厅社会发展重点项目、广东省高等院校自然科学研究重点项目和多项其它基金,已在国际及国内重要刊物发表论文100余篇,获授权专利9项,申请国际PCT专利2项。

 

主要研究方向:

 

天然产物的结构修饰及全合成、新药设计/合成/作用机理研究、药物合成工艺研究

 

近五年25篇代表性论文(打*者为通讯作者):

 

1.         Minfeng Chen, Xueping Lei, Changzheng Shi, Baojian Wu, Zhengqiu li, Bin Du, Weili Han, Jianyang Hu, Qiulin Nie, Zhenjian Zhuo, Weiqian Mai, Maohua Huang, Nan Ma, Nanhui Xu, Xinyi Zhang, Liangping Luo, Ande Ma, HongSheng Li, Qiang Yu, Heru Chen*, Dongmei Zhang*, Wencai Ye*. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest. 2017, doi:10.1172/JCI94258 (IF 12.78).

2.         Laitao Zhang#, Yifang Li#, Sheng Yuan#, Shijie Zhang, Huanhuan Zheng, Jie Liu, Pinghua Sun, Yijun Gu, Hiroshi Kurihara, Rongrong He*, Heru Chen*. Bioactivity Focus of a-Cyano-4-hydroxycinnamic acid (CHCA) Leads to Effective Multifunctional Aldose Reductase Inhibitors. Sci Report 2016, 6, 24942, doi: 10.1038/srep24942 (IF 5.28).

3.         Zhihua Wang, Sheng Yuan, Yanbing Li, Zhe Zhang, Wei Xiao, Dan Tang, Kaihe Ye, Zhijun Liu, Congcong Wang, Yixiong Zheng, Hong Nie*, Heru Chen*. Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications. Biochem Pharmacology 2018, 150, 54-63. https://doi.org /10.1016/j.bcp.2018.01.034  (IF 5.09).

4.         Jie Liu, Chao Zhang, Huailin Wang, Lei Zhang, Jianrun Zhang, Zhenlei Jiang, Zhijun Liu, Heru Chen*. Design synthesis of 1,3-dioxyxanthone nitrates and the studies on the synergistic anticancer activities. Eur. J. Med. Chem. 2018, 151, 158-172 (IF 4.59).

5.         Jie Liu, Fan Zhou, Lei Zhang, Huailin Wang, Jianrun Zhang, Chao Zhang, Zhenlei Jiang, Yanbing Li, Zhijun Liu, Heru Chen*. DMXAA-pyranoxanthone hybrids enhance inhibition activities against human cancer cells with multi-target functions. Eur. J. Med. Chem. 2018, 143, 1768-1778 (IF 4.59).

6.         Jie Liu, Fan Zhou, Lei Zhang, Huailin Wang, Jianrun Zhang, Chao Zhang, Zhenlei Jiang, Yanbing Li, Zhijun Liu, Heru Chen*. DMXAA-pyranoxanthone hybrids enhance inhibition activities against human cancer cells with multi-target functions. Eur. J. Med. Chem. 2018, 143, 1768-1778 (IF 4.59)

7.         Jie Liu, Jianrun Zhang, Huailin Wang, Zhijun Liu, Chao Zhang, Zhenlei Jiang, Heru Chen*. Synthesis of xanthone derivatives and the studies on the inhibition against cancer cells growth and synergistic effects of them. Eur. J. Med. Chem. 2017, 133, 50-61 (IF 4.59).

