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张雪娟

发布时间:2022-07-12 发布单位:药学院

      张雪娟,女,博士,副教授,硕士生导师,暨南大学“青蓝学者”。博士后合作导师为吴传斌教授。2020年毕业于广东工业大学生物医药学院,获工学博士学位,导师为国家特聘专家吴传斌教授和谭文教授。2017年毕业于中山大学药学院药学专业,并获理学硕士学位;2014年毕业于广州中医药大学中药学,获理学学士学位。本人专业方向为药剂学,主要从事新型药物制剂的基础和应用转化研究。近年来主持各级科研项目3项,其中国家自然科学基金项目1项。在国际及国内重要刊物发表论文30余篇,公开申请专利3项,获授权发明专利4项。


      研究方向

      肺部药物递送系统

      吸入制剂工业转化

      口鼻吸入制剂的递送机理研究

      鼻-脑药物递送系统


      代表性科研项目

1.国家自然科学基金青年基金项目(82104072),基于模块化实时监控平台探究吸入粉雾剂载体对肺部药物递送过程的影响机制(20221-202412月,30.0万元,主持)

2.广州市基础研究计划基础与应用基础研究项目(202201010424),吸入粉雾剂肺部药物递送过程及影响机制的剖析及其用于处方快速筛选的研究(202204-202403月,5万元,主持)

3.暨南大学中央高校基本科研业务费项目(2162014),吸入粉雾剂载体对肺部药物递送过程研究:模块化实时监控平台的构建与应用(202101-202212月,9万元,主持)

4.广东省重点领域研发计划项目——广东省防治新型冠状病毒科技攻关专项(2021B1111110004),抗新型冠状病毒候选药物HNT-5的研发(202111-202210月,200万,参与)

5.广东省科技计划项目——粤澳科技联合资助项目(2021A0505080011),基于炔丙基半胱氨酸纳米粒与功能性糖载体修饰吸入粉雾剂技术的肺部给药治疗肺炎研究(20206-20226月,100万,参与)

6.国家自然科学基金面上项目(81673375),干粉吸入剂二元载体表面微结构的定向构建及其增效机理的研究(20181-202012月,20.1万元,参与)。


代表性著作

1.Y. Cui†, Y. Huang†,X. Zhang*, X. Pan*, X. LuJ. Xue, G. Wang, P. Hu, X. Yue, Z. Zhao, X.  Pan*, C. Wu. A Real-time and Modular Approach for Quick Detection and Mechanism Exploration of DPIs with Different Carrier Particle Sizes. Acta Pharm Sin B. 2022, 12(1): 437-450. (IF = 14.903)

2.X. Zhang , Y. Cui †, R. Liang, G. Wang, X. Yue, Z. Zhao, Z. Huang, Y. Huang*, J. Geng, X. Pan*, C. Wu. Novel Approach for Real-Time Monitoring the Delivery Process of Carrier-Based DPIs via Pulmonary Route Based on Modular Modified Sympatec Helos. Acta Pharm Sin B. 2020, 10(7): 1331-1346. (IF = 14.903)

3.X. Yue†,X. Zhang†, C. Wang, Y. Huang*, P. Hu, G. Wang, Y. Cui, X. Xia, Z. Zhou, X. Pan*, C. Wu. A bacteria-resistant and self-healing spray dressing based on lyotropic liquid crystals to treat infected post-operative wounds. J Mater Chem B. 2021, 9(38): 8121-8137. (IF = 7.571,)

4.X. Zhang, Y. Xiao, Z. Huang, J. Chen, Y. Cui, B. Niu, Y. Huang*, X. Pan*, C. Wu. Smart phase transformation system based on lyotropic liquid crystalline@ hard capsules for sustained release of hydrophilic and hydrophobic drugs. Drug Deliv. 2020, 27(1): 449-459. (IF = 6.891)

5.X. Zhang, Y. Zhou, G. Wang, Z. Zhao, Z. Jiang, Y. Cui, X. Yue, Z. Huang*, Y. Huang*, X. Pan, C. Wu. Co-Spray-Dried Poly-L-lysine with L-Leucine as Dry Powder Inhalations for the Treatment of Pulmonary Infection: Moisture-Resistance and Desirable Aerosolization Performance.Int J Pharmaceut. 2022. (IF = 6.51)

