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陈卫民
发布时间:2014-07-18

陈卫民,男,教授,博士,博士生导师。现任暨南大学药学院副院长。主要从事药物合成和新药研究工作,已承担多项国家自然科学基金、省市基金等科研项目,承担和参与了多个新药品种的研制,获国家新药证书5(包括原料药与制剂),曾获军队科技进步奖4项、广东省科技进步奖2项。在国内外学术期刊上发表学术论100余篇,其中SCI收录50余篇。科研兴趣包括细菌群体感应和细菌生物膜抑制剂的设计与合成;新型抗生素与抗感染药物的合成;天然活性化合物的结构修饰与构效关系研究;以及计算机辅助药物设计等。目前从事药物化学的教学与科研工作,讲授本科生《药物化学》、研究生《高等有机化学》等课程。

现为暨南大学药物化学专业硕士研究生指导教师,中药化学专业博士生指导教师。已毕业硕士和博士研究生42人,在读博士生3人,硕士生9人。在已毕业的研究生中,大部分在国内医药企业或高等学校工作并成长为业务骨干。

 

学习经历

1979.9-1983.7  华中工学院(现华中科技大学),理学学士

1987.9-1990.6  同济医科大学,医学硕士

1995.9-1998.12 中山大学,理学博士

2001.6-2003.6  香港中文大学,Research Associate

工作经历

   1983.8-1990.5  石家庄陆军学院, 教师

   1990.6-2004. 6 第一军医大学, 讲师、副教授、教授

   2004.7-       暨南大学, 教授

 

 

主要研究方向

1.       新型抗感染药物的设计与合成;

2.       天然活性化合物的结构修饰与活性先导物发现。

 

近五年承担的主要科研项目:

 

1.     广东省自然科学基金重点项目(2014A030311021), 以木豆素为先导化合物的新型抗菌药物的设计与合成,30万元,2014/10-2016/09,在研,项目负责人;

2.     国家自然科学基金(81273362):一叶萩型生物碱二聚体的仿生合成及其抗肿瘤作用研究,70万,2013/01-2016/12项目负责人;

3.     国家自然科学基金(81072554):基于铜绿假单胞菌生物膜耐药及感染机制的新药设计与合成,35万,2011/01-2013/12,项目负责人;

4.     广东省自然科学基金(S2012010008130):基于沙蟾毒精结构优化的新型抗肿瘤药物设计与合成,5万,2012/10-2014/10,项目负责人

5.     国家自然科学基金-广东省联合基金(U0932004):基于GABA受体靶标的新型一叶萩型生物碱的发现及其构效关系和作用机制研究,200万,2010/01-2013/12,核心成员(排名第三,负责结构修饰研究,子课题负责人);

6.     教育部高等学校博士学科点专项科研基金(20124401110008):基于沙蟾毒精结构优化的新型抗肿瘤药物设计与合成,12万元,2013/01-2015/12,项目负责人。

 

近五年代表性论文:

 

1.        Huang, Mei-Yan(#); Lin, Jing(#); Huang, Zhi-Jian; Xu, Hong-Gui; Hong, Juan; Sun, Ping-Hua; Guo, Jia-Liang; Chen, Wei-Min(*). Design, synthesis and anti-inflammatory effects of novel 9-O-substituted-berberine derivatives, Med. Chem. Commun., 2016, DOI: 10.1039/c5md00577a.

2.        Zhang, Dong-Mei(#); Xu, Hong-Gui(#); Wang, Lei; Li, Ying-Jie; Sun, Ping-Hua; Wu, Xiao-Ming; Wang, Guang-Ji; Chen, Wei-Min(*); Ye, Wen-Cai(*). Betulinic Acid and its Derivatives as Potential Antitumor AgentsMedicinal Research Reviews2015356):1127-1155.

3.        Chen, Yan(#); Ruan, Zhi-Xiong(#); Wang, Fang; Huangfu, De-Sheng; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min(*). Novel Oxazolidinone Antibacterial Analogues with a Substituted Ligustrazine C-ring UnitChemical Biology & Drug Design2015864):682-690.

