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张志民
发布时间:2017-11-30

 

张志民博士研究员

主要从事结构生物学研究,通过解析蛋白质的三维结构阐述具有重要生物功能的蛋白质的作用机制,尤其是致病菌效应蛋白、天然产物合成相关蛋白和药物小分子的靶标蛋白。以第一作者或共同作者在 NatureNature Structural and Molecular BiologyNature PlantsNature CommunicationsCell ReportsPNAS等权威期刊发表文章13

 

教育经历

20032007年        中南大学    本科

20072012年        中科院上海有机化学研究所    博士

 

工作经历

2012 2017年       加州大学河滨分校(UC  Riverside)   博士后

2017              暨南大学药学院     研究员

 

研究兴趣

结构生物学生物化学

 

代表性文章

1. Zhang ZM#, Lu R#, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG*, Song J*. Structural basis for DNMT3A-mediated de novo DNA methylation. Nature. Aceepted

2. Zhang ZM#, Ma KW#, Gao L#, Hu Z, Schwizer S, Ma W*Song J*.  Mechanism of host substrate acetylation by a YopJ family effector. Nature Plants. (2017) 3(8):17115

3. Wang B, Tan XF, Thurmond S, Zhang ZM, Lin A, Hai R*Song J*. The structure of Zika virus NS5 reveals a conserved domain conformation. Nature Communications. (2017) 8:14763.

4. Zhang ZM#, Ma KW#, Yuan S, Luo Y, Jiang S, Hawara E, Pan S, Ma W*Song J*. Structure of a pathogen effector reveals enzymatic mechanism of a novel acetyltransferase family. Nature Structural & Molecular Biology. (2016) 23:847-52.

5. Harter MR, Liu CD, Shen CL, Gonzalez-Hurtado E, Zhang ZM, Xu M, Martinez E, Peng CW, Song J*.  BS69/ZMYND11 C-terminal domains bind and inhibit EBNA2. Plos Pathog. (2016) 12(2): e1005414.

6. Jin SG, Zhang ZM, Dunwell TL, Harter MR, Wu X, Johnson J, Li Z, Liu J, Szabo PE, Lu Q, Xu GL, Song J*, Pfeifer GP*. Tet3 reads 5-carboxylcytosine through its CXXC domain and is a potential guardian against neurodegeneration. Cell Rep. (2016) 14:493-505.

7. Zhang C, Brown MQ, ven de W, Zhang ZM, Wu B, Young MC, Synek L, Borchardt D, Harrison R, Pan S, Luo N, Huang YM, Ghang YJ, Ung N, Li R, Isley J, Morikis D, Song J, Guo W, Hooley RJ, Chang CE, Yang Z, Zarsky V, Muday GK, Hicks GR, Raikhel NV*. Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis. Proc Natl Acad Sci U S A. (2016) 113(1):E41-50.

8. Zhang ZM, Rothbart SB, Allison DF, Cai Q, Harrison JS, Li L, Wang Y, Strahl BD, Wang GG, Song J*. An allosteric interaction links USP7 to deubiquitination  and chromatin targeting of UHRF1. Cell Rep. (2015) 12:1400-6.

9. Zhang ZM, Liu S, Lin K, Luo Y, Perry JJ, Wang Y, Song J*. Crystal Structure of Human DNA Methyltransferase 1. J. Mol. Biol. (2015) 427: 2520-31

10. Li J, Wang C, Zhang ZM, Cheng YQ, Zhou J*. The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci. Rep. (2014) 4:4145

11. Zhang ZM#, Yang F#, Zhang J, Tang Q, Li J, Gu J, Zhou J*, Xu YZ*. Crystal Structure Of Prp5P Reveals Interdomain Interactions That Impact Spliceosome Assembly. Cell Rep. (2013) 5(5) DOI10.1016/j.celrep.2013.10.047

12. Yang F, Wang XY, Zhang ZM, Pu J, Fan YJ, Zhou J, Query C, Xu YZ. Splicing proofreading at 5 splice sites by ATPase Prp28p. Nucl. Acids Res. (2013) 41(8) DOI 10.1093/nar/gkt149

13. Zhang ZM#, Zhang X#, Chou S, Hu HY, Liu M, Zhou B, Zhou J. Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t. J. B. NMR. (2013) 55(2) DOI 10.1007/s 10858-012-9695-5