8.         Fu-xiang Jiang, Qiao-zhen Liu, Dan Zhao, Cui-ting Luo, Cui-ping Guo, Wen-cai Ye, Cheng Luo, Heru Chen*. A concise synthesis of N-substituted fagomine derivatives and the systematic exploration of their a-glycosidase inhibition. Eur J Med Chem 2014, 77, 211-222. IF 3.9

9.         Jing Zheng, Lijuan Deng, Minfeng Chen, Xuzhi Xiao, Shengwei Xiao, Cuiping Guo, Gaokeng Xiao, Liangliang Bai, Wencai Ye, Dongmei Zhang*, Heru Chen*. Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity. Eur J Med Chem, 2013, 65, 158-167 IF 3.5

10.     Wang, R., Yang, J., Peng, L., Zhao, J., Mu, N., Huang, J., Lazarovici, P., Chen, H.*, and Zheng, W.* Gardenamide A attenuated cell apoptosis induced by serum deprivation via ERK1/2 and PI3K/Akt signaling pathways. Neuroscience 2015, 286, 242-250. (IF3.3)

11.     Rikang Wang, Jiaqiang Zhao, Lei Zhang, Xinyi Zhang, Wenhua Zheng*, and Heru Chen*. Genipin Derivatives Protect RGC-5 from Sodium Nitroprusside-Induced Nitrosative Stress. Int. J. Mol. Sci. 2016, 17(1), 117; doi: 10.3390/ijms 17010117 (IF 3.15).

12.     Jiaqiang Zhao, Lizhi  Peng , Rikang  Wang , Lei Zhang, Xinyi Zhang, Jian Yang, Wenhua Zheng*, Heru Chen*. Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects Against Corticosterone-Induced Insults in PC12 Cells. Int. J. Mol. Sci. 2015, (IF2.8)

13.     Rikang Wang, Lizhi Peng, Jiaqiang Zhao, Laitao Zhang, Cuiping Guo, Wenhua Zheng*, Heru Chen*. Gardenamide A Protects RGC-5 Cells from H2O2-induced Oxidative Stress Insults by Activating PI3K/Akt/eNOS Signaling Pathway. Int. J. Mol. Sci. 2015, (IF2.8)

14.     Wang, R., Yang, J., Zhang, L., Xiao, G., Luo, J., Liao, S., Chen, H.*, and Zheng W.* Stereoselective Reduction of 1-O-Isopropyloxygenipin Enhances Its Neuroprotective Activity against Apoptosis in PC12 Cells Induced by Sodium Nitroprusside. ChemMedChem 2014, 9(7), 1397-1401. IF 3.15

15.     Huan-huan Zheng, Cui-ting Luo, Heru Chen*, Juan-na Lin, Chun-lin Ye, Shuang-shuang Mao, Yu-lin Li. Xanthones from Swertia mussotii as multi-target-directed anti-diabetic agents. ChemMedChem 2014, 9(7), 1378-1386.. (IF 3.15)

16.     Luo, J., Wang, R. –K., Huang, Z., Yang, J., Yao, X. –S., Chen, H. R.*, Zhen, W. –H.* Synthesis of Stable Derivatives from Genipin and Studies of Their Neuroprotective Activity in PC12 Cells. ChemMedChem 2012, 7(9), 1661-1668IF 3.15

17.     Cui-ting Luo, Huan-huan Zhen, Shuang-shuang Mao, Mao-xun Yang, Cheng Luo, Heru Chen*. Xanthones from Swertia mussotii and their a-glycosidase inhibitory activities. Planta Medica 2014, 80, 201-208  (IF 2.23)

18.     Cui-ting Luo, Shuang-shuang Mao, Fang-lan Liu, Mao-xun Yang, Hiroshi Kurihara, Yulin Li, Heru Chen*. Antioxidant Xanthones from Swertia mussotii, a High Altitude Plant. Fitoterapia 2013, 91, 140-147 (IF 2.15)

19.     张馨怡, 袁盛, 赵家强, 张磊, 张潮, 王日康, 陈河如. 栀子酰胺A-他克林杂合体的设计合成及其对6-羟多巴胺诱导的PC12细胞损伤的保护作用. 有机化学 2017, 37, 873-880.

