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王峰

发布时间:2024-05-14 发布单位:药学院


王峰,男,理学博士,副研究员,硕士生导师。广东省 “千百十工程”校级培养对象。2005年获中山大学博士学位之后在暨南大学药学院基因组药物研究所从事研究和教学工作。20152016年在美国南佛罗里达大学医学院访学。


主持国家自然科学基金、广东省自然科学基金、广东省教育厅科技创新项目、广东省医学科研基金等项目,已在Theranostics, Acta Pharmacologica Sinica, BBA-Gene Regulatory Mechanisms, European Journal of Pharmacology等国内外期刊发表科研论文60余篇申请专利3授权发明专利2转让1项。担任教育部学位与研究生教育发展中心评审专家、广东省自然科学基金评审专家、广东省科技计划项目评审专家。担任British Journal of Pharmcology, Acta Pharmacologica Sinica, Cellular Physiology and Biochemistry, European Journal of Pharmacology等刊物的通讯审稿人。指导国家级和省级大学生创新训练项目多项,2009年指导本科生获广东省“挑战杯”大学生课外学术科技作品大赛三等奖 (第十届)。负责药学院硕士研究生课程《高等分子生物学》《生物技术制药》以及本科生课程《生物技术药物学》《制药生物技术》的教学工作。承担省级和校级教改课题多项,发表教改论文多篇

  

研究方向:

异常可变剪接介导的肿瘤发生及转移的分子机制;抗肿瘤反义核酸药物基因工程药物

  

主持的科研项目:

1. 广东省自然科学基金面上项目项目编号:2022A1515012636ASO-Mena通过阻止Mena基因11a外显子跳跃抑制肺癌转移的作用及分子机制2022.5-2025.5

2. 广州市基础与应用基础研究项目项目编号:202201010010ASO-Scrib 反义核酸通过阻止Scrib 基因16 号外显子跳跃抑制乳腺癌转移的作用及分子机制,2022.4.1-2024.3.31

3. 广东省自然科学基金面上项目项目编号:2017A030313561),miRNA-330-3p抑制剂抗肺癌转移作用及其调节hSOD2b异构体和EMT的分子机制研究2017.05-2020.05

4. 广东省教育厅科技创新项目项目编号:2012KJCX0017),SOD改构体及相关miRNA在抑制肿瘤发展、转移中的作用,2012.10-2014.10

5. 国家自然科学基金青年基金项目项目编号:30700704),转铁蛋白载体改善vMIP-Ⅱ药物性能的作用及其机制研究,2008.1-2010.12

  

代表性论著:

1. Bin Zhang#, Shao-han Xie#, Junyi Hu#, Si-jia Lei, Liang-hua Shen, Hongtao Liu, QingZheng, Zhiming Zhang*, Chunlian Wu*, Qiang Li*, and Feng Wang*. Truncated SCRIB isoform promotes breast cancer metastasis through HnRNP A1 mediated exon 16 skipping. Acta Pharmacologica Sinica. 2023, 44(11):2307-2321.

2. Sijia Lei#, Bin Zhang#, Luyuan Huang#, Ziyou Zheng, Shaohan Xie, Lianghua Shen, Mason Breitzig, Alexander Czachor, Hongtao Liu, Huiru Luo, Yanxia Chen, Kangshou Liu, Hanxiao Sun, Qing Zheng, Qiang Li* and Feng Wang*. SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA. Cell Death Discovery, 2021, 7(1):117doi: 10.1038/s41420-021-00498-w

3. Lianghua Shen#, Sijia Lei#, Bin Zhang#, Shuaiguang Li, Luyuan Huang, Alexander Czachor, Mason Breitzig, Yuman Gao, Meiyan Huang, Xuemei Mo, Qing Zheng, Hanxiao Sun* and Feng Wang*, Skipping of exon 10 in Axl pre-mRNA regulated by PTBP1 mediates invasion and metastasis process of liver cancer cells, Theranostics, 2020, 10(13):5719-5735. doi: 10.7150/thno.42010

4. Shuaiguang Li#, Lianghua Shen#, Luyuan Huang#, Sijia Lei, Xingdong Cai, Mason Breitzig, Bin Zhang, Annan Yang, Wenzuo Ji, Meiyan Huang, Qing Zheng, Hanxiao Sun, Feng Wang*.PTBP1 enhances exon11a skipping in Mena pre-mRNA to promote migration and invasion in lung carcinoma cells. BBA Gene Regulatory Mechanisms,2019, (1862)8:858-869.

5. Lianghua Shen, Sijia Lei, Luyuan Huang, Shuaiguang Li, Shanze Yi, Mason Breitzig, Meiyan Huang, Xuemei Mo, Hanxiao Sun, Qing Zheng, Jianing Tian, Alexander Czachor and Feng Wang*.Therapeutic effects of the rhSOD2-Hirudin fusion protein on bleomycin-induced pulmonary fibrosis in mice. European Journal of Pharmacology, 2019, 852:77-89.

