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林静
发布时间:2017-05-31

 

   林静,女,理学博士,副教授,硕士生导师。

2008年毕业于华中师范大学化学生物学基地班,获化学、生物技术学双学位。同年保送入中山大学药物化学专业,硕博连读;2013年获理学博士学位;同年进入暨南大学药学院任教,讲授本科生《药物化学》及《药物化学实验》等课程。

一直从事药物分子设计、评价及机制研究工作。曾获教育部学术新人奖。目前发表SCI论文21篇,其中以第一作者及通讯作者在Nucleic Acids Res.J. Med. Chem.Biomacromolecules等杂志发表SCI论文13篇。主持国家自然科学基金青年基金项目、广东省教育厅青年创新人才项目、暨南大学科研培育与创新基金青年基金项目、暨南大学教学改革研究项目(实践教学专项)1项,申请发明专利1项。 

 

研究方向:

1.细菌群体感应和细菌生物膜抑制剂的发现与机制研究

2.新型核酸靶向性抗感染药物研究

 

代表性论文:

1.Chan Shan1, Jing Lin1, Jin-Qiang Hou, Shuo-Bin Chen, Ai-Chun Chen, Tian-Miao Ou*, Jia-Heng Tan, Ding Li, Lian-Quan Gu, Zhi-Shu Huang*, Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule, Nucleic Acids Research, 2015, 15(6): 744-754.

2.Tian-Miao Ou1, Jing Lin1, Lu Yu-Jing, Jin-Qiang Hou, Jia-Heng Tan, Shu- Han Chen, Zeng Li, Yan-Ping Li, Ding Li, Lian-Quan Gu*, Zhi-Shu Huang*. Inhibition of Cell Proliferation by Quindoline Derivative SYUIQ-05 through its Preferential Interaction with c-myc Promoter G-Quadruplex. Journal of Medicinal Chemistry, 2011, 54: 5671-5679.

3.Jing Lin, Yi-Yong Yan, Tian-Miao Ou, Jia-Heng Tan, Shi-Liang Huang, Ding Li, Zhi-Shu Huang*, and Lian-Quan Gu*. Effective Detection and Separation Method for G-Quadruplex DNA Based on Its Specific Precipitation with Mg2+. Biomacromolecules, 2010, 11: 3384-3389.

4.Jing Lin, Jin-Qiang Hou, Han-Dan Xiang, Yi-Yong Yan, Yu-Chao Gu, Jia-Heng Tan, Ding Li, Lian-Quan Gu, Tian-Miao Ou*, Zhi-Shu Huang*, Stabilization of G-Quadruplex DNA by C-5-Methyl-Cytosine in bcl-2 Promoter: Implications for Epigenetic Regulation, Biochemical and Biophysical Research Communications, 2013, 433: 368-373.

5.Fang Wang, Jing Lin*, Wen Hou, Mei-Yan Huang, Ping-Hua Sun, Wei-Min Chen*, 5-Benzylidene-3,4-dihalo-furan-2-one derivatives inhibit human leukemia cancer cells through suppression of NF-kB and GSK-3β, Anti-cancer agents in medicinal chemistry, 2015, 15(6): 744-754.

6.Zhi-Zhong Geng1, Jian-Jun Zhang1, Jing Lin*, Mei-Yan Huang , Lin-Kun An , Hong-Bin Zhang , Ping-Hua Sun, Wen-Cai Ye , Wei-Min Che*, Novel cajaninstilbene acid derivatives as antibacterial agentsEuropean Journal of Medicinal Chemistry, 2015, 100: 235-245.

7.Mei-Yan Huang1, Jing Lin1, Kuo Lu, Hong-Gui Xu, Zhi-Zhong Geng, Ping-Hua Sun, and Wei-Min Chen*, Anti-Inflammatory Effects of Cajaninstilbene Acid and Its Derivatives, Journal of Agricultural and Food Chemistry, 2016, 64: 2893-2900.

8.Wen Hou, Zhen-Ya Wang, Cheng-Kang Peng, Jing Lin*, Xin Liu, Yi-Qun Chang, Jun Xu, Ren-Wang Jiang, Hui Lin, Ping-Hua Sun, Wei-Min Chen*, Novel securinine derivatives as topoisomerase I based antitumor agents, European Journal of Medicinal Chemistry, 2016, 122: 149-163.

9.Cheng-Kang Peng1, Ting Zeng1, Xing-Jun Xu, Yi-Qun Chang, Wen Hou, Kuo Lu, Hui Lin, Ping-Hua Sun, Jing Lin*, Wei-Min Chen*, Novel 4-(4-substituted amidobenzyl)furan-2(5H)-one derivatives as topoisomerase I inhibitors, European Journal of Medicinal Chemistry, 2017, 127: 187-199.

10.Wen Hou, Hui Lin, Zhen-Ya Wang, Martin G. Banwell, Ting Zeng, Ping-Hua Sun, Jing Lin* and Wei-Min Chen*, Novel bivalent securinine mimetics as topoisomerase I inhibitors, MedChemComm, 2017, 8: 320-328.

 

*通讯作者  1并列第一作者

 

联系方式

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