胡亚剑

发布时间:2022-09-13 发布单位:药学院

1.简介

胡亚剑,男,博士,副研究员,硕士生导师。2021年毕业于澳门大学,获生物医药专业博士学位(导师:李闯创教授与赵静教授)。20221月以“绿色通道副高”加入暨南大学,从事教学科研工作。目前以(共同)第一作者身份,在Chem. Rev., Chem. Soc. Rev., Nat. Prod. Rep., J. Am. Chem. Soc., Org. Lett., Org. Chem. Front.等著名期刊上发表论文十余篇。值得一提的是,胡亚剑攻读博士学位期间主要从事紫杉烷二萜的全合成研究,并完成了著名抗肿瘤天然药物紫杉醇(Taxol)的国内首次全合成,这也是其代表性工作。

欢迎有志于从事天然产物合成化学、药物化学的学生加入团队!共创美好的明天!


2.研究方向

(1)活性天然产物全合成

(2)天然产物导向的有机合成方法学研究


3.教育及研究经历

2022.01-至今    暨南大学,副研究员(绿色通道)

2016.09-2021.06澳门大学,生物医药,博士(导师:李闯创教授与赵静教授)

2015.07-2016.08南方科技大学,研究助理(导师:李闯创教授)

2012.09-2015.06中国药科大学,药物化学,硕士(导师:孔令义教授)

2008.09-2012.06黑龙江八一农垦大学,生物工程,学士


4.主持科研项目

(1)国家自然科学基金青年科学基金项目,22201104,复杂天然产物CanataxpropellaneTaxpropellane的全合成研究,2023-01-012025-12-3124万元,在研,主持。

(2)中央高校基本科研业务费项目,21622328,灵芝杂萜Applanatumol ASpiroapplanatumines A-I的全合成研究,2022-01-012023-12-319万元,在研,主持。


5.代表性论文

#表示“共同一作”; *表示“通迅作者”.

 (1) Ya-Jian Hu#, Chen-Chen Gu#, Xin-Feng Wang#, Long Min, Chuang-Chuang Li*. Asymmetric Total Synthesis of Taxol.J. Am. Chem. Soc.2021, 143, 17862-17870. (IF = 16.383)

 (2) Jian-Hong Fan#, Ya-Jian Hu#, Li-Xuan Li#, Jing-Jing Wang#, Shao-Ping Li, Jing Zhao*, Chuang-Chuang Li*. Recent advances in total syntheses of natural products containing the benzocycloheptane motif.Nat. Prod. Rep.2021, 38, 1821-1851. (IF = 15.111)

 (3) Ya-Jian Hu#, Li-Xuan Li#, Jing-Chun Han#, Long Min#, Chuang-Chuang Li*. Recent Advances in the Total Synthesis of Natural Products Containing Eight-Membered Carbocycles (2009–2019).Chem. Rev.2020, 120, 5910-5953. (IF = 60.622)

 (4) Long Min#, Ya-Jian Hu#, Jian-Hong Fan#,Wen Zhang#,Chuang-Chuang Li*. Synthetic applications of type II intramolecular cycloadditions.Chem. Soc. Rev.2020, 49, 7015-7043. (IF = 54.564)

 (5) Jian-Hong Fan#, Ya-Jian Hu#, Qiang Guo, Shaoping Li, Jing Zhao*, Chuang-Chuang Li*. Asymmetric synthesis of the tetracyclic core of bufogargarizin C by an intramolecular [5+ 2] cycloaddition.Org. Chem. Front.2019, 6, 22-26. (IF = 5.155)

 (6) Ya-Jian Hu#, Jian-Hong Fan#, Shaoping Li, Jing Zhao*, Chuang-Chuang Li*. Synthetic Study toward the Total Synthesis of Taxezopidines A and B.Org. Lett.2018, 20, 5905-5909. (IF = 6.555)

 (7) Xin Liu#, Ya-Jian Hu#, Jian-Hong Fan#,Jing Zhao*, Shaoping Li*, Chuang-Chuang Li*. Recent synthetic studies toward natural products via [5+2] cycloaddition reactions.Org. Chem. Front.2018, 5, 1217-1228. (IF = 5.076)

 (8) Xin Liu#, Ya-Jian Hu#, Bo Chen#, Long Min, Xiao-Shui Peng, Jing Zhao*, Shaoping Li*, Henry N. C. Wong, Chuang-Chuang Li*. Asymmetric Total Syntheses of Colchicine, β-Lumicolchicine, and Allocolchicinoid N-Acetylcolchinol-O-methyl Ether (NCME).Org. Lett.2017, 19, 4612-4615. (IF = 6.492)

 (9) Ya-Jian Hu, Xiao-Bing Wang*, Su-Yi Li, Sai-Sai Xie, Kelvin D. G. Wang, Ling-Yi Kong*. Facile synthesis of spiro chromanone-tetrahydrothiophenes with three contiguous stereocenters via sulfa-Michael/aldol cascade reactions.Tetrahedron Lett.2015, 56, 105-108. (IF = 2.347)

 (10) Ya-Jian Hu, Neng Jiang, Sai-Sai Xie, Su-Yi Li, Jin-Shuai Lan, Ling-Yi Kong*, Xiao-Bing Wang*. Iodine-promoted sequential Michael and oxidative dehydrogenation processes: synthesis of trisubstituted methanes containing a coumarin and a chromone ring.Tetrahedron2015, 71, 8026-8032. (IF = 2.645)


6.联系方式

邮箱:yajianhu@jnu.edu.cn

地址:暨南大学第二理工楼617