作者登录
王峰，男，理学博士，副研究员，硕士生导师。广东省 “千百十工程”校级培养对象。2005年获中山大学博士学位，之后在暨南大学药学院基因组药物研究所从事研究和教学工作。2015年至2016年在美国南佛罗里达大学医学院访学。
主持国家自然科学基金、广东省自然科学基金、广东省教育厅科技创新项目、广东省医学科研基金等项目，已在Theranostics, Acta Pharmacologica Sinica, BBA-Gene Regulatory Mechanisms, European Journal of Pharmacology等国内外期刊发表科研论文60余篇。申请专利3项，授权发明专利2项，转让1项。担任教育部学位与研究生教育发展中心评审专家、广东省自然科学基金评审专家、广东省科技计划项目评审专家。担任British Journal of Pharmcology, Acta Pharmacologica Sinica, Cellular Physiology and Biochemistry, European Journal of Pharmacology等刊物的通讯审稿人。指导国家级和省级大学生创新训练项目多项，2009年指导本科生获广东省“挑战杯”大学生课外学术科技作品大赛三等奖 (第十届)。负责药学院硕士研究生课程《高等分子生物学》《生物技术制药》以及本科生课程《生物技术药物学》《制药生物技术》的教学工作。承担省级和校级教改课题多项，发表教改论文多篇。
研究方向：
异常可变剪接介导的肿瘤发生及转移的分子机制；抗肿瘤反义核酸药物；基因工程药物；
主持的科研项目：
1. 广东省自然科学基金面上项目（项目编号：2022A1515012636）ASO-Mena通过阻止Mena基因11a外显子跳跃抑制肺癌转移的作用及分子机制，2022.5-2025.5，
2. 广州市基础与应用基础研究项目（项目编号：202201010010），ASO-Scrib 反义核酸通过阻止Scrib 基因16 号外显子跳跃抑制乳腺癌转移的作用及分子机制，2022.4.1-2024.3.31
3. 广东省自然科学基金面上项目（项目编号：2017A030313561），miRNA-330-3p抑制剂抗肺癌转移作用及其调节hSOD2b异构体和EMT的分子机制研究，2017.05-2020.05
4. 广东省教育厅科技创新项目（项目编号：2012KJCX0017），SOD改构体及相关miRNA在抑制肿瘤发展、转移中的作用，2012.10-2014.10
5. 国家自然科学基金青年基金项目（项目编号：30700704），转铁蛋白载体改善vMIP-Ⅱ药物性能的作用及其机制研究，2008.1-2010.12
代表性论著：
1. Bin Zhang#, Shao-han Xie#, Junyi Hu#, Si-jia Lei, Liang-hua Shen, Hongtao Liu, QingZheng, Zhiming Zhang*, Chunlian Wu*, Qiang Li*, and Feng Wang*. Truncated SCRIB isoform promotes breast cancer metastasis through HnRNP A1 mediated exon 16 skipping. Acta Pharmacologica Sinica. 2023, 44(11):2307-2321.
2. Sijia Lei#, Bin Zhang#, Luyuan Huang#, Ziyou Zheng, Shaohan Xie, Lianghua Shen, Mason Breitzig, Alexander Czachor, Hongtao Liu, Huiru Luo, Yanxia Chen, Kangshou Liu, Hanxiao Sun, Qing Zheng, Qiang Li* and Feng Wang*. SRSF1 promotes the inclusion of exon 3 of SRA1 and the invasion of hepatocellular carcinoma cells by interacting with exon 3 of SRA1pre-mRNA. Cell Death Discovery, 2021, 7(1):117doi: 10.1038/s41420-021-00498-w
3. Lianghua Shen#, Sijia Lei#, Bin Zhang#, Shuaiguang Li, Luyuan Huang, Alexander Czachor, Mason Breitzig, Yuman Gao, Meiyan Huang, Xuemei Mo, Qing Zheng, Hanxiao Sun* and Feng Wang*, Skipping of exon 10 in Axl pre-mRNA regulated by PTBP1 mediates invasion and metastasis process of liver cancer cells, Theranostics, 2020, 10(13):5719-5735. doi: 10.7150/thno.42010
4. Shuaiguang Li#, Lianghua Shen#, Luyuan Huang#, Sijia Lei, Xingdong Cai, Mason Breitzig, Bin Zhang, Annan Yang, Wenzuo Ji, Meiyan Huang, Qing Zheng, Hanxiao Sun, Feng Wang*.PTBP1 enhances exon11a skipping in Mena pre-mRNA to promote migration and invasion in lung carcinoma cells. BBA Gene Regulatory Mechanisms,2019, (1862)8:858-869.
5. Lianghua Shen, Sijia Lei, Luyuan Huang, Shuaiguang Li, Shanze Yi, Mason Breitzig, Meiyan Huang, Xuemei Mo, Hanxiao Sun, Qing Zheng, Jianing Tian, Alexander Czachor and Feng Wang*.Therapeutic effects of the rhSOD2-Hirudin fusion protein on bleomycin-induced pulmonary fibrosis in mice. European Journal of Pharmacology, 2019, 852:77-89.
