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叶文才
发布时间:2014-05-28

 

叶文才,理学博士,教授、博士生导师,长江学者特聘教授、国家杰出青年科学基金获得者。19837月毕业于南京药学院(现中国药科大学)中药学专业,获学士学位;19838-198810月在安徽中医药高等专科学校任教;198811-19977月在中国药科大学天然药物化学教研室任教,先后任讲师、副教授;19978-200110月在香港科技大学化学系学习,获博士学位;200112月起任中国药科大学教授、博士生导师;20028-20167月先后担任暨南大学中药及天然药物研究所常务副所长,中药系主任,药学院副院长、院长。201410月起任暨南大学副校长。

长期从事中药和天然药物活性成分、天然产物化学生物学、中药和天然药物来源的创新药物等研究工作。先后主持了国家重点研发计划、国家杰出青年科学基金、国家自然科学基金重点项目、国家自然科学基金-广东联合基金重点项目、国家重大科技专项和科技支撑计划、教育部长江学者创新团队、广东省珠江人才计划团队项目、广东省自然科学基金团队项目、广东省和广州市重大科技专项等科研项目40余项。已发表研究论文700余篇(其中SCI收录论文400余篇)2014-2017年连续被Elsevier列为中国高被引学者榜单。获授权国内外发明专利36项,获一类和五类中药新药临床研究批件各1项。以第一完成人获国家科技进步奖二等奖1项、广东省科学技术奖一等奖2项,获中国专利优秀奖、中国产学研合作创新成果奖一等奖各1项。主要成果之一“中药和天然药物的三萜及其皂苷成分研究与应用”入选2017年中国十大医学进展。讲授了多门本科生和研究生课程,培养硕士和博士研究生100余名。

现兼任国家药典委员会委员、中国植物学会植物化学与资源学专业委员会副主任委员、广东省药学会副理事长、广东省学位委员会委员、广东省高校设置评议委员会委员、多个国家及省部级重点实验室学术委员会委员。获中国药学发展奖(人物奖)、国务院政府特殊津贴、广东省丁颖科技奖、国家杰出青年科学基金、教育部长江学者特聘教授、新世纪百千万人才工程国家级人选,并获全国模范教师、全国优秀科技工作者称号。

 

主要研究方向:

1. 中药及天然药物活性成分
2.
活性天然产物的化学生物学研究
3.
中药及天然药物来源的创新药物研究

 

代表性论文:

1           Wu ZL, Zhao BX, Huang XJ, Tang GY, Shi L, Jiang RW, Liu X, Wang Y*, Ye WC*. Suffrutines A and B: A pair of Z/E isomeric indolizidine alkaloids from the roots of Flueggea suffruticosa. Angewandte Chemie, International Edition, 2014, 53: 5796-5799.

2           Chen MF, Lei XP, Shi CZ, Huang MH, Li XB, Wu BJ, Li ZQ, Han WL, Du B, Hu JY, Nie QL, Mai WQ, Ma N, Xu NH, Zhang XY, Fan CL, Hong AH, Xia MH, Luo LP, Ma AD, Li HH, Yu Q, Chen HR*, Zhang DM*, Ye WC*. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. The Journal of Clinical Investigation, 2017, 127: 3689-3701.

3           Lei XP, Chen MF, Huang MH, Li XB, Shi CZ, Zhang D, Luo LP, Zhang YW, Ma N, Chen HR, Liang HF, Ye WC*, Zhang DM*. Desacetylvinblastine Monohydrazide Disrupts Tumor Vessels by Promoting VE-cadherin Internalization. Theranostics, 2018, 8: 384-398.

4           Cheng MJ, Cao JQ, Yang XY, Zhong LP, Hu LJ, Lu X, Hou BL, Hu YJ, Wang Y, You XF, Wang L*, Ye WC*, Li CC*. Catalytic Asymmetric Total Syntheses of Myrtucommuacetalone, Myrtucommuacetalone B and Callistrilones A, C, D, E. Chemical Science, Doi:10.1039/c7sc04672c.