4.        Li, Zhiqiang; Li, Qingjiang; Liu, Guo-Kai; Chen, Weimin(*); Peng, Xiao-Shui; Wong, Henry N. C.(*). Gold(I)-Catalyzed Domino Cyclization for the Synthesis of Tricyclic ChromonesSynlett20152611):1461-1464

5.        Wang, Fang; Lin, Jing(*);Hou, Wen; Huang, Mei-Yan; Sun, Ping-Hua; Chen, Wei-Min(*). 5-Benzylidene-3,4-dihalo-furan-2-one Derivatives Inhibit Human Leukemia Cancer Cells Through Suppression of NF-kappa B and GSK-3 betaAnti-Cancer Agents in Medicinal Chemistry2015156):744-754

6.        Geng, Zhi-Zhong(#); Zhang, Jian-Jun(#); Lin, Jing(*); Huang,Mei-Yan; An,Lin-Kun; Zhang,Hong-Bin; Sun,Ping-Hua; Ye,Wen-Cai; Chen, Wei-Min(*). Novel cajaninstilbene acid derivatives as antibacterial agents, European Journal of Medicinal Chemistry2015100:235-245.

7.        Hu, Yu-Quan; Li, Chen;Zhao, Bing-Xin;Li, Jun-Yong;Huang, Xiao-Jun;Lin, Jing; Wang, Ying; Ye, Wen-Cai(*); Chen, Wei-Min(*). Regioselective and stereoselective photodimerization of securinine-type and norsecurinine-type alkaloidsTetrahedron20147033):4903-4909.

8.        Wang, Fang; Sun, Jun-Rong; Huang, Mei-Yan; Wang, Hui-Ying; Sun, Ping-Hua; Lin, Jing; Chen, Wei-Min(*). Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivativesEuropean Journal of Medicinal Chemistry20147235-45.

9.        Shan, Ling-Xing; Sun, Ping-Hua(*); Guo, Bao-Qin; Xu, Xing-Jun; Li, Zhi-Qiang; Sun, Jia-Zhi; Zhou,Shu-Feng; Chen, Wei-Min(*). Synthesis and antibacterial activities of acylide derivatives bearing an aryl-tetrazolyl chainDrug Design, Development and Therapy201481515-1525.

10.    Zhao, Bing-Xin; Wang, Ying; Li, Chen; Wang, Guo-Cai; Huang, Xiao-Jun; Fan, Chun-Lin; Li, Qing-Ming; Zhu,Hua-Jie(*); Chen, Wei-Min(*); Ye, Wen-Cai(*). Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosaTetrahedron Letters20135435):4708-4711.

11.    Ruan, Zhi-Xiong; Huangfu, De-Sheng; Sun, Ping-Hua(*); Chen, Wei-Min(*). Molecular modeling studies on 3,4-dihydroquinazolines as trypanothione reductase inhibitors using 3D-QSAR and docking approachesMedicinal Chemistry Research2013228):3541-3555.

12.    Jia, Fei; Hong, Juan; Sun, Ping-Hua; Chen, Jian-Xin; Chen, Wei-Min(*). Facile Synthesis of the Neuraminidase Inhibitor PeramivirSynthetic Communications20134319):2641-2647.

13.    Liu, Junshan; Zhang, Dongmei; Li, Yuan; Chen, Weimin; Ruan, Zhixiong; Deng, Lijuan; Wang, Liwei; Tian,Haiyan; Yiu, Anita; Fan, Chunlin; Luo, Hai; Liu, Shanwen; Wang, Ying; Xiao, Gaokeng; Chen, Lixin; Ye,Wencai(*). Discovery of Bufadienolides as a Novel Class of ClC-3 Chloride Channel Activators with Antitumor ActivitiesJournal of Medicinal Chemistry20135614):5734-5743.

14.    Ruan, Zhi-Xiong; Huangfu, De-Sheng; Xu, Xing-Jun; Sun, Ping-Hua; Chen, Wei-Min(*). 3D-QSAR and molecular docking for the discovery of ketolide derivativesExpert Opinion on Drug Discovery201384):427-444.

