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李小云

发布时间:2022-05-08 发布单位:药学院

1、个人简介:

李小云医学博士助理研究员20156月毕业于湖南中医药大学药学专业,获学士学位;20186获暨南大学中药学专业硕士学位,并于2017-2018年前往美国圣约翰大学进行访问学习20216月获暨南大学中西医结合临床专业博士学位;20219月入职暨南大学药学院。长期从事骨代谢疾病的中医药防治研究,主持暨南大学中央高校基本科研业务费项目1项,以(共)第一通讯作者在Frontiers in Cell and Developmental BiologyMolecular Nutrition and Food Research等杂志发表SCI论文7篇,申请国家专利1项,担任广东省中医药学会骨质疏松专业委员会委员。

2、研究方向:

(1) 骨代谢疾病的生理病理机制

(2) 中药药理及其靶点研究

3、主要学术兼职:

(1) 担任广东省中医药学会骨质疏松专业委员会委员

4、代表性科研项目:

(1) 暨南大学中央高校基本科研业务费项目21622329),基于外泌体miR-330-5p/SIRT6探讨补肾中药改善骨质疏松大鼠骨衰老的机制研究(2022.1.1-2023.12.319万元

5、代表性论文和专著:

(1) Xiaoyun Li,Qing Lin, Yan Cui, Haoyu Wang, panpan Wang, Li Yang, Qianyun Ye, Ronghua Zhang, Xiaofeng Zhu. Glycine Acts Through Estrogen Receptor Alpha to Mediate Estrogen Receptor Signaling, Stimulating Osteogenesis and Attenuating Adipogenesis in Ovariectomized Rats, Molecular Nutrition and Food Research, 2022, e2100857

(2) Xiaoyun Li, rumeng chen, Yunchuan Li, Panpan Wang, Yan cui, et al. miR-27a-5p—Abundant Small Extracellular Vesicles Derived From Epimedium-Preconditioned Bone Mesenchymal Stem Cells Stimulate Osteogenesis by Targeting Atg4B-Mediated Autophagy, Frontiers in Cell and Developmental Biology, 2021,9:642646

(3) Xiaoyun Li, Yan Cui, Qing Lin, et al. miR-330–5p in Small Extracellular Vesicles Derived From Plastrum testudinis-Preconditioned Bone Mesenchymal Stem Cells Attenuates Osteogenesis by Modulating Wnt/β-Catenin Signaling, Frontiers in Molecular Biosciences, 2021, 8:679345

(4) Xiaoyun Li,Bojia Peng, Zhu Xiaofeng, Wang Panpan, Kehuan Sun, Xiaotong Lei, Haibin He, Ya Tian, Shu Mo, Ronghua Zhang, Li Yang. MiR-210-3p inhibits osteogenic differentiation and promotes adipogenic differentiation correlated with Wnt signaling in ERα-deficient rBMSCs [J]. Journal of Cellular Physiology, 2019, 234(12): 23475-23484.

(5) Xiaoyun Li, Rumeng Chen , Xiaotong Lei ,Panpan Wang , Xiaofeng Zhu,, Ronghua Zhang b,*, Li Yang. Quercetin regulates ERα mediated differentiation of BMSCs through circular RNA, Gene, 2021, 769,145172

(6) Xiaoyun Li, Bojia Peng, Zhu Xiaofeng, Wang Panpan, Xiong Yingquan, Liu Hengrui, Sun Kehuan, Wang Haixia, Ou Ling, Ronghua Zhang, Li Yang. Changes related circular RNAs following ERbeta knockdown and the relationship to rBMSCs osteogenic [J].Biochemical and Biophysical Research Communications, 2017, 493(1):100-107.

(7) Xiaoyun Li, Bojia Peng, Yanbin Pan, Haibin He, Wang Panpan, Sun Kehuan, Lei Xiaotong, Ronghua Zhang, Li Yang. Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling [J]. Molecular Medicine Reports, 2018, 18(3):3483-3489.

(8) Lei Zhang, Yidong Li, Qianchao Wang ,Zhuo Chen,Xiaoyun Li, ZhuoXun Wu, Chaohua Hu, Dan Liao, Wei Zhang, Zhesheng Chen. The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer, Molecular Cancer, 2020, 19(1): 10

6、联系方式:

联系电话:020-85226213

联系邮箱:lxy21@jnu.edu.cn