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张志民
发布时间:2017-11-30

张志民,博士,研究员。主要从事结构生物学研究,通过解析蛋白质的晶体结构,并结合核磁共振、分子生物学、生物化学、计算机模拟和生物信息学等手段,阐述具有重要生物功能的蛋白质的作用机制。研究方向包括:1)致病因子(effector protein)的结构和作用机制研究;2)表观遗传学中关键蛋白的结构和功能研究;3)天然产物合成相关蛋白和药物小分子的靶标蛋白。近年来以第一作者身份在NatureNature Structural& Molecular BiologyNature PlantsCell Reports等权威期刊发表7篇,并以共同作者在PNASNature CommunicationsPLOS Pathogen等发表论文7篇。

联系方式

Emailzhangzm@jnu.edu.cn   or  13632107756@163.com

办公室:药学院318

教育经历

20079–20126月中科院上海有机化学研究所     博士

20039–20076月年中南大学     学士

工作经历

20178    暨南大学药学院      研究员

20128– 20178月加州大学河滨分校(UC  RiversideDr. Jikui Song实验室    博士后

研究兴趣

结构生物学,生物化学,表观遗传学

代表性文章:

1Zhi-Min Zhang#, Rui Lu#, Pengcheng Wang, Yang Yu, Dongliang Chen, LinfengGao, Shuo Liu, DebinJi, Scott B Rothbart, Yinsheng Wang, Gang Greg Wang*&Jikui Song*. Structural basis for DNMT3A-mediated de novo DNA methylation, Nature, 2018, 554(7692): 387-391

2Zhi-Min Zhang#, Ka-Wai Ma#, Linfeng Gao#, Zhenquan Hu, Simon Schwizer, Wenbo Ma*, and Jikui Song*, Mechanism of Host Substrate Acetylation by a Yopj Family Effector, Nature Plants, 2017, 3:17115.

3Zhi-Min Zhang#, Ka-Wai Ma#,ShuguangYuan, YoufuLuo, ShushuJiang, EvaHawara, SongqinPan, WenboMa*, JikuiSong*. Structure of a pathogen effector reveals enzymatic mechanism of a novel acetyltransferase family, Nat. Struct & Mol. Biol.,2016, 23(9):847-852.

4Zhi-Min Zhang, Scott BRothbart, David F.Allison, QianCai, Joseph S.Harrison, Lin Li, YinshengWang, Brian D.Strahl, GangGreg Wang, JikuiSong. An allosteric interaction links USP7 to deubiquitination and chromatin targeting of UHRF1, Cell Rep.,2015, 12(9):1400-1406.

5Zhi-Min Zhang#, FeiYang#, JinruZhang, QingTang, JieLi, JiahaiZhou*, Yong-ZhenXu*, Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly, Cell Rep., 2013, 5(5):1269-1278

6Seung-Gi Jin, Zhi-Min Zhang, Thomas L.Dunwell, Matthew R. Harter, Xiwei Wu, JenniferJohnson, ZhengLi, JianchengLiu, PiroskaE.Szabo, QiangLu, Guo-LiangXu, JikuiSong*, GerdP.Pfeifer*, Tet3 reads 5-carboxylcytosine through its CXXC domain and is a potential guardian against neurodegeneration, Cell Rep., 2016, 14(3):493-505.

7BoxiaoWang#, Xiao-FengTan#, Stephanie Thurmond, Zhi-Min Zhang, AsherLin, RongHai*, JikuiSong *. The structure of Zika virus NS5 reveals a conserved domain conformation, Nat. Commun., 2017, 8:14763.

8Chunhua Zhang, Michelle Q. Brown, Wilhelmina van de Ven, Zhi-Min Zhang, Bin Wu, Michael C. Young, LukášSynek, Dan Borchardt, Reed Harrison, Songqin Pan, Nan Luo, Yu-ming M. Huang, Yoo-Jin Ghang, Nolan Ung, Ruixi Li, Jonathan Isley, Dimitrios Morikis, Jikui Song, Wei Guo, Richard J. Hooley, Chia-en A. Chang, Zhenbiao Yang, Viktor Zarsky, Gloria K. Muday, Glenn R. Hicks, Natasha V. Raikhel, Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis, Proc. Natl. Acad. Sci. U S A., 2016, 113(1):E41-50.

9Fei Yang, Xiu-YeWang, Zhi-Min Zhang, JiaPu, Yu-JieFan, JiahaiZhou, Charles C.Query, Yong-ZhenXu.Splicing proofreading at 5’ splice sites by ATPase Prp28p, Nucl. Acids Res., 2013, 41(8):4660-4670

(10) Matthew R. Harter, Cheng-Der Liu, Chih-Lung Shen, Elsie Gonzalez -Hurtado, Zhi-Min Zhang, Muyu Xu, Ernest Martinez, Chih-Wen Peng, and Jikui Song, 'Bs69/Zmynd11 C-Terminal Domains Bind and Inhibit Ebna2, PLOS Pathog., 2016, 12:e1005414.

(11) Zhi-Min Zhang, Shuo Liu, Krystal Lin, Youfu Luo, John Jefferson Perry, Yinsheng Wang, and Jikui Song, 'Crystal Structure of Human DNA Methyltransferase 1', J. Mol. Biol, 2015, 427(15): 2520-31.

(12) Zhi-Min Zhang#, Xu Zhang#, Zi-Ren Zhou, Hong-Yu Hu, Maili Liu, Bo Zhou, and Jiahai Zhou, Solution Structure of the Magnaporthe Oryzae Avirulence Protein Avrpiz-T, Journal of Biomolecular NMR, 2013, 55 (2): 219-23.

(13) Linfeng Gao, Xiao-Feng Tan, Shen Zhang, Tianchen Wu, Zhi-Min Zhang, Hui-wang Ai, and Jikui Song, An Intramolecular Interaction of Uhrf1 Reveals Dual Control for Its Histone Association, Structure, 2018, 26(2): 304-311.

(14) Jie Li, Cheng Wang, Zhi-Min Zhang, Yi-Qiang Cheng, and Jiahai Zhou, The Structural Basis of an Nadp+-Independent Dithiol Oxidase in Fk228 Biosynthesis, Sci. Rep., 2014, 4: 4145.