15.    Zhang, Dong-Mei; Li, Ying-Jie; Shu, Chang; Ruan, Zhi-Xiong; Chen, Wei-Min; Yiu, Anita; Peng,Ying-Hui; Wang, Jiao; Lan, Ping; Yao, Zhe; Fung, Kwok-Pui; Fu, Li-Wu; Chen, Zhe-Sheng; Ye, Wen-Cai(*). Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cellsAnti-Cancer Drugs2013245):441-454.

16.    Wang, Wen-Jing; Wang, Lei; Huang, Xiao-Jun; Jiang, Ren-Wang; Yang, Xiao-Lin; Zhang, Dong-Mei; Chen,Wei-Min; Tang, Ben-Qin; Wang, Ying; Zhang, Xiao-Qi; Ye, Wen-Cai(*).Two pairs of new benzofuran enantiomers with unusual skeletons from Eupatorium chinenseTetrahedron Letters20135426):3321-3324.

17.    Li, Jun-Yong; Zhao, Bing-Xin; Zhang, Wen; Li, Chen; Huang, Xiao-Jun; Wang, Ying(*); Sun, Ping-Hua; Ye,Wen-Cai; Chen, Wei-Min(*). Unexpected ring contraction and oxidation rearrangement reactions of securinineTetrahedron20126821):3972-3979.

18.    Liu, Guo-Yong; Guo, Bao-Qin; Chen, Wan-Na; Cheng, Chao; Zhang, Qian-Lan; Dai, Mi-Bei; Sun,Jun-Rong; Sun, Ping-Hua(*); Chen, Wei-Min(*). Synthesis, Molecular Docking, and Biofilm Formation Inhibitory Activity of 5-Substituted 3,4-Dihalo-5H-furan-2-one Derivatives on Pseudomonas aeruginosaChemical Biology & Drug Design2012795):628-638.

19.    Lan, PingWu, Zhi-WeiChen, Wan-NaSun, Ping-HuaChen, Wei-Min(*)Molecular modeling studies on phosphonic acid-containing thiazole derivatives: design for fructose-1,6-bisphosphatase inhibitorsJournal of Molecular Modeling2012183):973-990.

20.    Zhang, Dong-MeiShu, ChangChen, Jun-JiangSodani, KamleshWang, JiaoBhatnagar, JayaLan,PingRuan, Zhi-XiongXiao, Zhi-JieAmbudkar, Suresh V.Chen, Wei-MinChen, Zhe-ShengYe, Wen-Cai(*)BBA, a Derivative of 23-Hydroxybetulinic Acid, Potently Reverses ABCB1-Mediated Drug Resistance in Vitro and in VivoMolecular Pharmaceutics2012911):3147-3159.

21.    Zhao, Bing-XinWang, Ying(*)Zhang, Dong-MeiJiang, Ren-WangWang, Guo-CaiShi, Jun-MinHuang, Xiao-JunChen, Wei-MinChe, Chun-TaoYe, Wen-CaiFlueggines A and B, Two New Dimeric Indolizidine Alkaloids from Flueggea virosaOrganic Letters20111315):3888-3891.

22.    Song, Qiu-LingGuo, Bao-QinZhang, WenLan, PingSun, Ping-HuaChen, Wei-Min(*)Design, synthesis and antibacterial activity of novel ketolides bearing an aryltetrazolyl-substituted alkyl side chainJournal of Antibiotics2011648):571-581.

23.    Lan, Ping; Chen, Wan-Na; Huang, Zhi-Jian; Sun, Ping-Hua; Chen, Wei-Min(*). Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and dockingJournal of Molecular Modeling2011177):1643-1659.

24.    Lan, Ping; Sun, Jun-Rong; Chen, Wan-Na; Sun, Ping-Hua; Chen, Wei-Min(*). Molecular modelling studies on d-annulated benzazepinones as VEGF-R2 kinase inhibitors using docking and 3D-QSARJournal of Enzyme Inhibition and Medicinal Chemistry2011263):367-377.