5           Zhang DM, Xu HG, Wang L, Li YJ, Sun PH, Wu XM, Wang GJ, Chen WM*, Ye WC*. Betulinic acid and its derivatives as potential antitumor agents. Medicinal Research Reviews, 2015, 35: 1127-1155.

6           Ip FCF, Fu WY, Cheng EYL, Tong EPS, Lok KC, Liang Y, Ye WC*, Ip NY*. Anemoside A3 enhances cognition through the regulation of synaptic function and neuroprotection. Neuropsychopharmacology, 2015, 40: 1877-1887.

7           Yu B, Guan M, Peng Y, Shao Y, Zhang C, Yue X, Zhang J, Yang H, Zou H, Ye WC*, Wan J*, Zhang W*. Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus. Arthritis & Rheumatism, 2011, 63: 3487-3492.

8           Zhang W, Xu W, Wang GY, Gong XY, Li NP, Wang L*, Ye WC*. Gelsekoumidines A and B: Two Pairs of Atropisomeric Bisindole Alkaloids from the Roots of Gelsemium elegans. Organic Letters, 2017, 19: 5194-5197.

9           Zhang YB, Zhang XL, Chen NH, Wu ZN, Ye WC*, Li YL*, Wang GC*. Four matrine-based alkaloids with antiviral activities against HBV from the seeds of Sophora alopecuroides. Organic Letters, 2017, 19, 424-427.

10       Deng LJ, Wang LH, Peng CK, Li YB, Huang MH, Chen MF, Lei XP, Qi M, Cen Y, Ye WC*, Zhang DM*, Chen WM*. Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity. Journal of Medicinal Chemistry, 2017, 60, 5320-5333.

11       Cao JQ, Huang XJ, Li YT, Wang Y, Wang L*, Jiang RW, Ye WC*. Callistrilones A and B, Triketone-Phloroglucinol-Monoterpene Hybrids with a New Skeleton from Callistemon rigidus. Organic Letters, 2016, 18: 120-123.

12       Liu C, Ang S, Huang XJ, Tian HY, Deng YY, Zhang DM, Wang Y, Ye WC*, Wang L*. Meroterpenoids with New Skeletons from Myrtus communis and Structure Revision of Myrtucommulone K. Organic Letters, 2016, 18, 4004-4007.

13       Li XL, Zhao BX, Huang XJ, Zhang DM, Jiang RW, Li YJ, Jian YQ, Wang Y*, Li YL*, Ye WC*. (+)- and (-)-Cajanusine, a pair of new enantiomeric stilbene dimers with a new skeleton from the leaves of Cajanus cajan. Organic Letters, 2014, 16: 224-227.

14       Ma N, Yao YW, Zhao BX, Wang Y, Ye WC*, Jiang S*. Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine A. Chemical Communication, 2014, 50: 9284-9287.

15       Liu J, Zhang D, Li Y, Chen W, Ruan Z, Deng L, Wang L, Tian H, Yiu A, Fan C, Luo H, Liu S, Wang Y, Xiao G, Chen L*, Ye WC*. Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor Activities. Journal of Medicinal Chemistry, 2013, 56, 5734-5743.

16       Shao M, Wang Y*, Jian YQ, Huang XJ, Zhang DM, Tang QF, Jiang RW, Sun XG, Lv ZP, Zhang XQ*, Ye WC*. Guadial A and Psiguadials C and D, Three Unusual Meroterpenoids from Psidium guajava. Organic Letters, 2012, 14: 5262-5265.

17       Zhao BX, Wang Y*, Zhang DM, Huang XQ, Bai LL, Yan Y, Chen JM, Lu TB, Wang YT, Zhang QW*, Ye WC*. Virosaines A and B, Two New Birdcage-Shaped Securinega Alkaloids with an Unprecedented Skeleton from Flueggea virosa. Organic Letters, 2012, 14: 3096-3099.