20.     许男徽, 陈河如*.  (1aRS,7aRS)-7-羟基氨亚基-1,1a,7,7a-4H-丙环骈[b]色烯-1a-甲酸乙酯及其衍生物的有效全合成. 有机化学  2015, 35(5), 1033-1039.

21.     肖胜伟, 刘志军, 柳杨, 陈河如*. 抗癌药物达卡巴嗪的合成工艺优化. 有机化学 2015, 35(5), 1161-1165.

22.     毛双双, 郑欢欢, 罗翠婷, 陈河如*. 1,3-二羟基呫吨酮类化合物的简洁合成及清除亚硝酸根作用研究. 有机化学2014, 34(3), 515-521.

23.     国翠平, 彭群龙, 潘龙, 张冬梅, 陈河如*. 吡唑环桥连简约型长春碱类似物的设计合成. 有机化学 2014, 34(12), 2505-2510.

24.     Lei Zhang, Xinyi Zhang, Laitao Zhang, Lizhi Peng, Jie Liu, Cuiping Guo, Cheng Luo, Heru Chen *. Incorporation of Dihydroartemisinin into Memantine through A Propriate Spacer Makes the Hybrid with Enhancing Effects to Protect PC12 Cells from Corticosterone–Caused Impairments. 高等学校化学研究 2017, 33(4), 611-622.

25.     Heru Chen*, Cao Zhang, Zhenlei Jiang, Jiu Liu. Structural modification based on natural products leads to more drug-like candidates. 结构化学 2017, 36(12), 1947-1960 (综述).

 

授权国家发明专利

 

1.         陈河如,杨炀,江振友. 一种线性多肽及其合成方法和应用. 2012.10.17, 中国,ZL 201010226536.7

2.         陈河如,陈道煌,江振友. 一种假环多肽及其合成方法和应用. 2012.10.17,中国,ZL 201010226527.8

3.         陈河如,江富祥,刘巧珍,王果,吕秋兰. N-取代fagomine衍生物及其合成方法与用途. 2014.08.06, 中国发明专利, ZL 201210365319.5

4.         陈河如,罗翠婷,毛双双,杨懋勋,李玉林. 一种具有a-糖苷酶抑制活性的化合物的制备方法和应用. 中国发明专利, ZL 201210568016.3

5.         杨懋勋, 陈河如, 梁耀光, 张天佑, 谢朝良, 蒋建平, 高滇淦, 李小玉. 一种利用高速逆流色谱分离白木香片叶中活性成分的方法. 中国发明专利, ZL 201310062910.8

6.         陈河如, 叶文才, 张冬梅, 陈敏锋, 肖绪枝, 许男徽, 雷雪萍, 胡坚杨. 一种吲哚生物碱加合物及其制备方法和在制备抗肿瘤药物中的应用. 中国发明专利,ZL 201310138241.8

7.         陈河如,李怡芳,何蓉蓉. 一种a-氰基-4-羟基肉桂酸衍生物及其制备方法和用途. 中国发明专利,ZL 201410723116.8

8.         陈河如, 张来涛, 彭丽芝. 二氢青蒿素-美金刚二联体化合物及其合成方法和用途. 中国国家发明专利, ZL 20160061614.X, 授权日2017.12.12.

9.         叶文才, 陈河如, 张冬梅, 陈敏峰, 许男徽. 长春碱类衍生物及其制备方法和应用. 中国发明专利, ZL201480022198.1, 授权日2018.02.02.

 

 

l  国际PCT发明专利申请

 

1.  叶文才, 陈河如, 张冬梅, 陈敏峰, 许男徽. 长春碱类衍生物及其制备方法和应用. PCT, 申请号PCT/CN2014/000192, 申请日2014.03.03. (进入国别申请阶段)

2.  陈河如, 李怡芳, 何蓉蓉, 聂红, 郑欢欢, 袁盛. 一种a-氰基-4-羟基肉桂酸衍生物及其制备方法和用途. PCT, 申请号PCT/CN2015/095859, 申请日2015.11.27.

 

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