6. Lianghua Shen#, Shanze Yi#, Luyuan Huang#, Shuaiguang Li, Fang Bai, Sijia Lei, Mason Breitzig,Alexander Czachor, Hanxiao Sun, Qing Zheng,Feng Wang*. miR-330-3p promotes lung cancer cells invasion, EMT and metastasis by directly targeting hSOD2b. Biotechnology and Applied Biochemistry 2019, 66(1):21-32.

7. Shuaiguang Li,Enze Yang, Lianghua Shen, Dewei Niu, Mason Breitzig, Lee Charles Tan, Xiaocong Wu, Meiyan Huang, Hanxiao Sun, Feng Wang*. The novel truncated isoform of human manganese superoxide dismutase has a differential role in promoting metastasis of lung cancer cells. Cell Biology International.2018, 42(8):1030-1040.

8. ShanzeYi#, Dewei Niu#, Fang Bai, Shuaiguang Li, Luyuan Huang, Wenyan He, Anand Prasad, Alexander Czachor, Lee Charles Tan, Narasaiah Kolliputi,Feng Wang*. Soluble expression of a human MnSOD and Hirudin fusion protein in Escherichia coli, and its effects on metastasis and invasion of 95-D cells. Journal of Microbiology and Biotechnology, 2016, 26(11):1881-1890

9. Enze Yang#, Shanze Yi#, Fang Bai, Dewei Niu, Junjie Zhong, Qiuhong Wu, Shufang Chen, Renchao Zhou*, Feng Wang*. Cloning, characterization and expression pattern analysis of copper/zinc superoxide dismutase in a highly salt tolerant mangrove (Sonneratia alba). International Journal of Molecular Science. 2016,17(1):4-15

10. Zide Zhang, Luyuan Huang, Qiuhong Wu, Enze Yang, Guang Zhang, Hanxiao Sun, Feng Wang*. A recombinant trans-membrane protein hMnSOD-R9 inhibits the proliferation of cervical cancer cells in vitro. Molecular and Cellular Biochemistry. 2014, 385(1):79-86

11. Feng Wang, Qiuhong Wu, Zide Zhang, Shufang Chen, Renchao Zhou*. Cloning, Expression, and Characterization of Iron Superoxide Dismutase in Sonneratia alba, a highly salt tolerant mangrove tree. Protein Journal, 2013, 32(4):259-265. 

12. Wang Feng, Li Xiuying, Mo Xuemei, Guang Zhang, Sun Hanxiao*. A biologically active vMIP-II-IgG3-TfN fusion protein, secreted from methylotrophic yeast Pichia pastoris. Protein Expression and Purification, 2013, 87(1):47-54.   

13. Dewei Niu, Shuaiguang Li, Shanze Yi, Lianghua Shen, Meiyan Huang, Renchao Zhou, Lee Charles Tan, Mason Breitzig, Feng Wang*. Gene cloning, protein expression and functional analysis of a type 3 metallothionein gene from Sonneratia alba with biosorption potential. Polish Journal of Environmental Studies. 2018, 27(5):2203–2212

14. Dewei Niu, Qiuhong Wu, Luyuan Huang, Enze Yang, Meiyan Huang, Yong Liu, Feng Wang*. Simple and efficient expression of codon-optimized mouse leukemia inhibitory factor in Escherichia coli. Tropical Journal of Pharmaceutical Research, 2017 , 16(4):811-818

15. Wang Feng*, Shao Mei, Yang Wenjie, Huang Luyuan. High-level Soluble Expression of Recombinant Human Manganese Superoxide Dismutase in Escherichia coli, and its Effects on Proliferation of the Leukemia Cell. Protein Expression and Purification, 2011, 77(1), 46-52   

16. Zide Zhang, Luyuan Huang, Zhihui Luo, Yong Liu, Aiyun Li, Hua Sun, Qiuhong Wu, Renwang Jiang, Feng Wang*.Expression, purification, characterization and in vitro activity of recombinant mouse Cu/Zn-binding superoxide dismutase (mSOD1). Tropical Journal of Pharmaceutical Research, 2013, 12(3):329-334. 

17. Wang Feng, Wang Hongbin, Liu Bing, Wang Jinfa*. Cloning and Characterization of a Novel Splicing Isoform of Iron-Superoxide Dismutase Gene in Rice. Plant cell reports. 2006, 24(12):734-742.

  

专利:

[1]王峰, 张自德, 黄璐圆, 吴秋红, 张光, 李秀英. 一种具有穿膜功能的hMnSOD-R9及其制备方法与应用. 2016.2.10,中国,ZL201210544100.1

  

学术获奖情况:

[1]孙晗笑,陆大祥,严群超,李秀英,莫雪梅,王峰,江振友,董军,许华,王秀清,张光,王霆,马焕丽,叶石敦,贾忠伟。病毒趋化因子vMIP封闭人趋化因子受体作用及其应用研究,2006年中华医学科技奖三等奖。

[2]孙晗笑,陆大祥,蔡绍晖,王峰,李秀英,莫雪梅,许华,江振友,董军,王秀清。人趋化因子受体拮抗剂-病毒趋化因子vMIP和人趋化因子SDF-1α突变体的研究,2006年度广东省科学技术奖二等奖。