18       Wang CQ, Wang L, Fan CL, Zhang DM, Huang XJ, Jiang RW, Bai LL, Shi JM, Wang Y, Ye WC*. Ilelic Acids A and B, two unusual triterpenes with a seven-membered ring from Ilex latifolia. Organic Letters, 2012, 14: 4102-4105.

19       Zhao BX, Wang Y, Zhang DM, Jiang RW, Wang GC, Shi JM, Huang XJ, Chen WM, Che CT, Ye WC*. Flueggines A and B, two new dimericindolizidine alkaloids from Flueggea virosa. Organic Letters, 2011, 13: 3888-3891.

20       Shao M, Wang Y, Liu Z, Zhang DM, Cao HH, Jiang RW, Fan CL, Zhang XQ, Chen HR, Yao XS, Ye WC*. Psiguadials A and B, two novel meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Organic Letters, 2010, 12: 5040-5043.

21       Zhang YB, Zhan LQ, Li GQ, Wang F, Wang Y, Li YL*, Ye WC*, Wang GC*. Dimeric Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Anti-Hepatitis B Virus Activities. Journal of Organic Chemistry, 2016, 81, 6273-6280.

22       Tian HY, Wang L, Zhang XQ, Wang Y, Zhang DM, Jiang RW, Liu Z, Liu JS, Li YL, Ye WC*. Bufogargarizins A and B: two novel 19-norbufadienolides with unprecedented skeletons from the venom of Bufo bufo gargarizans. Chemistry-A European Journal, 2010, 16: 10989-10993.

23       Jian YQ, Huang XJ, Zhang DM, Jiang RW, Chen MF, Zhao BX, Wang Y*, Ye WC*. Guapsidial A and guadials B and C: Three new meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Chemistry-A European Journal, 2015, 21: 9022-9027.

24       Zhang DM, Liu JS, Deng LJ, Chen MF, Yiu A, Cao HH, Tian HY, Fung KP, Kurihara H, Pan JX, Ye WC*. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis, 2013, 34: 1331-1342.

25       Shi JM, Bai LL, Zhang DM*, Yiu A, Yin ZQ, Han WL, Liu JS, Li Y, Fu DY, Ye WC*. Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress. Biochemical Pharmacology, 2013, 85(7): 913-926.

26       Li MM, Wu SA, Liu Z, Zhang W, Xu J, Wang Y, Liu JS, Zhang DM, Tian HY, Li YL*, Ye WC*. Arenobufagin, abufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGF-2 signaling pathway. Biochemical Pharmacology, 2012, 83(9): 1251-1260.

27       Zhang DM, Shu C, Chen JJ, Sodani K, Wang J, Bhatnagar J, Lan P, Ruan ZX, Xiao ZJ, Ambudkar SV, Chen WM, Chen ZS, Ye WC*. BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo. Molecular Pharmaceutical, 2012, 9(11): 3147-3159.

28       Tang GY, Liu X, Ma N, Huang XJ, Wu ZL, Zhang W, Wang Y, Zhao BX, Wang ZY, Ip FCF, Ip NY*, Ye WC*, Shi L*, Chen WM*. Design and Synthesis of Dimeric Securinine Analogues with Neuritogenic Activities. ACS Chemical Neuroscience, 2016, 7, 1442-1451.

29       Tian HY, Ruan LJ, Yu T, Zheng QF, Chen NH, Wu RB, Zhang XQ, Wang L, Jiang RW*, Ye WC*. Bufospirostenin A and Bufogargarizin C, Steroids with Rearranged Skeletons from the Toad Bufo bufo gargarizans. Journal of Natural Products, 2017, 80, 1182-1186.

30       Zhang W, Huang XJ, Zhang SY, Zhang DM, Jiang RW, Hu JY, Zhang XQ, Wang L*, Ye WC*. Geleganidines A-C, unusual monoterpenoid indole alkaloids from Gelsemium elegans. Journal of Natural Products, 2015, 78, 2036-2044.

 

联系方式:

E-mail: chywc@aliyun.com