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胡利军

发布时间:2021-04-06 发布单位:药学院


胡利军,理学博士,副研究员。2018年毕业于中国药科大学天然药物化学专业,获博士学位,导师为叶文才教授。在硕博连读期间,先后于北京大学深圳研究生院和南方科技大学李闯创教授课题组从事天然产物全合成研究工作。2020于暨南大学中药学博士后流动站完成博士后研究工作。目前,已申请获得主持国家自然科学基金青年基金、广东省自然科学基金面上项目和中国博士后科学基金面上项目各1项。已申请中国发明专利3项,其中已授权1项。已在Organic LettersOrganic Chemistry FrontiersChemistry A European Journal等本专业领域A1期刊上发表SCI论文13篇,其中以第一作者或共同第一作者发表A1期刊论文6篇。

主要研究方向

天然生物活性分子的全合成及结构修饰研究

近五年主持的科研项目

1. 国家自然科学基金青年基金项目:具促神经分化活性的一叶萩碱型生物碱衍生物的设计合成及其构效关系和作用机制研究(81903493)2019.01-2022.1221万元,在研,主持。

2. 中国博士后科学基金-面上项目:一叶萩碱型生物碱衍生物的设计合成和神经分化活性研究(2019M663404)2019.11-2021.88万元,已结题,主持。

3. 广东省自然科学基金-面上项目:具促神经分化功能的一叶萩碱型生物碱衍生物的设计合成及其构效关系和作用机制研究(2019A1515011478)2019.10-2022.0910万元,在研,主持。

近五年发表的论文

1. L. M. Deng #,L. J. Hu#, Y. T. Z. Bai, J. Wang, G. Q. Qin, Q. Y. Song, J. C. Su, X. J. Huang, R. W. Jiang, W. Tang, Y. L. Li, C. C. Li*, W. C. Ye*, Y. Wang*. Rhodomentosones A and B: two pairs of enantiomeric phloroglucinol trimers from Rhodomyrtus tomentosa and their asymmetric biomimetic synthesis, Organic Letters, 2021, 23: 4499–4504. (共同第一)

2. L. M. Deng #, L. J. Hu#, W. Tang #, J. X. Liu, X. J. Huang, Y. Y. Li, Y. L. Li, W. C. Ye*, Y. Wang*. A biomimetic synthesis-enabled stereochemical assignment of rhodotomentones A and B, two unusual caryophyllene-derived meroterpenoids from Rhodomyrtus tomentosa, Organic Chemistry Frontiers, 2021, 8: 5728–5735. (共同第一)

3. Q. F. He, Z. L. Wu, L. R. Li, W. Y. Sun, G. Y. Wang, R. W. Jiang, L. J. Hu, L. Shi, R. R. He, Y. Wang*, W. C. Ye*. Discovery of neuritogenic securinega alkaloids from Flueggea suffruticosa by a building blocks-based molecular network strategy, Angewandte Chemie International Edition, 2021, 60: 19609–19613.

4. Z. L. Wu#, X. J. Huang#, L. J. Hu#, W. Y. Zhang, Q. J. Xie, R. W. Jiang, Y. Wang*, W. C. Ye*. Absolute configurations and stereochemical inversion mechanism of epimeric Securinega alkaloids from Flueggea suffruticosa. Organic Letters, 2020, 22, 3673−3678. (共同第一)

5. S. L. Luo#, L. J. Hu#, X. J. Huang, J. C. Su, X. H. Shao, L. Wang, H. L. Xu, C. C. Li*, Y. Wang*, W. C. Ye*. Discovery and biomimetic synthesis of a phloroglucinol-terpene adduct collection from Baeckea frutescens and its biogenetic origin insight, Chemistry A European Journal, 2020, 49, 11104−11108. (共同第一)

6. J. He#, L. J. Hu#, X. J. Huang, C. R. Wang, Z. M. Zhang, Y. Wang, D. M. Zhang*, W. C. Ye*. Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors, International Journal of Antimicrobial Agents, 2020, 56, 106055. (共同第一)

7. J. H. Gu#, W. J. Wang#, J. Z. Chen, J. S. Liu, N. P. Li, M. J. Cheng, L. J. Hu, C. C. Li*, W. C. Ye*, L. Wang*. Leptosperols A and B, two cinnamoylphloroglucinol-sesquiterpenoid hybrids from Leptospermum scoparium: structural elucidation and biomimetic synthesis, Organic Letters, 2020, 22: 1796−1800.

8. W. Q. Yang#, X. H. Shao#, F. Deng,L. J. Hu, Y. Xiong, X. J. Huang, C. L Fan, R. W. Jiang, W. C. Ye*, Y. Wang*. Unprecedented quassinoids from Eurycoma longifolia: Biogenetic evidence and antifeedant effects, Journal of Natural Products, 2020, 83, 1674−1683.

9. L. J. Deng#, Y. Li#, M. Qi, J. S. Liu, S. Wang, L. J. Hu, Y. H. Lei, R. W. Jiang, W. M. Chen, Q. Qi, H. Y. Tian, W. L. Han, B. J. Wu, J. X. Chen, W. C. Ye*, D. M. Zhang*. Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment, European Journal of Pharmacology, 2020, 887: 173379.

10. J. G. Song#, J. C. Su#, Q. Y. Song, R. L. Huang, W. Tang,L. J. Hu, R. W. Jiang, Y. L. Li, W. C. Ye*, Y. Wang*. Cleistocaltones A and B, antiviral phloroglucinol-terpenoid adducts from Cleistocalyx operculatus, Organic Letters, 2019, 21: 9579−9583.

11. J. Zhang, Z. W. Liu, Y. L. Ao, L. J. Hu, C. J. Wei, Q. H Zhang, M. F. Yuan, Y. Wang, Q. W. Zhang*, W. C. Ye*, X. Q. Zhang*. Hunterines A and C, three unusual monoterpenoid indole alkaloids from Hunteria zeylanica, The Journal of Organic Chemistry, 2019, 84: 14892−14897.

12. L. J. Hu#, M. J. Cheng#, J. Q. Cao, L. P. Zhong, Y. J. Hu, Y. Wang, L. Wang*, W. C. Ye*, C. C. Li*. Asymmetric total syntheses of callistrilones B, G and J [J]. Organic Chemistry Frontiers, 2018, 5: 1506−1510.

13. M. J. Cheng, J. Q. Cao, X. Y. Yang, L. P. Zhong, L. J. Hu, X. Lu, B. L. Hou, Y. J. Hu, Y. Wang, X. F. You, L. Wang*, W. C. Ye*, C. C. Li*. Catalytic asymmetric total syntheses of myrtucommuacetalone, myrtucommuacetalone B and callistrilones A, C, D and E [J]. Chemical Science, 2018, 9: 1488−1495.

 


联系方式

邮箱:hulj2018@jnu.edu.cn