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张志民

发布时间:2022-05-08 发布单位:药学院

1、个人简介:

张志民,理学博士,研究员,博士生导师。20036月本科毕业于中南大学材料科学与工程专业;20126月获得中科院上海有机化学研究所博士学位;同年赴加州大学河滨分校(UCR)从事博士后研究。20178月入职暨南大学药学院生物制药系。长期以具有重要生理功能和新颖催化机制的化学修饰酶为研究对象,致力于酶的结构生物与结构药理学研究。近年来以(共)第一/(共)通讯作者在NatureNature PlantsNature Structural & Molecular BiologyNature CommunicationsAngew. Chem.J. Med. Chem.等国际知名期刊发表研究论文多篇。2019年入选广东省“珠江人才”计划青年拔尖人才。

2、研究方向:

(1)潜在药物靶标的作用机制研究

(2)酶催化药物分子的生物合成机制

(3)药物与靶蛋白作用机制研究

3、代表性科研项目:

(1) 国家自然科学基金面上项目(32171184),植酸InsP6激活YopJ家族效应蛋白的分子机制研究(20221-202512月,58

(2)国家自然科学基金青年项目(31800638),鼠疫杆菌效应蛋白YopJMAPK激酶作用机制的研究(20191-202112月,28万)

(3) 广东省自然科学基金面上项目(2022A1515012266),T7分泌系统免疫因子抑制毒蛋白活性的作用机制研究(20221-202412月,10

(4)广东省自然科学基金自由申请项目(2018A030313003),鼠疫杆菌效应蛋白YopJMAPK激酶作用机制的研究(20185-20214月,10万)

(5)广州市科技厅市校联合项目(202102010044),DNA甲基转移酶多酚类小分子抑制剂的作用机制研究20214-20243月,20万)

4、近年主要代表性论文:

(1)Peng Chen#, Jie Sun#, Chengjun Zhu#, Guanghui Tang*, Wei Wang, Manyi Xu, Menghua Xiang, ChongJing Zhang, Zhi-Min Zhang*, Liqian Gao*, Shao Q Yao*. Cell-Active, Reversible, and Irreversible Covalent Inhibitors that Selectively Target the Catalytic Lysine of BCR-ABL Kinase, Angew. Chem. Int. Ed., 2022, doi: 10.1002/anie.202203878

(2)Yao Xia#, Rongfeng Zou#, Maxime Escouboué#, Liang Zhong#, Chengjun Zhu, Cécile Pouzet, Xueqiang Wu, Yongjin Wang, Guohua Lv, Haibo Zhou, Pinghua Sun*, Ke Ding*, Laurent Deslandes*, Shuguang Yuan*, Zhi-Min Zhang*. Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase, Nat. Commun., 2021, 12: 5969.

(3)Zexing Wen#, Zhi-Min Zhang#, Liang Zhong#, Jiaqian Fan, Min Li, Yuanhong Ma, Yang Zhou, Wei Zhang, Bin Guo, Bo Chen, and Jian-Bo Wang. Directed Evolution of a Plant Glycosyltransferase for Chemo- and Regioselective Glycosylation of Pharmaceutically Significant Flavonoids, ACS Catalysis, 2021, doi: 10.1021/acscatal. 1c04191

(4)Yue-Hong Zhang#, Yi-Fang Li#, Yongjin Wang#, Li Tan, Zhi-Qin Cao, Chao Xie, Guo Xie, Hai-Biao Gong, Wan-Yang Sun, Shu-Hua Ouyang, Wen-Jun Duan, Xiao yun Lu, Ke Ding, Hiroshi Kurihara, Dan Hu*, Zhi-Min Zhang*, Ikuro Abe*, and Rong-Rong He*. Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in teaNat. Commun., 2020, 11: 1473.

(5)Zhi-Min Zhang#, Rui Lu#, Pengcheng Wang, Yang Yu, Dongliang Chen, LinfengGao, Shuo Liu, DebinJi, Scott B Rothbart, Yinsheng Wang, Gang Greg Wang*&Jikui Song*. Structural basis for DNMT3A-mediated de novo DNA methylation, Nature, 2018, 554(7692): 387-391

(6)Zhi-Min Zhang#, Ka-Wai Ma#, Linfeng Gao#, Zhenquan Hu, Simon Schwizer, Wenbo Ma*, and Jikui Song*. Mechanism of Host Substrate Acetylation by a Yopj Family Effector,  Nat. Plants, 2017, 3:17115.

(7)Zhi-Min Zhang#, Ka-Wai Ma#, Shuguang Yuan, Youfu Luo, Shushu Jiang, Eva Hawara, Songqin Pan, Wenbo Ma*, Jikui Song*. Structure of a pathogen effector reveals enzymatic mechanism of a novel acetyltransferase family, Nat. Struct & Mol. Biol., 2016, 23(9):847-852.

(8)Zuqin Wang#, Jie Wang#, Yongjin Wang#, Shuang Xiang, Xiaojuan Song, Zhengchao Tu, Yang Zhou, Zhi-Min Zhang*, Zhang Zhang*, Ke Ding*, Xiaoyun Lu*. Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance, J. Med. Chem., 2022, doi:10.1021/acs.jmedchem.2c00308

(9)Youlong Fan#, Hongfei Si#, Zhang Zhang, Liang Zhong, Hongyan Sun, Chengjun Zhu, Zhibin Yin, Huilin Li, Guanghui Tang, Shao Q Yao, Pinghua Sun*, Zhi-Min Zhang*, Ke Ding*, Zhengqiu Li*. Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery, J. Med. Chem., 2021, doi: 10.1021/acs.jmedchem.0c02024

(10)Minhao Huang#, Yongjun Huang#, Jing Guo#, Lei Yua, Yu Chang, Xiaolu Wang, Jinfeng Luo, Yanhui Huang, Zhengchao Tu, Xiaoyun Lu, Yong Xu, Zhimin Zhang*, Zhang Zhang*, Ke Ding*. Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors, Eur.J. Med. Chem., 2020, 211: 113023

5、联系方式:

联系电话:13632107756

邮箱:zhangzm@jnu.edu.cn