25.    Lan, Ping; Wang, Jiao; Zhang, Dong-Mei; Shu, Chang; Cao, Hui-Hui; Sun, Ping-Hua; Wu, Xiao-Ming; Ye, Wen-Cai(*); Chen, Wei-Min(*). Synthesis and antiproliferative evaluation of 23-hydroxybetulinic acid derivativesEuropean Journal of Medicinal Chemistry2011466):2490-2502.

26.    Lan, Ping; Chen, Wan-Na; Chen, Wei-Min(*). Molecular modeling studies on imidazo[4,5-b]pyridine derivatives as Aurora A kinase inhibitors using 3D-QSAR and docking approachesEuropean Journal of Medicinal Chemistry2011461):77-94.

27.    Lan, Ping; Chen, Wan-Na; Sun, Ping-Hua; Chen, Wei-Min(*). 3D-QSAR and molecular docking studies of azaindole derivatives as Aurora B kinase inhibitorsJournal of Molecular Modeling2011175):1191-1205.

28.    Huang, Zhi-Jian; Zeng, Yi; Lan, Ping; Sun, Ping-Hua; Chen, Wei-Min(*). Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese MedicineMini-Reviews in Medicinal Chemistry20111113):1122-1129.

29.    Sun, Jun-Rong; Lan, Ping; Sun, Ping-Hua; Chen, Wei-Min(*). 3D-QSAR and Docking Studies on Pyrrolopyrimidine Derivatives as LIM-Kinase 2 InhibitorsLetters in Drug Design and Discovery201183):229-240.

30.    Lan, Ping; Xie, Mei-Qi; Yao, Yue-Mei; Chen, Wan-Na; Chen, Wei-Min(*). 3D-QSAR studies and molecular docking on [5-(4-amino-1H-benzoimidazol-2-yl)-furan-2-yl]-phosphonic acid derivatives as fructose-1,6-biphophatase inhibitorsJournal of Computer-Aided Molecular Design20102412):993-1008.

31.    Hu, Lei; Lan, Ping; Song, Qiu-Ling; Huang, Zhi-Jian; Sun, Ping-Hua; Zhuo, Chao; Wang, Ying; Xiao,Shunian; Chen, Wei-Min(*). Synthesis and antibacterial activity of C-12 pyrazolinyl spiro ketolidesEuropean Journal of Medicinal Chemistry20104512):5943-5949.

32.    Lan, Ping; Chen, Wan-Na; Xiao, Gao-Keng; Sun, Ping-Hua(*); Chen, Wei-Min(*). 3D-QSAR and docking studies on pyrazolo[4,3-h]qinazoline-3-carboxamides as cyclin-dependent kinase 2 (CDK2) inhibitorsBioorganic & Medicinal Chemistry Letters20102022):6764-6772.

*通讯作者

 

荣誉称号与奖励:

1.       叶文才,吴晓明,王广基,张冬梅,汪 豪,范春林,陈卫民,周芳,徐进宜,张晓琦,毕 毅,张经纬,孙建国,王英,赵守训。中药白头翁活性分成的系统研究与应用,广东省科技进步一等奖,2014

2.         陈卫民,余传林,徐继红,徐伟,刘叔文,金大地,吴曙光。新药依替膦酸二钠的研究,军队科技进步三等奖1998

3.         吴曙光,余传林,陈卫民,徐继红,刘叔文,徐伟,苗惠珠,付湘龙,陈望忠。抗高血压新药卡维地洛的研制及临床应用,军队科技进步二等奖1999

4.         吴曙光,陈卫民,余传林,徐继红,刘叔文。新型降血压药物的基础与临床研究,广东省科技进步三等奖1999

 

主要社会兼职:

1. 广东省药学会药物化学专业委员会 委员

2. European Journal of Medicinal Chemistry , Bioorganic & Medicinal Chemistry Letters, Chemical Biology & Drug Design,有机化学等国际国内学术期刊稿件评阅人。2015年被European Journal of Medicinal Chemistry授予Outstanding Reviewer; 2016Bioorganic & Medicinal Chemistry Letters授予Recognized Reviewer

 

联系方式:

Tel: 020-85224497

Email: twmchen@jnu.edu.cn