您当前位置: 首页  师资队伍  教师名单  副教授

黄晓君

发布时间:2020-10-21 发布单位:药学院

黄晓君,理学博士,天然药物化学专业,副研究员、硕士生导师。20039月毕业于天津中医药大学中药学专业,获学士学位;20106月毕业于中国药科大学,获博士学位。2010720156月,先后完成暨南大学和澳门大学博士后研究工作,20157月正式入职暨南大学药学院工作,先后任讲师、副研究员。

一直从事中药和天然药物的活性成分研究工作,已先后从女贞子、黑水银莲花、林荫银莲花、何首乌等药用植物中分离并鉴定了包括裂环环烯醚萜及其苷类、三萜及皂苷、黄酮、二苯乙烯苷等多种结构类型的200余种天然产物,其中新化合物50余个,在天然药物化学研究领域具丰富的研究经验。近年来,工作重点逐渐聚焦于计算化学方法在药物化学研究领域中的应用,利用量子化学计算方法,完成60余个分属不同骨架类型的天然产物的绝对构型进行了研究,通过计算CDORNMR等方法确定了这些缺乏单晶数据、含量低、骨架结构新颖的化合物的绝对构型,为具类似骨架结构化合物的绝对构型的确定提供了参考。先后承担国家及省部级项目5项,参与国家级课题15项;已发表SCI收录论文104(第一作者或通讯作者论文18)


代表性论文:

  1. Wu ZL#, Huang XJ#, Hu LJ#, Zhang WY, Xie QJ, Jiang RW, Wang Y*, Ye WC*. Absolute configurations and stereochemical inversion mechanism of epimeric securinega alkaloids from Flueggea suffruticosa. Organic Letters, 2020, 22, 3673−3678.

  2. Wu ZL#, Huang XJ#, Xu MT, Ma X, Li L, Shi L, Wang WJ, Jiang RW, Ye WC*, Wang Y*. Flueggeacosines A–C, dimeric securinine-type alkaloid analogues with neuronal differentiation activity from Flueggea suffruticosa. Organic Letters, 2018, 20, 7703−7707.

  3. Jian YQ, Huang XJ#,, Zhang DM, Jiang RW, Chen MF, Zhao BX, Wang Y*, Ye WC*. Guapsidial A and guadials B and C: three new meroterpenoids with unusual skeletons from the leaves of Psidium guajava. Chemistry, a European Journal, 2015, 21, 9022−9027.

  4. Li SG#, Huang XJ#, Li MM, Liu Q, Liu H, Wang Y*, Ye WC*. Multiflorumisides A-G, dimeric stilbene glucosides with rare coupling patterns from the roots of Polygonum multiflorum. Journal of Natural Products, 2018, 81, 254−263.

  5. Zhang W#, Huang XJ#, Zhang SY, Zhang DM, Jiang RW, Hu JY, Zhang XQ, Wang L*, Ye WC*. Geleganidines A-C, unusual monoterpenoid indole alkaloids from Gelsemium elegans. Journal of Natural Products, 2015, 78, 2036−2044.

  6. Liu ZW #, Huang XJ #, Xiao H-L, Liu G, Zhang J, Shi L, Jiang R-W, Zhang XQ*, Ye WC*. New iboga-type alkaloids from Ervatamia hainanensis. RSC Advanses, 2016, 6, 30277−30284.

  7. Huang XJ#, Wang L#, Shao M, Hu SZ, Jiang RW, Yao XS, Li YL, Yin ZQ*, Wang Y*, Ye WC*. Oleonin, the first secoiridoid with 1α-configuration from Ligustrum lucidum. RSC Advances, 2013, 3, 16300−16303.

  8. Huang XJ#, Li P#, Yin ZQ, Lu JJ, Lin LG, Wang Y, Ye WC, Zhang QW*. Cablinosides A and B, two glycosidic phenylacetic acid derivatives from the leaves of Pogostemon cablin. Chemistry & Biodiversity, 2019, 16, e1900137.

  9. Huang XJ#, Wen S#, Wu ZL, Guan XF, Li MM, Fan CL, Zhang QW, Chan G, Wang Y*, Ye W-C*. Eleven new triterpenoid glycosides from the roots of Ilex asprella. Chemistry & Biodiversity, 2019, 16, e1900202.

  10. Li SG#, Huang XJ#, Zhong YL, Li MM, Li YL, Wang Y*, Ye WC*. Stilbene glycoside oligomers from the roots of Polygonum multiflorum. Chemistry & Biodiversity, 2019, 16, e1900192.

  11. Huang XJ#, Tang JQ, Li MM, Liu Q, Li YL, Fan CL, Pei H, Zhao HN, Wang Y*, Ye WC*. Triterpenoid saponins from the rhizomes of Anemone flaccida and their inhibitory activities on LPS-induced NO production in Macrophage RAW264.7 cells. Journal of Asian Natural Products Research, 2014, 16, 910−921.

  12. Chen LL#, Huang XJ#, Li MM, Ou GM, Zhao BX, Chen MF, Zhang QW, Wang Y*, Ye W-C*. Polygonflavanol A, a novel flavonostilbene glycoside from the roots of Polygonum multiflorum. Phytochemistry Letters, 2012, 5, 756−760.


联系方式:

地址:暨南大学第二理工楼609

电话:020-85227821

邮箱:zhyxiaohuang********