6.Y. Cui†,X. Zhang, W. Wang, Z. Huang, Z. Zhao, G. Wang, S. Cai, H. Jing, Y. Huang*, X. Pan, C. Wu*. Moisture-resistant co-spray-dried netilmicin with L-leucine as dry powder inhalation for the treatment of respiratory infections. Pharmaceutics. 2018; 10(252): 1-13. (IF=6.525)

7.X. Zhang, Z. Zhao, Y. Cui, F. Liu, Z. Huang, Y. Huang*, R. Zhang, T. Freeman, X. Lu, X. Pan, W. Tan, C. Wu*. Effect of powder properties on the aerosolization performance of nanoporous mannitol particles as dry powder inhalation carriers. Powder Technol.2019, 358: 46-54. (IF=5.64)

8.Z. Zhao†,X. Zhang, Y. Cui, Y. Huang*, Z. Huang, G. Wang, R. Liang, X. Pan, L. Tao, C. Wu*. Hydroxypropyl-β-cyclodextrin as anti-hygroscopicity agent inamorphous lactose carriers for dry powder inhalers. Powder Technol.2019, 358: 29-38. (IF=5.64)

9.X. Zhang, Y. Li, Z. Huang, Y. Cui, Z. Zhao, X. Yue, G. Wang, R. Liang, Y. Huang*, W. Tan, C.Wu*. Development and pharmacokinetics evaluation of quetiapine fumarate sustained-release tablets based on hydrophilic matrix. J Drug Deliv Sci Tec. 2019, 54: 101322. (IF = 5.062,)

10.T. Peng†,X. Zhang, Y. Huang, Z. Zhao, Q. Liao, J. Xu, Z. Huang, J. Zhang, C. Wu, X. Pan*, C. Wu*. Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the aerosolization performance for dry powder inhalation. Sci Rep. 2017; 7. (IF=4.996)


主要专利情况

1.吴传斌,张雪娟,赵紫玉。多孔结构的载体颗粒及其制备方法和应用,中国:201611124085.X,授权

2.吴传斌,赵紫玉,张雪娟。防潮抗湿的低密度载体颗粒及其制备方法和应用,中国:201611185899.4,授权

3.李革,赵紫玉,张雪娟。低密度的无定形载体颗粒及其制备方法和应用,中国:201611235511.7,授权

4.潘昕,黄莹,彭婷婷,张雪娟。表面纳米级粗糙结构的颗粒及其制备方法和应用,中国:201610013832.6授权

5.张雪娟,黄郑炜,黄莹,吴传斌,周钥,王冠林,翟紫照.硫酸多黏菌素B/棉子糖干粉及其吸入粉雾剂和制备方法.申请号: CN202210061115.6.公告公开日: 2022-06-14.

6.黄郑炜,张雪娟,吴传斌,潘昕,黄莹,付芳琴,白雪群,王文浩.用于吸入气雾剂的低制冷效应复合抛射剂及其制备方法和应用.申请号: CN2022101631104.公告公开日: 2022-05-24.

7.吴传斌,张雪娟,崔影彤,周钥,王冠林,潘昕,黄莹,黄郑炜,李峰,陈航平,冯地桑,许日龙. ε-聚赖氨酸干粉、ε-聚赖氨酸吸入粉雾剂及其制备方法.申请号: CN202111137953.9.公告公开日: 2021-12-10.

会议报告

1. 2021.04,中国上海:第五届中国吸入制剂工业研讨会.仿制型和改良型吸入制剂的研发策略

2. 2019.09,中国成都:2019第一届亚洲药剂学青年学者论坛. Poly-lysine Dry Powder Inhalations for the Effective Delivery and Accurate Treatment of Pulmonary Infection  

3. 2018.12,中国广州:2018第十二届中国药物制剂大会. In Vivo Lung Injury of Nanoporous Mannitol Carriers for Dry Powder Inhalation

4. 2018.06,中国广州:2018年第十三届AAPS中新亚洲药学论坛. Effect of Powder Properties on the Aerosolization Performance of Nanoporous Mannitol Particles as Dry Powder Inhalation Carriers

5. 2017.09,中国苏州:第三届全国生物颗粒学术研讨会暨全国第四届化工前沿(苏州)论坛. Insights into the Role of Carrier on the Dry Powder Inhalers Aerosolization Performance