6. Lianghua Shen#, Shanze Yi#, Luyuan Huang#, Shuaiguang Li, Fang Bai, Sijia Lei, Mason Breitzig,Alexander Czachor, Hanxiao Sun, Qing Zheng,Feng Wang*. miR-330-3p promotes lung cancer cells invasion, EMT and metastasis by directly targeting hSOD2b. Biotechnology and Applied Biochemistry 2019, 66(1):21-32.
7. Shuaiguang Li,Enze Yang, Lianghua Shen, Dewei Niu, Mason Breitzig, Lee Charles Tan, Xiaocong Wu, Meiyan Huang, Hanxiao Sun, Feng Wang*. The novel truncated isoform of human manganese superoxide dismutase has a differential role in promoting metastasis of lung cancer cells. Cell Biology International.2018, 42(8):1030-1040.
8. ShanzeYi#, Dewei Niu#, Fang Bai, Shuaiguang Li, Luyuan Huang, Wenyan He, Anand Prasad, Alexander Czachor, Lee Charles Tan, Narasaiah Kolliputi,Feng Wang*. Soluble expression of a human MnSOD and Hirudin fusion protein in Escherichia coli, and its effects on metastasis and invasion of 95-D cells. Journal of Microbiology and Biotechnology, 2016, 26(11):1881-1890
9. Enze Yang#, Shanze Yi#, Fang Bai, Dewei Niu, Junjie Zhong, Qiuhong Wu, Shufang Chen, Renchao Zhou*, Feng Wang*. Cloning, characterization and expression pattern analysis of copper/zinc superoxide dismutase in a highly salt tolerant mangrove (Sonneratia alba). International Journal of Molecular Science. 2016,17(1):4-15
10. Zide Zhang, Luyuan Huang, Qiuhong Wu, Enze Yang, Guang Zhang, Hanxiao Sun, Feng Wang*. A recombinant trans-membrane protein hMnSOD-R9 inhibits the proliferation of cervical cancer cells in vitro. Molecular and Cellular Biochemistry. 2014, 385(1):79-86
11. Feng Wang, Qiuhong Wu, Zide Zhang, Shufang Chen, Renchao Zhou*. Cloning, Expression, and Characterization of Iron Superoxide Dismutase in Sonneratia alba, a highly salt tolerant mangrove tree. Protein Journal, 2013, 32(4):259-265.
12. Wang Feng, Li Xiuying, Mo Xuemei, Guang Zhang, Sun Hanxiao*. A biologically active vMIP-II-IgG3-TfN fusion protein, secreted from methylotrophic yeast Pichia pastoris. Protein Expression and Purification, 2013, 87(1):47-54.
13. Dewei Niu, Shuaiguang Li, Shanze Yi, Lianghua Shen, Meiyan Huang, Renchao Zhou, Lee Charles Tan, Mason Breitzig, Feng Wang*. Gene cloning, protein expression and functional analysis of a type 3 metallothionein gene from Sonneratia alba with biosorption potential. Polish Journal of Environmental Studies. 2018, 27(5):2203–2212
14. Dewei Niu, Qiuhong Wu, Luyuan Huang, Enze Yang, Meiyan Huang, Yong Liu, Feng Wang*. Simple and efficient expression of codon-optimized mouse leukemia inhibitory factor in Escherichia coli. Tropical Journal of Pharmaceutical Research, 2017 , 16(4):811-818
15. Wang Feng*, Shao Mei, Yang Wenjie, Huang Luyuan. High-level Soluble Expression of Recombinant Human Manganese Superoxide Dismutase in Escherichia coli, and its Effects on Proliferation of the Leukemia Cell. Protein Expression and Purification, 2011, 77(1), 46-52
16. Zide Zhang, Luyuan Huang, Zhihui Luo, Yong Liu, Aiyun Li, Hua Sun, Qiuhong Wu, Renwang Jiang, Feng Wang*.Expression, purification, characterization and in vitro activity of recombinant mouse Cu/Zn-binding superoxide dismutase (mSOD1). Tropical Journal of Pharmaceutical Research, 2013, 12(3):329-334.
17. Wang Feng, Wang Hongbin, Liu Bing, Wang Jinfa*. Cloning and Characterization of a Novel Splicing Isoform of Iron-Superoxide Dismutase Gene in Rice. Plant cell reports. 2006, 24(12):734-742.
专利：
[1]王峰, 张自德, 黄璐圆, 吴秋红, 张光, 李秀英. 一种具有穿膜功能的hMnSOD-R9及其制备方法与应用. 2016.2.10，中国，ZL201210544100.1
学术获奖情况：
[1]孙晗笑，陆大祥，严群超，李秀英，莫雪梅，王峰，江振友，董军，许华，王秀清，张光，王霆，马焕丽，叶石敦，贾忠伟。病毒趋化因子vMIP封闭人趋化因子受体作用及其应用研究，2006年中华医学科技奖三等奖。
[2]孙晗笑，陆大祥，蔡绍晖，王峰，李秀英，莫雪梅，许华，江振友，董军，王秀清。人趋化因子受体拮抗剂-病毒趋化因子vMIP和人趋化因子SDF-1α突变体的研究，2006年度广东省科学技术奖二等奖。
